DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men and NAD-ME2

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_191966.2	Gene:	NAD-ME2 / 828222	AraportID:	AT4G00570	Length:	607	Species:	Arabidopsis thaliana

Alignment Length:	572	Identity:	221/572 - (38%)
Similarity:	335/572 - (58%)	Gaps:	39/572 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 LLDKRYSKGLAFTHEERQQLGIHGMLP----YVVREPSEQVEHCRALLARLDQD------LDKYM 276
            |.|..::|...|...||.:|||.|:||    ..|::....:|..|:|......:      |.|:.
plant    43 LHDPWFNKDTGFPLTERDRLGIRGLLPPRVMTCVQQCDRFIESFRSLENNTKGEPENVVALAKWR 107

  Fly   277 YLISLSERNERLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLK 341
            .|..|.:|||.|:|.||..:|....|::|||||||.||.||.:::..:||:.|.||||.:..::.
plant   108 MLNRLHDRNETLYYRVLIDNIKDFAPIIYTPTVGLVCQNYSGLYRRPRGMYFSAKDKGEMMSMIY 172

  Fly   342 NWPETDVRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESIL 406
            |||...|..||:|||.|||||||||..|:|||:|||.:|.|.|||.|.:.|||.||||||.|.:|
plant   173 NWPAPQVDMIVITDGSRILGLGDLGVQGIGIPIGKLDMYVAAAGINPQRVLPIMLDVGTNNEKLL 237

  Fly   407 EDPLYIGLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFND 471
            ::.||:|:|:.|..|:.|.|.|||||.|...|: ...::|||||....||..|.:||..||.|||
plant   238 QNDLYLGVRQPRLEGEEYLEIIDEFMEAAFTRW-PKAVVQFEDFQAKWAFGTLERYRKKFCMFND 301

  Fly   472 DIQGTASVAVAGLLASLKIKKTQLKD---NTLLFLGAGEAALGIANLCLMAM-KVEGLTEEEAKA 532
            |:||||.||:||||.:::.:...:.|   ..::.:|||.|.||:..:.:.|: ::.|::|.||..
plant   302 DVQGTAGVALAGLLGTVRAQGRPISDFVNQKIVVVGAGSAGLGVTKMAVQAVARMAGISESEATK 366

  Fly   533 RIWMVDSRGVITRDRPKGGLTEHKLHFAQLHEPID-----TLAEAVRKVRPNVLIGAAAQGGAFN 592
            ..:::|..|::|.:|.|  |....:.||:  .|.:     ::.|.|:||||:||:|.:..||.||
plant   367 NFYLIDKDGLVTTERTK--LDPGAVLFAK--NPAEIREGASIVEVVKKVRPHVLLGLSGVGGIFN 427

  Fly   593 QEILELMADINE-TPIIFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTYNNKKF-YPGQ 655
            :|:|:.|.:.:. .|.|||:||||..|||||.:|:.:..|..:|||||||..|...|.|. :..|
plant   428 EEVLKAMRESDSCKPAIFAMSNPTLNAECTAADAFKHAGGNIVFASGSPFENVELENGKVGHVNQ 492

  Fly   656 GNNSYIFPGVALGVLCAGMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAER 720
            .||.|:|||:.||.|.:|...:.:.:...|:|.||..::.:::.||.|||.:::|...:..:...
plant   493 ANNMYLFPGIGLGTLLSGARIVTDGMLQAASECLASYMTDEEVQKGILYPSINNIRHITAEVGAA 557

  Fly   721 IVEYAYKNGLA----TVRPEPVNKLA------FIKAQMYDLDYPRSVPATYK 762
            ::..|..:.:|    .|.|:.::.::      :|...|:   :|...|..::
plant   558 VLRAAVTDDIAEGHGDVGPKDLSHMSKEDTVNYITRNMW---FPVYSPLVHE 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	220/565 (39%)
		malic	282..463	CDD:278802	92/180 (51%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	99/297 (33%)
NAD-ME2	NP_191966.2	PLN03129	17..604	CDD:215594	221/568 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.690