DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Men and NADP-ME1

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_179580.1	Gene:	NADP-ME1 / 816509	AraportID:	AT2G19900	Length:	581	Species:	Arabidopsis thaliana

Alignment Length:	580	Identity:	284/580 - (48%)
Similarity:	383/580 - (66%)	Gaps:	13/580 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 TNLEDKMSKPDSKLDKYAQ-----RDRLGLWGTGDNEVVGSLSGFTRLLDKRYSKGLAFTHEERQ 239
            ||.:.|.|.....:|.|.:     ...:..|.      :...||::.|.|.||:||||||.:||.
plant     5 TNSDLKSSVDGGVVDVYGEDSATIEHNITPWS------LSVSSGYSLLRDPRYNKGLAFTEKERD 63

  Fly   240 QLGIHGMLPYVVREPSEQVEHCRALLARLDQDLDKYMYLISLSERNERLFYNVLSSDIAYMMPLV 304
            ...:.|:||.||.:...|.:.....:.:....|.|||.|..|.||||||||.:|..::..::|:|
plant    64 THYLRGLLPPVVLDQKLQEKRLLNNIRQYQFPLQKYMALTELQERNERLFYKLLIDNVEELLPIV 128

  Fly   305 YTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETDVRAIVVTDGERILGLGDLGANG 369
            ||||||.|||::..|.:..:|:|||:||||.|.||||||||.:::.||||||||||||||||..|
plant   129 YTPTVGEACQKFGSIFRRPQGLFISLKDKGKILDVLKNWPERNIQVIVVTDGERILGLGDLGCQG 193

  Fly   370 MGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYIGLRERRATGDLYDEFIDEFMHA 434
            ||||||||:||:||.|::||.|||:|:|||||.|.:|.|..|||||::||||..|.|.::|||.|
plant   194 MGIPVGKLALYSALGGVRPSACLPVTIDVGTNNEKLLNDEFYIGLRQKRATGQEYSELLNEFMSA 258

  Fly   435 CVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTASVAVAGLLASLKIKKTQLKDNT 499
            ..:.:|:..|||||||||.|||.||:||.|:...|||||||||||.:|||:::.|:..:.|.::|
plant   259 VKQNYGEKVLIQFEDFANHNAFELLAKYSDTHLVFNDDIQGTASVVLAGLVSAQKLTNSPLAEHT 323

  Fly   500 LLFLGAGEAALGIANLCLMAM-KVEGLTEEEAKARIWMVDSRGVITRDRPKGGLTEHKLHFAQLH 563
            .||||||||..|||.|..:.| |....:.||::.:||:|||:|:|...| |..|.:.|..:|..|
plant   324 FLFLGAGEAGTGIAELIALYMSKQMNASVEESRKKIWLVDSKGLIVNSR-KDSLQDFKKPWAHEH 387

  Fly   564 EPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPIIFALSNPTSKAECTAEEAYTY 628
            ||:..|..|::.::|.||||::..|.:|.:|::|.|:.|||.|:|.||||||:::|||||||||:
plant   388 EPVKDLLGAIKAIKPTVLIGSSGVGRSFTKEVIEAMSSINERPLIMALSNPTTQSECTAEEAYTW 452

  Fly   629 TKGRCIFASGSPFAPVTYNNKKFYPGQGNNSYIFPGVALGVLCAGMLNIPEQVFLVAAERLAELV 693
            :|||.||||||||.||.|..|.|...|.||:|||||..||::.:|.:.:.:.:.|.|||.||..|
plant   453 SKGRAIFASGSPFDPVEYEGKVFVSTQANNAYIFPGFGLGLVISGAIRVHDDMLLAAAEALAGQV 517

  Fly   694 SKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATVRPEPVNKLAFIKAQMYDLDY 753
            ||::..||.:||..|||...|..||..:...||:.|||...|.|.:.:...::.||...|
plant   518 SKENYEKGMIYPSFSSIRKISAQIAANVATKAYELGLAGRLPRPKDIVKCAESSMYSPTY 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	277/542 (51%)
		malic	282..463	CDD:278802	113/180 (63%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	130/277 (47%)
NADP-ME1	NP_179580.1	PLN03129	4..581	CDD:215594	284/580 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	263	1.000	Domainoid score	I469
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	559	1.000	Inparanoid score	I249
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm1109
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840