Protein Alignment Men and NAD-ME1

DIOPT Version :9

• Sequence 1: NP_524880.2
• Gene: Men / 47173
• FlyBaseID: FBgn0002719
• Length: 763
• Species: Drosophila melanogaster
• Sequence 2: NP_178980.1
• Gene: NAD-ME1 / 815842
• AraportID: AT2G13560
• Length: 623
• Species: Arabidopsis thaliana
• Alignment Length: 658
• Identity: 242/658 - (36%)
• Similarity: 364/658 - (55%)
• Gaps: 80/658 - (12%)

  Fly   142 LSLSSRHHWNQLQSSLHALHHQQQQQQQQLRSYSSTSETNLEDKMSKPDSKLDKYAQRDRLGLWG 206
            |.|||        |||..:.|::......:||: :|||
plant     7 LRLSS--------SSLSRILHRRILYSSAVRSF-TTSE--------------------------- 35

  Fly   207 TGDNEVVGSLSGFTRLLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARLDQD 271
             |....:....|...|.|..::||.|||..||.:|.:.|:||..|.:..:|:......|.||::.
plant    36 -GHRPTIVHKQGLDILHDPWFNKGTAFTMTERNRLDLRGLLPPNVMDSEQQIFRFMTDLKRLEEQ 99

  Fly   272 ----------LDKYMYLISLSERNERLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGM 326
                      |.|:..|..|.:|||.::|.||.::|....|:||||||||.||.||.:.:..:||
plant   100 ARDGPSDPNALAKWRILNRLHDRNETMYYKVLINNIEEYAPIVYTPTVGLVCQNYSGLFRRPRGM 164

  Fly   327 FISIKDKGHIYDVLKNWPETDVRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQC 391
            :.|.:|:|.:..::.|||...|..||||||.|||||||||.:|:||.||||.||.|.|||.|.:.
plant   165 YFSAEDRGEMMSMVYNWPAEQVDMIVVTDGSRILGLGDLGVHGIGIAVGKLDLYVAAAGINPQRV 229

  Fly   392 LPITLDVGTNTESILEDPLYIGLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAF 456
            ||:.:|||||.|.:..||:|:||::||...|.|.:.|||||.|...|: .:.::|||||.:..||
plant   230 LPVMIDVGTNNEKLRNDPMYLGLQQRRLEDDDYIDVIDEFMEAVYTRW-PHVIVQFEDFQSKWAF 293

  Fly   457 RLLSKYRDSFCTFNDDIQGTASVAVAGLLASLKIKKTQLKD---NTLLFLGAGEAALGIANLCLM 518
            :||.:||.::..||||:||||.||:||||.:::.:...:.|   ..::..|||.|.:|:.|....
plant   294 KLLQRYRCTYRMFNDDVQGTAGVAIAGLLGAVRAQGRPMIDFPKMKIVVAGAGSAGIGVLNAARK 358

  Fly   519 AM-KVEGLTE---EEAKARIWMVDSRGVITRDRPKGGLTEHKLHFAQLHEPID--------TLAE 571
            .| ::.|.||   :.|:::.|:||::|:||..|.  .:......||:..:.::        ||.|
plant   359 TMARMLGNTETAFDSAQSQFWVVDAQGLITEGRE--NIDPEAQPFARKTKEMERQGLKEGATLVE 421

  Fly   572 AVRKVRPNVLIGAAAQGGAFNQEILELMADINET-PIIFALSNPTSKAECTAEEAYTYTKGRCIF 635
            .||:|:|:||:|.:|.||.|::|:||.|.....| |.|||:||||..||||.::|::......||
plant   422 VVREVKPDVLLGLSAVGGLFSKEVLEAMKGSTSTRPAIFAMSNPTKNAECTPQDAFSILGENMIF 486

  Fly   636 ASGSPFAPVTYNNKKF-YPGQGNNSYIFPGVALGVLCAGMLNIPEQVFLVAAERLAELVSKDDLA 699
            ||||||..|.:.|... :..||||.|:|||:.||.|.:|...:.:.:...|:|.||..:|::::.
plant   487 ASGSPFKNVEFGNGHVGHCNQGNNMYLFPGIGLGTLLSGAPIVSDGMLQAASECLAAYMSEEEVL 551

  Fly   700 KGSLYPPLSSIVSCSMAIAERIVEYAYK----NGLATVRPEPVNKL------AFIKAQMYDLDYP 754
            :|.:|||:|.|...:..||..:::.|.:    .|...:....:.||      .:::..|::.:||
plant   552 EGIIYPPISRIRDITKRIAAAVIKEAIEEDLVEGYREMDAREIQKLDEEGLMEYVENNMWNPEYP 616

  Fly   755 RSVPATYK 762
            ..|   ||
plant   617 TLV---YK 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	225/580 (39%)
		malic	282..463	CDD:278802	91/180 (51%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	103/303 (34%)
NAD-ME1	NP_178980.1	PLN03129	25..619	CDD:215594	231/625 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.690