DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Men and me3

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_001082825.1	Gene:	me3 / 492719	ZFINID:	ZDB-GENE-041111-294	Length:	603	Species:	Danio rerio

Alignment Length:	537	Identity:	309/537 - (57%)
Similarity:	394/537 - (73%)	Gaps:	3/537 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 GFTRLLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARLDQDLDKYMYLISLS 282
            |:....:...:||:|||.|||.||||||:||........||.............||||:.|::|.
Zfish    49 GYDITRNPHLNKGMAFTLEERLQLGIHGLLPPCFLSQDVQVLRVMKSYETRSNPLDKYILLMTLQ 113

  Fly   283 ERNERLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETD 347
            :|||:|||.||:|||...||:|||||||||||:|.|..:..:|:||:|.|||||..:|.:|||.|
Zfish   114 DRNEKLFYRVLTSDIEEFMPIVYTPTVGLACQQYGLAFRRPRGLFITIHDKGHIATMLNSWPEED 178

  Fly   348 VRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYI 412
            ::|||||||||||||||||..|||||||||:||||..|:.|.||||:.|||||:.:::|:|||||
Zfish   179 IKAIVVTDGERILGLGDLGGYGMGIPVGKLALYTACGGVPPQQCLPVLLDVGTDNQTLLDDPLYI 243

  Fly   413 GLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTA 477
            ||:.:|..|..||:.|||||.|...::|.|||||||||||:||||:|:|||:.:|||||||||||
Zfish   244 GLKHKRVRGKEYDDLIDEFMQAVTDKYGMNCLIQFEDFANSNAFRILNKYRNRYCTFNDDIQGTA 308

  Fly   478 SVAVAGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMVDSRGV 542
            ||||||:||:|||.|.:|.|:..:|.||||||||||:|.:|||..||:...||..|||||||:|:
Zfish   309 SVAVAGILAALKITKNKLSDHKFVFQGAGEAALGIAHLLIMAMAKEGIPHAEAAQRIWMVDSKGL 373

  Fly   543 ITRDRPKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPI 607
            |.:.|  ..|...|..||..|..|.||.|.|..::|..:||.||.||||.::|::.||..||.||
Zfish   374 IVKGR--SHLNHEKEEFAHDHPHIKTLEEVVETIKPTAIIGVAAIGGAFTEKIIKNMAANNERPI 436

  Fly   608 IFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTY-NNKKFYPGQGNNSYIFPGVALGVLC 671
            ||||||||||||||||:.||.|:||.||||||||..||. :.:.||||||||:|:||||||||:.
Zfish   437 IFALSNPTSKAECTAEQCYTLTEGRGIFASGSPFKKVTLADGRSFYPGQGNNAYVFPGVALGVIA 501

  Fly   672 AGMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATVRPE 736
            .|:.:|.:.:||..||.::|:|:::.||:|.|||||.:|...|..||.:||::|||.|:|:..||
Zfish   502 CGVRHISDDIFLTTAEAISEMVTEEHLAEGRLYPPLKTIREVSFKIAVKIVDHAYKQGIASWYPE 566

  Fly   737 PVNKLAFIKAQMYDLDY 753
            |.:|.|||.:.:|:.||
Zfish   567 PKDKEAFILSHVYNSDY 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	309/537 (58%)
		malic	282..463	CDD:278802	117/180 (65%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	156/277 (56%)
me3	NP_001082825.1	PLN03129	47..587	CDD:215594	309/537 (58%)
		malic	113..294	CDD:278802	117/180 (65%)
		NAD_bind_1_malic_enz	304..580	CDD:133454	156/277 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595263
Domainoid	1	1.000	292	1.000	Domainoid score	I1493
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm6390
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2182
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.750