DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men and me2

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_001003627.2	Gene:	me2 / 445233	ZFINID:	ZDB-GENE-040801-147	Length:	581	Species:	Danio rerio

Alignment Length:	544	Identity:	285/544 - (52%)
Similarity:	393/544 - (72%)	Gaps:	7/544 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 LLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARLDQDLDKYMYLISLSERNE 286
            :|:.|.:||:|||.:|||.|||||:||..:.....|....:..|.::...|.||:||:.:.||||
Zfish    29 MLNPRTNKGMAFTLKERQMLGIHGLLPSKIETQDTQAMRFQKNLKKMSDPLQKYIYLMGIQERNE 93

  Fly   287 RLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETDVRAI 351
            ||||.||..||..:||:||||||||||.:|..|.:..||:||||||:|||..:|.|||:|.|:|:
Zfish    94 RLFYRVLMEDIEALMPIVYTPTVGLACTQYGHIFRRPKGLFISIKDQGHIRSILDNWPDTSVKAV 158

  Fly   352 VVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYIGLRE 416
            |||||||||||||||..|||||||||.||||.|||:|..|||:.:||||:.|.:|.||.|:||.:
Zfish   159 VVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPESCLPVCIDVGTDNEKLLRDPFYMGLYQ 223

  Fly   417 RRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTASVAV 481
            ||.....||:.|||||.|.|.::||:.|||||||.|.||||.|.|||:.:||||||||||||||:
Zfish   224 RRDRSQRYDDLIDEFMEAVVDKYGQDTLIQFEDFGNHNAFRFLKKYREKYCTFNDDIQGTASVAL 288

  Fly   482 AGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMVDSRGVITRD 546
            |||||:.:.....|.::.:|||||||||||||||.:|||...|:::.:|:.:|||.|..|::.:|
Zfish   289 AGLLAAQRAVGKPLTEHKVLFLGAGEAALGIANLIVMAMMESGMSQADARKKIWMFDKYGLLVKD 353

  Fly   547 RPKGGLTEHKLHFAQLH-EP--IDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPII 608
            |.....:..:   |.:| :|  :.:..:||..::|..:||.:..|..|..::::.|.::||.|||
Zfish   354 RAYETDSNQE---AFVHPDPGDVKSFLDAVNVIKPTAIIGVSGAGRLFTHDVIKAMGNLNERPII 415

  Fly   609 FALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTYNNKKFY-PGQGNNSYIFPGVALGVLCA 672
            |||||||:|||||||:||:.|:|||:||||||||||:..:.:.. ||||||:||||||||.|:.:
Zfish   416 FALSNPTAKAECTAEDAYSLTQGRCLFASGSPFAPVSLEDGRILTPGQGNNAYIFPGVALAVILS 480

  Fly   673 GMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATVRPEP 737
            |:.:|.:.|||.||:.||:.::.::|::|.||||||:|...|:.:|.::|||.|..|:|...|||
Zfish   481 GVRHISDTVFLEAAKTLADQLTDEELSQGRLYPPLSNIREVSLQMAIKVVEYVYSKGMAFRYPEP 545

  Fly   738 VNKLAFIKAQMYDLDYPRSVPATY 761
            |:|.:::::.:::.:|...:|..|
Zfish   546 VDKESYVRSVVWNTNYDSFLPDIY 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	283/538 (53%)
		malic	282..463	CDD:278802	117/180 (65%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	133/280 (48%)
me2	NP_001003627.2	PLN03129	18..565	CDD:215594	283/538 (53%)
		malic	89..270	CDD:278802	117/180 (65%)
		NAD_bind_1_malic_enz	280..559	CDD:133454	133/281 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595268
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm6390
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2182
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790