DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Men and ME2

DIOPT Version :9

Sequence 1:NP_524880.2 Gene:Men / 47173 FlyBaseID:FBgn0002719 Length:763 Species:Drosophila melanogaster
Sequence 2:NP_002387.1 Gene:ME2 / 4200 HGNCID:6984 Length:584 Species:Homo sapiens


Alignment Length:556 Identity:280/556 - (50%)
Similarity:381/556 - (68%) Gaps:28/556 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   222 LLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRAL-----LARLDQDLDKYMYLISL 281
            :|:.|.:||:|||.:|||.||:.|:||     |..:.:..:||     |.::...|:||:|::.:
Human    29 MLNPRTNKGMAFTLQERQMLGLQGLLP-----PKIETQDIQALRFHRNLKKMTSPLEKYIYIMGI 88

  Fly   282 SERNERLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPET 346
            .||||:|||.:|..||..:||:||||||||||.:|..|.:..||:||||.|:||:..::.||||.
Human    89 QERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPEN 153

  Fly   347 DVRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLY 411
            .|:|:|||||||||||||||..|||||||||.||||.|||:|.:|||:.:||||:..::|:||.|
Human   154 HVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFY 218

  Fly   412 IGLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGT 476
            :||.::|.....||:.|||||.|...|:|:|.|||||||.|.||||.|.|||:.:||||||||||
Human   219 MGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGT 283

  Fly   477 ASVAVAGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMVDSRG 541
            |:||:|||||:.|:....:.::.:|||||||||||||||.:|:|...||:|:||:.:|||.|..|
Human   284 AAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYG 348

  Fly   542 VITRDRPKGGLTEHKLHFAQLHEPI---------DTLAEAVRKVRPNVLIGAAAQGGAFNQEILE 597
            ::.:.|        |.......||.         ||..:||..::|:.:||.|..|..|..:::.
Human   349 LLVKGR--------KAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIR 405

  Fly   598 LMADINETPIIFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTY-NNKKFYPGQGNNSYI 661
            .||.|||.|:||||||||::||||||||||.|:|||:|||||||.||.. :.:.|.||||||.||
Human   406 AMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYI 470

  Fly   662 FPGVALGVLCAGMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAY 726
            ||||||.|:.....:|.:.|||.||:.|...::.::||:|.|||||::|...|:.||.::.||.|
Human   471 FPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLY 535

  Fly   727 KNGLATVRPEPVNKLAFIKAQMYDLDYPRSVPATYK 762
            .|.:|...|||.:|..::|.:.:..:|...:|..|:
Human   536 ANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYE 571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MenNP_524880.2 PLN03129 213..757 CDD:215594 278/549 (51%)
malic 282..463 CDD:278802 110/180 (61%)
NAD_bind_1_malic_enz 473..750 CDD:133454 136/286 (48%)
ME2NP_002387.1 PLN03129 28..566 CDD:215594 278/549 (51%)
malic 89..270 CDD:278802 110/180 (61%)
NAD_bind_1_malic_enz 280..558 CDD:133454 136/285 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159164
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0281
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG60768
OrthoDB 1 1.010 - - D334471at33208
OrthoFinder 1 1.000 - - FOG0000475
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100205
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2182
SonicParanoid 1 1.000 - - X340
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.650

Return to query results.
Submit another query.