DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men and ME1

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_002386.1	Gene:	ME1 / 4199	HGNCID:	6983	Length:	572	Species:	Homo sapiens

Alignment Length:	550	Identity:	321/550 - (58%)
Similarity:	408/550 - (74%)	Gaps:	13/550 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 GFTRLLDKRYSKGLAFTHEERQQLGIHGMLPYVVREP---SEQVEHCRAL--LARLDQDLDKYMY 277
            |:....:...:|.||||.||||||.|||:||     |   |::::..|.:  ...|:.|.|:|:.
Human    15 GYLLTRNPHLNKDLAFTLEERQQLNIHGLLP-----PSFNSQEIQVLRVVKNFEHLNSDFDRYLL 74

  Fly   278 LISLSERNERLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKN 342
            |:.|.:|||:|||.||:|||...||:|||||||||||:|||:.:..:|:||:|.|:|||..||..
Human    75 LMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNA 139

  Fly   343 WPETDVRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILE 407
            |||..::|||||||||||||||||.||||||||||:||||..|:.|.:|||:.|||||..|.:|:
Human   140 WPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLK 204

  Fly   408 DPLYIGLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDD 472
            ||||||||:||..|..||:|:||||.|...::|.|||||||||||.||||||:|||:.:||||||
Human   205 DPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDD 269

  Fly   473 IQGTASVAVAGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMV 537
            ||||||||||||||:|:|.|.:|.|.|:||.||||||||||:|.:||::.|||.:|:|..:||:|
Human   270 IQGTASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLV 334

  Fly   538 DSRGVITRDRPKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADI 602
            ||:|:|.:.|  ..||:.|..||..||.:..|...|::::|..|||.||.||||:::||:.||..
Human   335 DSKGLIVKGR--ASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAF 397

  Fly   603 NETPIIFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTY-NNKKFYPGQGNNSYIFPGVA 666
            ||.|||||||||||||||:||:.|..||||.||||||||.|||. |.:..|||||||||:|||||
Human   398 NERPIIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVA 462

  Fly   667 LGVLCAGMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLA 731
            |||:..|:..|.:.:||..||.:|:.||...|.:|.|||||::|...|:.|||:||:.||:...|
Human   463 LGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTA 527

  Fly   732 TVRPEPVNKLAFIKAQMYDLDYPRSVPATY 761
            ||.|||.||.||:::|||..||.:.:|..|
Human   528 TVYPEPQNKEAFVRSQMYSTDYDQILPDCY 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	319/544 (59%)
		malic	282..463	CDD:278802	121/180 (67%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	161/277 (58%)
ME1	NP_002386.1	PLN03129	11..551	CDD:215594	319/542 (59%)
		malic	79..260	CDD:278802	121/180 (67%)
		NAD_bind_1_malic_enz	270..547	CDD:133454	162/278 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159169
Domainoid	1	1.000	284	1.000	Domainoid score	I1639
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134785
Inparanoid	1	1.050	635	1.000	Inparanoid score	I831
Isobase	1	0.950	-	0	Normalized mean entropy	S996
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm8644
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2182
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750