DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Men and CG7848

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_611127.1	Gene:	CG7848 / 36839	FlyBaseID:	FBgn0034127	Length:	633	Species:	Drosophila melanogaster

Alignment Length:	606	Identity:	236/606 - (38%)
Similarity:	350/606 - (57%)	Gaps:	23/606 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 QQQQQQQQLRSYSSTSETNLEDKMSKPDSKLDKYAQRDRLGLWGTGDNEVVGS-LSGFTRLLDKR 226
            ::.|:.::|:..|:..:|.:.|.|.:   .:|.:        |.. |..:.|| :.|...|....
  Fly    28 EELQKNKELKCVSNYDKTEILDYMPR---YMDTF--------WKM-DTRLSGSKVDGLWMLNQSN 80

  Fly   227 YSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARLDQDLDKYMYLISLSERNERLFYN 291
            |:||||||..||:.|.|||:||..||...||.|.|..||.....::.:|:||..||.||.||||.
  Fly    81 YNKGLAFTLNERRVLSIHGLLPVAVRTIDEQAEICSNLLESFTNNVQQYIYLTYLSRRNRRLFYY 145

  Fly   292 VLSSDIAYMMPLVYTPTVG----LACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETDVRAIV 352
            :|.|:....:|:  |...|    |...|  :||...:|::|.|||.||:..:|.|||...||.::
  Fly   146 LLLSNPDRFVPM--TDASGSIDLLMVHR--MIHSMGQGLYICIKDLGHVSQILSNWPFRCVRCLL 206

  Fly   353 VTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYIGLRER 417
            |::|..:|.:||||.:.|.|....|.......||.|:.||.:.||||||.|.:|.||:|.|||||
  Fly   207 VSNGASVLSVGDLGVDEMPILFSNLHQNVVYGGIHPAYCLAVMLDVGTNNEELLNDPMYTGLRER 271

  Fly   418 RATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTASVAVA 482
            |.:..|||:..:||..:.::::|...||..:||....|.:.|..||:..|..:.|.|..|:||:|
  Fly   272 RCSEKLYDQLFEEFTLSVMQQYGPRALILCKDFEAQKAKKQLELYRERQCIVDVDFQCFAAVALA 336

  Fly   483 GLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMVDSRGVITRDR 547
            |::...::|:.....|..||.||....:|:|.||::.:|.|||.|.:|:.:||..|:.|::...|
  Fly   337 GVIVCNRLKRVFFSSNVFLFYGAEAINIGMARLCMVLLKREGLIEMKAREKIWFFDANGLVVLGR 401

  Fly   548 PKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPIIFALS 612
            .  .:.|..|.||...:||..|.||:::::||:|:|.::....|..::|..|....:.|:|||||
  Fly   402 K--DIPEELLEFANQRDPILDLVEAIQELKPNILVGGSSLPNTFTPDVLRAMEKSADQPVIFALS 464

  Fly   613 NPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTYNNKKFYPGQGNNSYIFPGVALGVLCAGMLNI 677
            .|..:.||:||:|::||||.|||.|||...|:.|.||.:.||...:||:..|::.||:.||..||
  Fly   465 RPLEQTECSAEDAFSYTKGHCIFISGSKLPPLKYANKWYQPGHCTSSYLVAGISCGVMLAGFTNI 529

  Fly   678 PEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATVRPEPVNKLA 742
            |::.|.|||||||.||...||.|.::|||:..|...|:.|||.|..||:..||||:.|:|.|.:.
  Fly   530 PDEAFCVAAERLASLVWPCDLEKRNVYPPMRKIQCISLQIAEAIFSYAFGRGLATLYPQPENPME 594

  Fly   743 FIKAQMYDLDYPRSVPATYKM 763
            :||..||:.:|..::...|.|
  Fly   595 YIKNSMYNPEYRMNIVDVYCM 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	225/548 (41%)
		malic	282..463	CDD:278802	73/184 (40%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	115/276 (42%)
CG7848	NP_611127.1	PLN03129	81..606	CDD:215594	220/530 (42%)
		malic	138..317	CDD:278802	72/182 (40%)
		NAD_bind_1_malic_enz	327..603	CDD:133454	116/277 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469222
Domainoid	1	1.000	155	1.000	Domainoid score	I893
eggNOG	1	0.900	-	-		E1_COG0281
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I521
Isobase	1	0.950	-	0	Normalized mean entropy	S996
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
	10	9.850