DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men and Me3

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_001101961.2	Gene:	Me3 / 361602	RGDID:	1311070	Length:	605	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	292/557 - (52%)
Similarity:	386/557 - (69%)	Gaps:	26/557 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 GFTRLLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARLDQDLDKYMYLISLS 282
            |:....:...:||:|||.|||.||||||::|........|:............|||||:.|::|.
  Rat    50 GYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYENQQSDLDKYIILMTLQ 114

  Fly   283 ERNERLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETD 347
            :|||:|||.||:||:...||:|||||||||||.|.|..:..:|:||:|.|||||..:|.:|||.:
  Rat   115 DRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHIATMLNSWPEDN 179

  Fly   348 VRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYI 412
            ::|:|||||||||||||||..|||||||||:||||..|:.|.||||:.||||||.|.:|.|||||
  Rat   180 IKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYI 244

  Fly   413 GLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTA 477
            ||:.:|..|..||:.:||||.|...:||.||||||||||||||||||:|||:.:|.|||||||||
  Rat   245 GLKHQRVRGKEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTA 309

  Fly   478 SVAVAGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMVDSRGV 542
            ||||||:||:|:|.|.:|.::..:|.||||||:|||:|.:||::.||:.:.||..:||||||:|:
  Rat   310 SVAVAGILAALRITKNRLSNHVFVFQGAGEAAMGIAHLLVMALEKEGIPKTEAVRKIWMVDSKGL 374

  Fly   543 ITRDRPKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPI 607
            |.:.|  ..|...|..|||.|..:::|.|.||.|:|..:||.||..|||.::||..||..:|.||
  Rat   375 IVKGR--SHLNHEKEMFAQEHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPI 437

  Fly   608 IFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTY-NNKKFYPGQGNNSYIFPGVALGVLC 671
            ||||||||||||||||:.|..|:||.||||||||..||. :.:.|.||||||:|:|||||||::.
  Rat   438 IFALSNPTSKAECTAEKCYQVTEGRGIFASGSPFKSVTLEDGRTFIPGQGNNAYVFPGVALGIIA 502

  Fly   672 AGMLNIPEQVFLVAAE------------RLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEY 724
            .|:.::|:::||:.||            |:.|:..    .:.::.|.::|       ...::::|
  Rat   503 GGIRHVPDEIFLLTAEVAAWNIKHVEETRIQEVRG----TESAVQPAVAS-------QRTKVLDY 556

  Fly   725 AYKNGLATVRPEPVNKLAFIKAQMYDLDYPRSVPATY 761
            |||:.||:..|||.:|.||||:.:|..||......||
  Rat   557 AYKHNLASYYPEPKDKEAFIKSLIYTPDYDSFSLDTY 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	290/551 (53%)
		malic	282..463	CDD:278802	118/180 (66%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	138/289 (48%)
Me3	NP_001101961.2	PLN03129	9..588	CDD:215594	290/550 (53%)
		malic	114..295	CDD:278802	118/180 (66%)
		NAD_bind_1_malic_enz	305..583	CDD:133454	139/290 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353182
Domainoid	1	1.000	281	1.000	Domainoid score	I1599
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	639	1.000	Inparanoid score	I790
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm9123
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770