DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men and Me2

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	XP_006254985.1	Gene:	Me2 / 307270	RGDID:	1310321	Length:	591	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	278/548 - (50%)
Similarity:	383/548 - (69%)	Gaps:	14/548 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 LLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRAL-----LARLDQDLDKYMYLISL 281
            :|:.|.:||:|||.:|||.||:.|:||     |..:.:..:||     |.::...|:||:|::.:
  Rat    36 MLNPRTNKGMAFTLQERQMLGLQGLLP-----PKIETQDIQALRFHRNLKKMTSPLEKYIYIMGI 95

  Fly   282 SERNERLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPET 346
            .||||:|||.:|..||..:||:||||||||||.:|..|.:..||:||||.|:||:..::.||||.
  Rat    96 QERNEKLFYRILQDDIESLMPIVYTPTVGLACCQYGHIFRRPKGLFISISDRGHVRSIVDNWPEN 160

  Fly   347 DVRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLY 411
            .|:|:|||||||||||||||..|||||||||.||||.|||:|.:|||:.:||||:..::|:||.|
  Rat   161 HVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIQPEKCLPVCIDVGTDNMALLKDPFY 225

  Fly   412 IGLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGT 476
            :||.::|....|||:.:||||.|...|:|:|.|||||||.|.||||.|.||::.:||||||||||
  Rat   226 MGLYQKRDRSQLYDDLMDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLKKYQEKYCTFNDDIQGT 290

  Fly   477 ASVAVAGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMVDSRG 541
            |:||::||||:.::....:.::.:|||||||||||||.|.:::|...||:||||:.:|||.|..|
  Rat   291 AAVALSGLLAAQRVINKPISEHRILFLGAGEAALGIAKLIVISMMESGLSEEEAQRKIWMFDKNG 355

  Fly   542 VITRDRPK--GGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINE 604
            ::.:.|..  ....|...|.|..:.|. |..:||.|::|:|:||.|..|..|...:::.||.|||
  Rat   356 LLVKGRTARIDSNQEPYAHAASENIPA-TFEDAVNKLKPSVIIGVAGAGPLFTPGVIKAMAAINE 419

  Fly   605 TPIIFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPV-TYNNKKFYPGQGNNSYIFPGVALG 668
            .||||||||||::||||||:|||.|:|||:|||||||.|| ..:.:.|.||||||:||||||||.
  Rat   420 RPIIFALSNPTAQAECTAEDAYTLTEGRCLFASGSPFEPVRLQDGRVFTPGQGNNAYIFPGVALA 484

  Fly   669 VLCAGMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATV 733
            |:.....:|.:.|||.||:.|...::.::||:|.|||.|::|...|..||.:|.||.|.|.:|..
  Rat   485 VILCEARHISDTVFLEAAKALTSQLTDEELAQGRLYPSLANIQEVSANIAIKIAEYLYANKMAFR 549

  Fly   734 RPEPVNKLAFIKAQMYDLDYPRSVPATY 761
            .|||.:|..::|.:::..:|...:|..|
  Rat   550 YPEPEDKAKYVKERIWRSNYVSLLPDVY 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	276/542 (51%)
		malic	282..463	CDD:278802	110/180 (61%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	135/279 (48%)
Me2	XP_006254985.1	PLN03129	35..573	CDD:215594	276/542 (51%)
		malic	96..277	CDD:278802	110/180 (61%)
		NAD_bind_1_malic_enz	287..565	CDD:133454	135/278 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm9123
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.620