DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men and mae2

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_587760.1	Gene:	mae2 / 2539592	PomBaseID:	SPCC794.12c	Length:	565	Species:	Schizosaccharomyces pombe

Alignment Length:	538	Identity:	191/538 - (35%)
Similarity:	293/538 - (54%)	Gaps:	31/538 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 LSGFTRLLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARL-DQDLDKYMYLI 279
            |.|.|.|...||:|..|||.||||:..|...||.:|....:||:.|......: |:.|.|.:||.
pombe    13 LKGVTLLNSPRYNKDTAFTPEERQKFEISSRLPPIVETLQQQVDRCYDQYKAIGDEPLQKNLYLS 77

  Fly   280 SLSERNERLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISI--KDKGHIYDVLKN 342
            .||..|:.|||.::|..:..|:|::||||.|.|.:::|.|::..:|.::.|  .|..:|...|..
pombe    78 QLSVTNQTLFYALISQHLIEMIPIIYTPTEGDAIKQFSDIYRYPEGCYLDIDHNDLSYIKQQLSE 142

  Fly   343 WPETD-VRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESIL 406
            :.::| |..|::||.|.|||:||.|..|:.|.|.|..|.|..||:.|::.|||.||||||.|:..
pombe   143 FGKSDSVEYIIITDSEGILGIGDQGVGGVLISVAKGHLMTLCAGLDPNRFLPIVLDVGTNNETHR 207

  Fly   407 EDPLYIGLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFND 471
            ::..|:|||:.|..|:.||.|:|..:.| :|.......|.||||..|||.|:|..||.....|||
pombe   208 KNHQYMGLRKDRVRGEQYDSFLDNVIKA-IREVFPEAFIHFEDFGLANAKRILDHYRPDIACFND 271

  Fly   472 DIQGTASVAVAGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWM 536
            |||||.:||:|.::.:|.:.|:.|.:..::..|||.|.:||||..:..|..:||:.::|:..::|
pombe   272 DIQGTGAVALAAIIGALHVTKSPLTEQRIMIFGAGTAGVGIANQIVAGMVTDGLSLDKARGNLFM 336

  Fly   537 VDSRGV-------ITRDRPKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQE 594
            :|..|:       |..|..|..|.:.. .|.::......|..|:..|:|.:|:|.:.|.|.|.::
pombe   337 IDRCGLLLERHAKIATDGQKPFLKKDS-DFKEVPSGDINLESAIALVKPTILLGCSGQPGKFTEK 400

  Fly   595 ILELMADINETPIIFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTYNNKKFYPGQGNNS 659
            .:..|:...|.||||.:||||:..|...::...::.|:.:.|:|||..|:..|.||:...|.||:
pombe   401 AIREMSKHVERPIIFPISNPTTLMEAKPDQIDKWSDGKALIATGSPLPPLNRNGKKYVISQCNNA 465

  Fly   660 YIFPGVALGVLCA---------GMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSM 715
            .::|  ||||.|.         |||.       .|::.||.:......|..:|.|.|::....|.
pombe   466 LLYP--ALGVACVLSRCKLLSDGMLK-------AASDALATVPRSLFAADEALLPDLNNAREISR 521

  Fly   716 AIAERIVEYAYKNGLATV 733
            .|...:::.|...|::||
pombe   522 HIVFAVLKQAVSEGMSTV 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	191/538 (36%)
		malic	282..463	CDD:278802	74/183 (40%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	84/277 (30%)
mae2	NP_587760.1	PRK13529	1..565	CDD:237414	191/538 (36%)
		malic	82..263	CDD:278802	73/181 (40%)
		NAD_bind_1_malic_enz	273..559	CDD:133454	84/277 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	147	1.000	Domainoid score	I1122
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I521
OMA	1	1.010	-	-		QHG60768
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm9297
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2182
SonicParanoid	1	1.000	-	-		X340
TreeFam	1	0.960	-	-
	11	10.760