DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men and Me1

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_036732.3	Gene:	Me1 / 24552	RGDID:	3074	Length:	572	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	326/545 - (59%)
Similarity:	402/545 - (73%)	Gaps:	3/545 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 GFTRLLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARLDQDLDKYMYLISLS 282
            |:....|...:|.||||.||||||.|||:||..:.....||........||:.|.|:|:.|:.|.
  Rat    15 GYLLTRDPHLNKDLAFTLEERQQLNIHGLLPPCIVNQEIQVLRVIKNFERLNSDFDRYLLLMDLQ 79

  Fly   283 ERNERLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETD 347
            :|||:|||:||.|::...||:|||||||||||:|||..:..:|:||||.|||||..||..|||..
  Rat    80 DRNEKLFYSVLMSNVEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDKGHIASVLNAWPEDV 144

  Fly   348 VRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYI 412
            |:|||||||||||||||||.||||||||||:||||..|:.|.|||||||||||..|.:|:|||||
  Rat   145 VKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQQCLPITLDVGTENEELLKDPLYI 209

  Fly   413 GLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTA 477
            |||.||..|..||.|:||||.|...::|.|||||||||||.||||||:|||:.:|||||||||||
  Rat   210 GLRHRRVRGPEYDAFLDEFMEAASSKYGMNCLIQFEDFANLNAFRLLNKYRNKYCTFNDDIQGTA 274

  Fly   478 SVAVAGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMVDSRGV 542
            |||||||||:|:|.|.:|.|.|:||.||||||||||:|.:|||:.|||::|:|:.:||:|||:|:
  Rat   275 SVAVAGLLAALRITKNKLSDQTVLFQGAGEAALGIAHLIVMAMEKEGLSKEKARQKIWLVDSKGL 339

  Fly   543 ITRDRPKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPI 607
            |.:.|  ..|||.|..||..||.:..|...|:|::|..|||.||.||||.::||:.||..||.||
  Rat   340 IVKGR--ASLTEEKEVFAHEHEEMKNLEAIVQKIKPTALIGVAAIGGAFTEQILKDMAAFNERPI 402

  Fly   608 IFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTY-NNKKFYPGQGNNSYIFPGVALGVLC 671
            |||||||||||||:|||.|..||||.||||||||.|||. :.:..:||||||||:||||||||:.
  Rat   403 IFALSNPTSKAECSAEECYKVTKGRAIFASGSPFDPVTLPDGRTLFPGQGNNSYVFPGVALGVVA 467

  Fly   672 AGMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATVRPE 736
            .|:.:|.:.|||..||.:::.||...|.:|.|||||::|...|:.||.:||:.|||..:|||.||
  Rat   468 CGLRHINDSVFLTTAEVISQQVSDKHLEEGRLYPPLNTIRDVSLKIAVKIVQDAYKEKMATVYPE 532

  Fly   737 PVNKLAFIKAQMYDLDYPRSVPATY 761
            |.||..|:.:|||..:|.:.:|..|
  Rat   533 PQNKEEFVSSQMYSTNYDQILPDCY 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	324/539 (60%)
		malic	282..463	CDD:278802	125/180 (69%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	162/277 (58%)
Me1	NP_036732.3	PLN03129	11..551	CDD:215594	324/537 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353177
Domainoid	1	1.000	281	1.000	Domainoid score	I1599
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134785
Inparanoid	1	1.050	639	1.000	Inparanoid score	I790
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm9123
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770