DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men and Me1

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_032641.2	Gene:	Me1 / 17436	MGIID:	97043	Length:	572	Species:	Mus musculus

Alignment Length:	545	Identity:	326/545 - (59%)
Similarity:	402/545 - (73%)	Gaps:	3/545 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 GFTRLLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARLDQDLDKYMYLISLS 282
            |:....|...:|.||||.||||||.|||:||..:.....||........||:.|.|:|:.|:.|.
Mouse    15 GYLLTRDPHLNKDLAFTLEERQQLNIHGLLPPCIISQELQVLRIIKNFERLNSDFDRYLLLMDLQ 79

  Fly   283 ERNERLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETD 347
            :|||:|||:||.||:...||:|||||||||||:|||..:..:|:||||.|||||..||..|||..
Mouse    80 DRNEKLFYSVLMSDVEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDKGHIASVLNAWPEDV 144

  Fly   348 VRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYI 412
            |:|||||||||||||||||.||||||||||:||||..|:.|.|||||||||||..|.:|:|||||
Mouse   145 VKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQQCLPITLDVGTENEELLKDPLYI 209

  Fly   413 GLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTA 477
            |||.||..|..||.|:||||.|...::|.|||||||||||.||||||:|||:.:|||||||||||
Mouse   210 GLRHRRVRGPEYDAFLDEFMEAASSKYGMNCLIQFEDFANRNAFRLLNKYRNKYCTFNDDIQGTA 274

  Fly   478 SVAVAGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMVDSRGV 542
            |||||||||:|:|.|.:|.|.|:||.||||||||||:|.:|||:.|||::|.|:.:||:|||:|:
Mouse   275 SVAVAGLLAALRITKNKLSDQTVLFQGAGEAALGIAHLVVMAMEKEGLSKENARKKIWLVDSKGL 339

  Fly   543 ITRDRPKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPI 607
            |.:.|  ..|||.|..||..||.:..|...|:|::|..|||.||.||||.::||:.||..||.||
Mouse   340 IVKGR--ASLTEEKEVFAHEHEEMKNLEAIVQKIKPTALIGVAAIGGAFTEQILKDMAAFNERPI 402

  Fly   608 IFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTY-NNKKFYPGQGNNSYIFPGVALGVLC 671
            |||||||||||||:||:.|..||||.||||||||.|||. :.:..:||||||||:||||||||:.
Mouse   403 IFALSNPTSKAECSAEQCYKVTKGRAIFASGSPFDPVTLPDGRTLFPGQGNNSYVFPGVALGVVA 467

  Fly   672 AGMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATVRPE 736
            .|:.:|.::|||..||.:::.||...|.:|.|||||::|...|:.||.:||:.|||..:|||.||
Mouse   468 CGLRHIDDKVFLTTAEVISQQVSDKHLQEGRLYPPLNTIRGVSLKIAVKIVQDAYKEKMATVYPE 532

  Fly   737 PVNKLAFIKAQMYDLDYPRSVPATY 761
            |.||..|:.:|||..:|.:.:|..|
Mouse   533 PQNKEEFVSSQMYSTNYDQILPDCY 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	324/539 (60%)
		malic	282..463	CDD:278802	126/180 (70%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	161/277 (58%)
Me1	NP_032641.2	PLN03129	2..551	CDD:215594	324/537 (60%)
		malic	79..260	CDD:278802	126/180 (70%)
		NAD_bind_1_malic_enz	270..547	CDD:133454	162/278 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849539
Domainoid	1	1.000	280	1.000	Domainoid score	I1669
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134785
Inparanoid	1	1.050	640	1.000	Inparanoid score	I813
Isobase	1	0.950	-	0	Normalized mean entropy	S996
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm8876
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2182
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750