DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men and ME3

DIOPT Version :9

Sequence 1:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_001014811.1	Gene:	ME3 / 10873	HGNCID:	6985	Length:	604	Species:	Homo sapiens

Alignment Length:	537	Identity:	302/537 - (56%)
Similarity:	397/537 - (73%)	Gaps:	3/537 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 GFTRLLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARLDQDLDKYMYLISLS 282
            |:....:...:||:|||.|||.||||||::|........|:........|...|||||:.|::|.
Human    50 GYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQ 114

  Fly   283 ERNERLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETD 347
            :|||:|||.||:||:...||:|||||||||||.|.|..:..:|:||:|.||||:..:|.:|||.:
Human   115 DRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDN 179

  Fly   348 VRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYI 412
            ::|:|||||||||||||||..|||||||||:||||..|:.|.||||:.||||||.|.:|.|||||
Human   180 IKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYI 244

  Fly   413 GLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTA 477
            ||:.:|..|..||:.:||||.|...:||.||||||||||||||||||:|||:.:|.|||||||||
Human   245 GLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTA 309

  Fly   478 SVAVAGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMVDSRGV 542
            ||||||:||:|:|.|.:|.::..:|.||||||:|||:|.:||::.||:.:.||..:||||||:|:
Human   310 SVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGL 374

  Fly   543 ITRDRPKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPI 607
            |.:.|  ..|...|..|||.|..:::|.|.||.|:|..:||.||..|||.::||..||..:|.||
Human   375 IVKGR--SHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPI 437

  Fly   608 IFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTY-NNKKFYPGQGNNSYIFPGVALGVLC 671
            ||||||||||||||||:.|..|:||.||||||||..||. :.|.|.||||||:|:||||||||:.
Human   438 IFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVALGVIA 502

  Fly   672 AGMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATVRPE 736
            .|:.:||:::||:.||::|:.||:..|::|.||||||:|...|:.||.::::||||:.||:..||
Human   503 GGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYKHNLASYYPE 567

  Fly   737 PVNKLAFIKAQMYDLDY 753
            |.:|.||:::.:|..||
Human   568 PKDKEAFVRSLVYTPDY 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	302/537 (56%)
		malic	282..463	CDD:278802	117/180 (65%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	150/277 (54%)
ME3	NP_001014811.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..50		302/537 (56%)
ME3	NP_001014811.1	PLN03129	38..588	CDD:215594	302/537 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159159
Domainoid	1	1.000	284	1.000	Domainoid score	I1639
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm8644
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2182
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.890