Protein Alignment Men and me1

DIOPT Version :9

• Sequence 1: NP_524880.2
• Gene: Men / 47173
• FlyBaseID: FBgn0002719
• Length: 763
• Species: Drosophila melanogaster
• Sequence 2: XP_002938500.1
• Gene: me1 / 100489590
• XenbaseID: XB-GENE-1013221
• Length: 589
• Species: Xenopus tropicalis
• Alignment Length: 550
• Identity: 314/550 - (57%)
• Similarity: 402/550 - (73%)
• Gaps: 13/550 - (2%)

  Fly   218 GFTRLLDKRYSKGLAFTHEERQQLGIHGMLPYVVREP---SEQVEHCRAL--LARLDQDLDKYMY 277
            |:....|...:||:||:.|||.||||||:||     |   |:.|:..|.|  ..|...|||:|:.
 Frog    33 GYDITRDPHLNKGMAFSLEERLQLGIHGLLP-----PCFLSQDVQVLRVLRNYERQKCDLDRYIL 92

  Fly   278 LISLSERNERLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKN 342
            |:.|.:|||:|||.||:|||...||:|||||||||||:|.|..:..:|:||:|.|:|||..|:|:
 Frog    93 LMGLQDRNEKLFYKVLTSDIERFMPVVYTPTVGLACQQYGLAFRRPRGLFITIHDRGHISTVMKS 157

  Fly   343 WPETDVRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILE 407
            |||.:::|:|||||||||||||||:.|||||||||:||||..|::|.:|||:.|||||:.:.:|.
 Frog   158 WPEDNIKAVVVTDGERILGLGDLGSYGMGIPVGKLALYTACGGVQPQECLPVMLDVGTDNQELLN 222

  Fly   408 DPLYIGLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDD 472
            ||||||||.||..|..|||.:||||.|...|:|.||||||||||||||||||:.||:.:||||||
 Frog   223 DPLYIGLRHRRVRGKEYDELVDEFMKAVTERYGINCLIQFEDFANANAFRLLNMYRNKYCTFNDD 287

  Fly   473 IQGTASVAVAGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMV 537
            |||||:|||||||.:|:|.|.:|.|:|:||.||||||:|||:|.:|||:.||...:.|...||||
 Frog   288 IQGTAAVAVAGLLGALRITKNKLSDHTVLFQGAGEAAMGIADLIVMAMEKEGTPRDAAIKNIWMV 352

  Fly   538 DSRGVITRDRPKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADI 602
            ||:|:|.:.|  ..|...|..||..|:.:.:|.|.|:.::|.||||.||.||||.::|::.||..
 Frog   353 DSKGLIVKGR--ASLNHEKERFAHPHKEMKSLEEVVKDIKPTVLIGVAAIGGAFTEQIIKDMASF 415

  Fly   603 NETPIIFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTY-NNKKFYPGQGNNSYIFPGVA 666
            |..||||||||||||||||||:.|..|:||.||||||||.|||. :.:..|||||||:|:|||||
 Frog   416 NNRPIIFALSNPTSKAECTAEQCYRLTQGRGIFASGSPFDPVTLPDGRTLYPGQGNNAYVFPGVA 480

  Fly   667 LGVLCAGMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLA 731
            |||:..|:.:|.:.|||..||.:|:.||...|.:|.|||||.:|...|:.||.:|||.|||:..|
 Frog   481 LGVVACGVRHISDDVFLTTAEIIAQQVSDKHLEEGRLYPPLQTIQEVSVKIAVKIVENAYKDNSA 545

  Fly   732 TVRPEPVNKLAFIKAQMYDLDYPRSVPATY 761
            :|.|||.||.||:::|||..||.:.:..:|
 Frog   546 SVFPEPENKEAFVRSQMYSTDYDQFMVDSY 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Men	NP_524880.2	PLN03129	213..757	CDD:215594	313/544 (58%)
		malic	282..463	CDD:278802	118/180 (66%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	155/277 (56%)
me1	XP_002938500.1	PLN03129	31..571	CDD:215594	313/544 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1650
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134785
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm9538
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.030