DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ebo and XPO1

DIOPT Version :9

Sequence 1:	NP_001284739.1	Gene:	ebo / 47141	FlyBaseID:	FBgn0266572	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_003391.1	Gene:	XPO1 / 7514	HGNCID:	12825	Length:	1071	Species:	Homo sapiens

Alignment Length:	1189	Identity:	224/1189 - (18%)
Similarity:	418/1189 - (35%)	Gaps:	361/1189 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ARKREIETNLLAFKSQPEAWQLCLRVATSSDTTENQFLWFFSTSTLEHTITRRWTQLTSTDKTLL 88
            |::|..:..|...|..|:||   .||.|..:.::|....::....||:.|..||..|.......:
Human    41 AQQRMAQEVLTHLKEHPDAW---TRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGI 102

  Fly    89 RETLWNSYAQLVATPNVAKRHRDTLAQLIALLG---KREFPEQDPNYMQHCMELTKTRFQLGIN- 149
            ::.:.....:..:.|...::.:..:.:|..:|.   |:|:|:..|.::...:..::|...|..|
Human   103 KKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNN 167

  Fly   150 --LLKITSEEVVS-NRGDLTTEWKQYFYSCISMCVPDVLDLVTKYLLIAVCHINGKDIQTTIPNT 211
              :||:.||||.. :.|.:|                   .:.:|:|..::|:           ..
Human   168 MVILKLLSEEVFDFSSGQIT-------------------QVKSKHLKDSMCN-----------EF 202

  Fly   212 LMDFSLTSALPNDNQLSSSILDLLGCVQHLVSWI------RTELISE--YFLMSILDLSQWRPAH 268
            ...|.|...:..::|.:..:...|..:...::||      .|:|||.  |..:::       |..
Human   203 SQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNV-------PMF 260

  Fly   269 EPISLAALSVLN-----------------ELLYLQKPLPFPGPLMGGVTSLLEQHNNNRRQSEMY 316
            ..:||..|:.:.                 .::.|::.||..       |::...::|.:...:
Human   261 RNVSLKCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPLN-------TNIRLAYSNGKDDEQ-- 316

  Fly   317 SDKFRELLRLYTTKYAAKLMQEPDLLETFLNLLYSCTTELHGALDFTEK---------LEIW--- 369
              .|.:.|.|:...:   |.:...|:|..|||..:....||..|..:|.         ||.|
Human   317 --NFIQNLSLFLCTF---LKEHDQLIEKRLNLRETLMEALHYMLLVSEVEETEIFKICLEYWNHL 376

  Fly   370 --------------TPIIKGIAQH---PAKITRYNNVLTQLVDEIMRRTQFEANKPELEVLDNEL 417
                          :|::.| :||   |.:...|..:|.::...::.|..    ||| |||   :
Human   377 AAELYRESPFSTSASPLLSG-SQHFDVPPRRQLYLPMLFKVRLLMVSRMA----KPE-EVL---V 432

  Fly   418 MEDDTSATEWQQFLDQCFESLALLANTRGAHIVFAQVYNHWSRPQMYLLSLEHALDHGSARSYEA 482
            :|:|..... ::|:... :|:.|..|.|              ...:||..|:: :|.....:.:.
Human   433 VENDQGEVV-REFMKDT-DSINLYKNMR--------------ETLVYLTHLDY-VDTERIMTEKL 480

  Fly   483 ARKLKGANVGEILRDFATVCQAVVRLAPLMDSSTAAPGVADEMECQLQMLSDSL--------LQT 539
            ..::.|....  .::..|:|.|:..::..|...       ||....:.::.|.|        ...
Human   481 HNQVNGTEWS--WKNLNTLCWAIGSISGAMHEE-------DEKRFLVTVIKDLLGLCEQKRGKDN 536

  Fly   540 LQLLASNRLYSGGSEMDKATFQTDLDNLYAQVLLAMRSIFPLTKAMSGEELLHRLFAILGSI--- 601
            ..::|||.:|..|.              |.:.|   |:.:...|.     ::::||..:...
Human   537 KAIIASNIMYIVGQ--------------YPRFL---RAHWKFLKT-----VVNKLFEFMHETHDG 579

  Fly   602 ---FACNGSLTAASP----IVQQAASELLLF-------ISTVIRPKCLLDIPQIQSLLQA-GSRL 651
               .||:..:..|..    .||....|::.|       |:|:|   |.|...|:.:..:| |..:
Human   580 VQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTII---CDLQPQQVHTFYEAVGYMI 641

  Fly   652 GAQLPRQVCINVHISLVSYMVLP---WKSVPEQ---------QQEYPRRLWML------------ 692
            |||..:.|  ..|: :..||:||   |.|:.:|         ..|..::|..:
Human   642 GAQTDQTV--QEHL-IEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVG 703

  Fly   693 REYVQGLAQNFLDL---------DLG---QANESKVAATTLSLLGTFTALIEYFKATGG-----N 740
            ..:|..|.:.:||:         ::.   |||...|....| :....|...|..|...|     |
Human   704 HPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPL-IRSMRTVKRETLKLISGWVSRSN 767

  Fly   741 AKDMLASTFKPILTKALMIFNNFGQSSIAMAITVAEFSLSMLRTLPTHLGAQFIKEMITLFISVS 805
            ...|:|..|.|.|..|::|                    ...|.:|                  :
Human   768 DPQMVAENFVPPLLDAVLI--------------------DYQRNVP------------------A 794

  Fly   806 SREQLTLSRLAVMEKILQMFKLIVEQPGSASLGLLPSILDFSTQQILPLLQQQNAATDNSEITSL 870
            :||...||.:|:          ||.:.|......:|.|.|...:..|.::.:.
Human   795 AREPEVLSTMAI----------IVNKLGGHITAEIPQIFDAVFECTLNMINKD------------ 837

  Fly   871 LYALFDSVLTCKWQFFYKNQLSNGHSGGGSGNFNCSDNLHPAHFMAILN----AYGQMLVSGTDP 931
                |:.....:..||...|..|.|.      |.....:.|..|..:|:    |:...:.:..|.
Human   838 ----FEEYPEHRTNFFLLLQAVNSHC------FPAFLAIPPTQFKLVLDSIIWAFKHTMRNVADT 892

  Fly   932 SNVRSVLFS-MQNVNER---SRLYQRALFKEQLL------------------ASFQRALLNLLLS 974
            .  ..:||: :|||.:.   ::.:.:..|.:.|.                  ||....:.||:..
Human   893 G--LQILFTLLQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEE 955

  Fly   975 GEGSLHFDMIAQALYAMGQVDRRQLLESFV----HASLPVAQTSLEEICQTNVLPFIVQDIPTFT 1035
            |:       |:.:|.....|:.:..|:.:|    .::.|..|.:..::..|.:.. :.||||.|.
Human   956 GK-------ISTSLNPGNPVNNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFS-LNQDIPAFK 1012

  Fly  1036 QKLTQLMQDAHCVHLNETA 1054
            :.|...:     |.:.|.|
Human  1013 EHLRDFL-----VQIKEFA 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ebo	NP_001284739.1	IBN_N	30..98	CDD:281761	15/67 (22%)
ebo	NP_001284739.1	Xpo1	110..259	CDD:285575	31/163 (19%)
XPO1	NP_003391.1	Necessary for HTLV-1 Rex-mediated mRNA export	1..679		146/754 (19%)
		CRM1	15..1044	CDD:227432	224/1189 (19%)
		Interaction with Ran and nuclear export complex formation	327..450		30/136 (22%)
		Interaction with RANBP3	411..481		19/94 (20%)
		Necessary for HTLV-1 Rex multimerization	411..414		0/2 (0%)
		HEAT 7	775..813		14/85 (16%)
		Interaction with HIV-1 Rev	800..820		6/29 (21%)
		HEAT 8	885..916		6/32 (19%)
		HEAT 9	917..954		6/36 (17%)
		HEAT 10	1002..1039		9/31 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900