back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ebo and Xpo5

DIOPT Version :9

Sequence 1:	NP_001284739.1	Gene:	ebo / 47141	FlyBaseID:	FBgn0266572	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_082474.1	Gene:	Xpo5 / 72322	MGIID:	1913789	Length:	1204	Species:	Mus musculus

Alignment Length:	1227	Identity:	230/1227 - (18%)
Similarity:	406/1227 - (33%)	Gaps:	425/1227 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VEGLLQEFYQPST-----SNARKREIETNLLAFKSQPEAWQLC-------LRVATSSDTTENQFL 61
            |..|.:|..:..|     |:.::..:|    |.|...|..:.|       |::|   :.|:...:
Mouse     6 VNALCEELVKAVTVMMDPSSTQRYRLE----ALKFCEEFKEKCPICVPCGLKLA---EKTQIAIV 63

  Fly    62 WFFSTSTLEHTITRRWTQLTSTDKTLLRETLWNSYAQLVATPNV----AKRH-RDTLAQLIALLG 121
            ..|....|||.:..||..::..:|..|:    ||..:|:|...:    .:.| :|.|::::..:.
Mouse    64 RHFGLQILEHVVKFRWNSMSRLEKVYLK----NSVMELIANGTLRILEEENHIKDVLSRIVVEMI 124

  Fly   122 KREFPEQDPNYMQHCMELT------KTRFQLGINLLKITSEEVVSNRGDLTTEWKQYFYSCISMC 180
            |||:|:..|:.:   |||.      :|:.:|.:.:|...:|:||:.: .|.|:.:
Mouse   125 KREWPQHWPDML---MELDTLFRQGETQRELVMFILLRLAEDVVTFQ-TLPTQRR---------- 175

  Fly   181 VPDVLDLVTKYLLIAVCHINGKDIQTTIPNTLMDFSLTSALPNDNQLSSSILD-LLGCVQHLVSW 244
                                 :|||.|:                .|....||: ||..:|
Mouse   176 ---------------------RDIQQTL----------------TQNMERILNFLLNTLQ----- 198

  Fly   245 IRTELISEYFLMSILDLSQWRPAHE--PISLAALSV---------LNE-------------LLYL 285
               |.:::|..|. .|.||...|..  .:|:|||:.         ||.             ||..
Mouse   199 ---ENVNKYQQMK-TDSSQEAEAQANCRVSVAALNTLAGYIDWVSLNHITAENCKLVETLCLLLN 259

  Fly   286 QKPLPFPGPLMGGVTSLL------EQHNNNRRQSEMYSDKFRELLRLYTTKYAAKLMQEPDLLE- 343
            ::.|.     :|....||      .:..:.:|...::.|     :.::....||:......|:|
Mouse   260 EQELQ-----LGAAECLLIAVSRKGKLEDRKRLMILFGD-----VAMHYILSAAQTADGGGLVEK 314

  Fly   344 --TFLNLLYSCTTELHG------ALDFTEKLEIWTPIIKGI--------AQHPAKITRYNNVLTQ 392
              .||..|......|..      |||    ..|.|||..|:        ..||::..|.:..:|.
Mouse   315 HYLFLKRLCQVLCALGNLLCALLALD----ANIQTPINFGMYLESFLAFTTHPSQFLRSSTHMTW 375

  Fly   393 LVDEIMRRTQFEANKPELEVLDNEL-------------MEDDTSATEWQQFLDQCFESLALLANT 444
              ..:.|......:...|.|:...|             .:.|:.:.|:.:|
Mouse   376 --GALFRHEVLSRDPALLAVIPKYLRASMTNLVKMGFPSKTDSPSCEYSRF-------------- 424

  Fly   445 RGAHIVFAQVYNHWSRPQMYLLSLEHALDHGSARSYEAARKLKGANVGEILRDFATVCQ------ 503
                                        |..|...:.|......|..||::|   .||:
Mouse   425 ----------------------------DFDSDEDFNAFFNSSRAQHGEVVR---CVCRLDPKTS 458

  Fly   504 -------------AVVRLAPLMDSSTAAPGVAD----------EMECQLQMLSDSLLQTLQLLAS 545
                         |.:...|:...|||..|...          :.|.....|...:.|..:.|..
Mouse   459 FQMAAEWLKYQLSASIDTGPVNSCSTAGTGEGGFCSIFSPSYVQWEAMTFFLESVINQMFRTLDK 523

  Fly   546 NRL-YSGGSEMDKATFQTDLDN--LYAQVLLAMRSIFPLT--KAMSGEELLHRLFAIL--GSIFA 603
            ..| .|.|.|:.:.....::.:  :.:.||..:.::||..  |.....::..:||:.:  .|:..
Mouse   524 EELPVSDGIELLQLVLNFEIKDPLVLSCVLTNVSALFPFVTYKPAFLPQVFSKLFSFVTFESVGE 588

  Fly   604 CNGSLTAASPIVQQAASELLLFISTVIRPKCLLDIPQIQSL------LQAGSRLGAQLPRQVCIN 662
            .....|.|...|::.|..   .|:.:.|....|.:|....|      |.:...|..|:.:  |
Mouse   589 SKAPRTRAVRNVRRHACS---SINKMCRDYPDLVLPNFDMLYSHVKQLLSNELLLTQMEK--C-- 646

  Fly   663 VHISLVSYMVLPWKSVPEQQQEYPRR-------------LWMLREYVQGLAQ-----NFLDLDLG 709
               :|:..:||    |..|.::|.|:             :|:..|..:.|:.     .::..||.
Mouse   647 ---ALMEALVL----VSNQFKDYERQKLFLEELMAPVVNIWLSEEMCRALSDIDSFIAYVGADLK 704

  Fly   710 QA----------NESKVAATTLSLLG-----TFTALIEYFKATG--------GNAKDMLASTFK- 750
            ..          |.::::....|:||     ::.:.:|..||.|        ||      ..|:
Mouse   705 SCDPAVEDPCGLNRARMSFCVYSILGVMRRTSWPSDLEEAKAGGFVVGYTPSGN------PIFRN 763

  Fly   751 PILTKALMIFNNFGQSSIAMAITVAEFSLSMLRTLPTHLGAQFIKEMITLFISVSSREQLTLSRL 815
            |...:.|.:.:|.               |:::||..|    .:..||:|     ...|..|
Mouse   764 PCTEQILRLLDNL---------------LALVRTHNT----LYTPEMLT-----KMAEPFT---- 800

  Fly   816 AVMEKILQMFKLIVEQPGSASLGLLPSILDFSTQQI----LPLLQQQNAATDNSEITSLLYALFD 876
                |.|.    |||...:|.|||...:|:|:...:    |..:|:         ...:||....
Mouse   801 ----KALD----IVESEKTAILGLPQPLLEFNDHPVYRTTLERMQR---------FFGILYENCY 848

  Fly   877 SVL-----TCKWQFFYKNQLSNGHSGGGSGNFNCSDNLHPAHFMAILNAYGQMLV-------SGT 929
            .:|     :.:..|:....|::...|....|.|   |:......::|..:.:.||       ..|
Mouse   849 HILGKAGPSMQQDFYTVEDLASQLLGSAFVNLN---NIPDFRLRSMLRVFVKPLVLFCPSEHYET 910

  Fly   930 DPSNVRSVLFSMQN---------VNERSRL-----------YQRALFKEQLLASFQRALLNLLLS 974
            ..|.:...||:..:         :|:||.|           ..:.:.:|||:....|..:
Mouse   911 LISPILGPLFTYLHMRLSQKWHVINQRSILCGEDEIAEDNPESQEMLEEQLVRMLTREAM----- 970

  Fly   975 GEGSLHFDMIAQALYAMGQVDRRQLLESFVHASLPVAQTSLEEICQTNVLPFIVQDI 1031
                   |:|.....:....|         |.:.|.|....||:..|.|.|..|.::
Mouse   971 -------DLIMACCVSKKTAD---------HTAAPTADGDDEEMMATEVAPSSVVEL 1011

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.