DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ebo and Ranbp21

DIOPT Version :9

Sequence 1:	NP_001284739.1	Gene:	ebo / 47141	FlyBaseID:	FBgn0266572	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_001285453.1	Gene:	Ranbp21 / 32970	FlyBaseID:	FBgn0031051	Length:	1241	Species:	Drosophila melanogaster

Alignment Length:	1171	Identity:	227/1171 - (19%)
Similarity:	377/1171 - (32%)	Gaps:	427/1171 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AASLTTVEGLLQEFYQPSTSNARKREIETNLLAFKSQ-PEAWQLCLRVATSSDTTENQFLWFFST 66
            ||.|.:...|:.   .|.|....:.|.......||.: |...|:.|.:|:|..:  ||.:..|..
  Fly    11 AAELASAIDLVM---NPMTQQQARLEAYMACERFKEESPMCAQVGLFLASSPQS--NQQVRHFGL 70

  Fly    67 STLEHTITRRWTQLTSTDKTLLRETLWNSYAQLVATPNVAKRH-----RDTLAQLIALLGKREFP 126
            ..:|:||..||..:|..:|..:::   |:...|......|:..     :|.|:::|..:.|||:|
  Fly    71 QLIEYTIKYRWNCITHEEKVYIKD---NAIKMLNVGVGPAEDRSLLPTKDALSRIIVEMIKREWP 132

  Fly   127 EQ--D--PNYMQHCMELTKTRFQLGINLLKITS--EEVVSNRGDLTTEWKQYFYSCISMCVPDVL 185
            :|  |  |...|.|   ||...|..:.||....  |:|...:...:.:.::..|..::..:.|:.
  Fly   133 QQWSDLLPELSQAC---TKGEAQTELVLLVFLRLVEDVALLQTIESNQRRKDMYQALNNNMNDIF 194

  Fly   186 DLVTKYLLIAVCHINGKDIQTTIPNTLMDFSLTSALPNDNQLSSSILDLLGCVQHLVSWIRTELI 250
            :.   :|.:...|:      |....|....:.|.|..:...:...:|.|.|    .|.|:..:.|
  Fly   195 EF---FLRLVEQHV------TAFRETTRLCNYTKANAHSRVVEMVLLTLSG----FVEWVSIQHI 246

  Fly   251 --SEYFLMSILDLSQWRPAHEPISLAALSVLNELLYLQKPLPFPGPLMGGVTSLLEQHNNNRRQS 313
              |...||..|.:                :||:..:           .......|.|..|.:.|:
  Fly   247 MSSNGKLMHFLCI----------------LLNDKAF-----------QCNAAECLAQITNRKGQT 284

  Fly   314 EMYSDKFRELLRLYTTKYAAKLMQEPDLLETFLNLLY---------SCTTELHGALDFTEKLEIW 369
            :    :.:.||:|:.        :||      |..:|         |.|..:...|:|.:||
  Fly   285 K----ERKPLLQLFN--------EEP------LRYIYQASQIPADTSSTLAVEQHLNFLKKL--- 328

  Fly   370 TPIIKGIAQHPAKITRYNNVLTQLVDEIMRRTQFEANKPELEVLDNELMEDDTSATEWQQFLDQC 434
            ..::.|:||             |||                     .|...| .||:....|:..
  Fly   329 LQVLNGMAQ-------------QLV---------------------ALWGKD-DATQRPVHLEVL 358

  Fly   435 FESLALLANTRGAHIVFAQVYNHWSRPQMYLLSLEHALDHGSARSYEAARKLKGANVGEILRDFA 499
            .|.|.||.                ..|.:       .|.||||..::...|.:.::     :|||
  Fly   359 LECLLLLV----------------QHPSL-------GLSHGSALIWQLLLKHEPSS-----KDFA 395

  Fly   500 ----------TVCQAVVRLAPLMDSSTAAPGVADE-----------------MECQLQMLSDSLL 537
                      |:...:|:| |...|:::...::.|                 ..|:...|....|
  Fly   396 MVNYIPKLIHTIAPRIVKL-PYPASASSPASLSTEAYIRLEHDSEEEYALYFFRCRTDFLEIFRL 459

  Fly   538 QTL---------------------QLLASNRLYSGG---SEMDKATFQTD-----LDNLYAQVLL 573
            .||                     |:.|...:.||.   |.:|....:.|     ||.:.:::||
  Fly   460 ATLVQPLVTYGYCEQWLQQRLRNAQIEADAEVKSGNVSCSVLDPVYLEWDALVSVLDGVLSRILL 524

  Fly   574 A------------------MRSIFPLTKAMSGEELLHRLFAILGSIFACNGSLTAASPIVQQAAS 620
            .                  :.:|.|||.::. ...:..||..| |:.||  .:||.:.:.....|
  Fly   525 VAERPSVPAGLRLLEECLKLETINPLTYSIL-LSCISALFVFL-SMSAC--QITATNCVAMSGVS 585

  Fly   621 EL-----LLFISTVIRPKCLLDIPQIQSLLQAGSRLGAQLPRQVCINVHISLVSYMVLPWKSVPE 680
            .|     .:|.:.|::|...|:..|.:|         |:..|:...::.:.|.
  Fly   586 LLPRVLDKIFRALVMKPPNELEKVQAKS---------AKNLRRHAASLLVKLA------------ 629

  Fly   681 QQQEYPRRLWMLREYVQGLAQNFLDLDLGQANESKVAATTLSLLGTFTALIEYFKATGGNAKDML 745
              .:||..|..:.|.:.|..:..|                              |..|   |..|
  Fly   630 --HKYPLLLLPVFEQINGHVELLL------------------------------KEPG---KHQL 659

  Fly   746 ASTFKPILTKALMIFNNFGQSSIAMAITVAEFSLSMLRTLPTHLGAQFIKEMITLFISVSSREQL 810
            ....:..|.:||::.:|.          ..:|                  |..||||
  Fly   660 CRLMRTTLQEALILISNH----------FCDF------------------ERQTLFI-------- 688

  Fly   811 TLSRLAVMEKILQMFKLIVEQPGSASLGLLPSILDFSTQQIL---PLLQQQNAAT--DNSEITSL 870
                    |.|:|..:......|.|    |.|.|||.:...|   |:...:.|.|  :.|.:...
  Fly   689 --------EHIVQDKRTEWLAFGDA----LKSPLDFMSFVGLDKPPIFAVEGAVTLQNRSRLLDA 741

  Fly   871 LYALFDSVLTCKWQFFYKNQLSNGHSGG------GSGNFNCSDNLHPA--HFMAILNAYGQMLVS 927
            |:.:...|..|.|    .:.......||      ..||..|.   :||  |.:.:|:
  Fly   742 LHVVLGVVKRCTW----PDDPERAQRGGFVIGCTELGNPICR---NPATKHIVPLLS-------- 791

  Fly   928 GTDPSNVRSVLFSMQNVNERSRLYQRALFKEQLLASFQRALLNLLLSGEGSLHFDMIAQALYAMG 992
                    .||..|:.:||        ||..:.|.:        |..|...:|           |
  Fly   792 --------HVLSLMRVLNE--------LFAPEALQA--------LSEGYRGIH-----------G 821

  Fly   993 QVDRRQLLESFVHASLPVAQTSLEEIC--QTNVLPFIVQDIPTFTQKLT--QLMQDAHCVHLNET 1053
            .::..:.|              |..||  .|:.|...::..||..:|:.  .:|....|.||..:
  Fly   822 MMEHEKKL--------------LMGICALPTDPLDTTIRSEPTAFEKMQTFMMMVTEGCYHLMGS 872

  Fly  1054 A 1054
            |
  Fly   873 A 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ebo	NP_001284739.1	IBN_N	30..98	CDD:281761	18/68 (26%)
ebo	NP_001284739.1	Xpo1	110..259	CDD:285575	36/156 (23%)
Ranbp21	NP_001285453.1	IBN_N	34..101	CDD:281761	18/71 (25%)
Ranbp21	NP_001285453.1	Xpo1	116..274	CDD:285575	39/200 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5101
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900