DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ebo and Xpo6

DIOPT Version :9

Sequence 1:	NP_001284739.1	Gene:	ebo / 47141	FlyBaseID:	FBgn0266572	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_001011935.2	Gene:	Xpo6 / 293476	RGDID:	1311491	Length:	1125	Species:	Rattus norvegicus

Alignment Length:	1184	Identity:	293/1184 - (24%)
Similarity:	510/1184 - (43%)	Gaps:	225/1184 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ASLTTVEGLLQEFYQPSTSNARKREIETNLLAFKSQPEAWQLCLRVATSSDTTENQFLWFFSTST 68
            |||..:|.|:.||:...|:|.||||||..|..|..|..||:.||...:|   |.|.::..:|.:.
  Rat     6 ASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQVGAWRFCLYFLSS---TRNDYVMMYSLTV 67

  Fly    69 LEHTITRRWTQLTSTDKTLLRETLWNSYAQLVATPNVAKRH--------RDTLAQLIALLGKREF 125
            .|:.|.:.|..:.|.||..:|..|          |.:...|        |:.|.::|..:|::::
  Rat    68 FENLINKMWLGVPSQDKMEIRSCL----------PKLLLAHHKTLPYFIRNKLCKVIVDIGRQDW 122

  Fly   126 PEQDPNYMQHCMELTKT--RFQLGINLLKITSEEVVSNRGDLTTEWKQYFYSCISMCVPDVLDLV 188
            |....::..:.::|.::  ...||:.:||.||||:...|.||:...|:.....:...|..||.|:
  Rat   123 PMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQVQTVLGLL 187

  Fly   189 TKYLLIAVCHINGKDIQTTIPNTLMD-FSLTSALPNDNQLSSSILDLLG---------------- 236
            |..|                 .|:.| .|:|:|.|..:..|....|||.
  Rat   188 TGIL-----------------ETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLHQPI 235

  Fly   237 ----------------CVQHLVSW------IRTELISEYF-------------LMSILDLSQ--- 263
                            |:.||.||      |...|::..|             :.|:...||
  Rat   236 PILDVESEYVCSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDTRARKMASVNGSSQNCV 300

  Fly   264 WRPAHEPISLAALSVLNELL-----------YLQKPLPFPGPLMGGVTSLLEQHNNNRRQSEM-- 315
            .......:.:.|:|.:|||:           ||.:.......|:..:|.....|....|..|:
  Rat   301 LGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRLEELDE 365

  Fly   316 -YSDKFRELLRLYTTKYAAKL---MQEPDLLETFLNLLYSCTTELHGALDFTEKLEIWT------ 370
             |.:||.:.|||:.:.:..::   .|.| :|| ||.||:..|........:...|:|||
  Rat   366 SYVEKFTDFLRLFVSVHLRRIESYSQFP-VLE-FLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYL 428

  Fly   371 --PIIKGIAQHPAKITRYNNVLTQLVDEIMRRTQFEANKPELEVLDNELMEDDTSATEWQQFLDQ 433
              .|...:....|.:.||.:.|..|:.|::.|.||..|:.:||.||:|.::|| ..||||::|.|
  Rat   429 TSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDDD-QQTEWQRYLRQ 492

  Fly   434 CFESLALLANTRGAHIVFAQVYNHWSRP------QMYLLSLEHALDHGSARSYEAARKLKGANVG 492
            ..|.:|.:......| .|:.::     |      ::||...:..:..||........:.....:.
  Rat   493 SLEVVAKVMELLPTH-AFSTLF-----PVLQDNLEVYLGLQQFVVTSGSGHRLNITAENDCRRLH 551

  Fly   493 EILRDFATVCQAVVRLAPLMDSSTAAPGVADEMECQLQMLSDSLLQTLQLLASNRLYSGGSEMDK 557
            ..|||.:::.|||.|||........|...:|            .|..::.|....||  ||::..
  Rat   552 CSLRDLSSLLQAVGRLAEYFTGDVFAARFSD------------ALTVVERLVKVTLY--GSQIKL 602

  Fly   558 ATFQT--------DLDNLYAQVLLAMRSIFPLTKAMSGEELLHR----LFAILGSIFACNGSLTA 610
            ...:|        ||.:::||.|.|:::..........|  .||    .|..|.|.     ::.|
  Rat   603 YNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCSE--AHRQNTQQFVTLIST-----TMDA 660

  Fly   611 ASPIVQQ--------AASELLLFISTVIRPKCLLDIPQIQ----SLLQAGSRLGAQLPRQVCINV 663
            .:|::..        :|..||:.::|.:||..|:.||.:|    |::.|.::   :|..:..:.|
  Rat   661 ITPLISTKVQDKLLLSACHLLVSLATTVRPVFLISIPAMQKVFNSIIDASAQ---RLTDKAQVLV 722

  Fly   664 HISLVSYMVLPWKSVPEQQQEYPRRLWMLREYVQGLAQNFLDLDLGQA--------NESKVAA-T 719
            ..:|.:.::|||.::||.:|::|.|.......:..|::::..|....|        :::||.. .
  Rat   723 CRALSNTLLLPWPNLPESEQQWPLRSINHASLISALSRDYHSLKPSAAAPQRKMPLDDTKVIIHQ 787

  Fly   720 TLSLLGTFTALIEYFKATGGNAKDMLASTFKPILTKALMIFNNF-GQSSIAMAITVAEFSLSMLR 783
            |||:   |..::|........::.:...:.:..:..:|.:|..| .||.:  ...:..|.|::.|
  Rat   788 TLSV---FEDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDV--TDEMLSFFLTLFR 847

  Fly   784 TLPTHLGAQFIKEMITLFISVSSREQLTLSRL-------AVMEKILQMFKLIVEQPGSASLGLLP 841
            .|...:|..|.:::|..|:::.:||||..|.|       .|:||.|::.:::|::||......||
  Rat   848 GLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLP 912

  Fly   842 SILDFSTQQILPLLQQQNAATDNSEITSLLYALFDSVLTCKWQFFYKNQ-LSNGHSGGGSGNFNC 905
            ||:....:|:.|::.::.:....:|:..||:    ..|...|::|:|:. |::...|.......
  Rat   913 SIIALCMEQVYPIIAERPSPDVKAELFELLF----RTLHHNWRYFFKSTVLASVQRGIAEEQME- 972

  Fly   906 SDNLHPAHFMAILNAYGQMLVSGTDPSNVRSVLFSMQNVNERSRLYQRALFKEQLLASFQRALLN 970
                :...|.||:.|:||..:. .|....:..||.::.:|.:.:||.:.:|:..:|..|...||.
  Rat   973 ----NEPQFSAIMQAFGQSFLQ-PDIHLFKQNLFYLETLNTKQKLYHKKIFRTTMLFQFVNVLLQ 1032

  Fly   971 LLLSGEGSLHFDMIAQALYAMGQVDRRQLLESFVHASLPVAQTSLE--EICQTNVLP---FIVQD 1030
            :|:.....|..:.|..|:|.|..||    .:.|..|.||...||.:  :..|.|||.   .:.:|
  Rat  1033 VLVHKSHDLLQEEIGIAIYNMASVD----FDGFFAAFLPEFLTSCDGVDANQKNVLGRNFKMDRD 1093

  Fly  1031 IPTFTQKLTQLMQD 1044
            :|:|||.:.:|:.|
  Rat  1094 LPSFTQNVHRLVND 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ebo	NP_001284739.1	IBN_N	30..98	CDD:281761	20/67 (30%)
ebo	NP_001284739.1	Xpo1	110..259	CDD:285575	43/202 (21%)
Xpo6	NP_001011935.2	IBN_N	31..96	CDD:197981	22/77 (29%)
Xpo6	NP_001011935.2	Xpo1	103..277	CDD:285575	42/190 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338187
Domainoid	1	1.000	195	1.000	Domainoid score	I3068
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3094
OMA	1	1.010	-	-		QHG55340
OrthoDB	1	1.010	-	-		D126286at33208
OrthoFinder	1	1.000	-	-		FOG0008925
OrthoInspector	1	1.000	-	-		oto96176
orthoMCL	1	0.900	-	-		OOG6_106208
Panther	1	1.100	-	-	LDO	PTHR21452
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.770