DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ebo and XPO6

DIOPT Version :9

Sequence 1:	NP_001284739.1	Gene:	ebo / 47141	FlyBaseID:	FBgn0266572	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_055986.1	Gene:	XPO6 / 23214	HGNCID:	19733	Length:	1125	Species:	Homo sapiens

Alignment Length:	1181	Identity:	287/1181 - (24%)
Similarity:	507/1181 - (42%)	Gaps:	219/1181 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ASLTTVEGLLQEFYQPSTSNARKREIETNLLAFKSQPEAWQLCLRVATSSDTTENQFLWFFSTST 68
            |||..:|.|:.||:...|:|.||||||..|..|..|..||:.||...:|   |.|.::..:|.:.
Human     6 ASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSS---TRNDYVMMYSLTV 67

  Fly    69 LEHTITRRWTQLTSTDKTLLRETLWNSYAQLVATPNVAKRH--------RDTLAQLIALLGKREF 125
            .|:.|.:.|..:.|.||..:|..|          |.:...|        |:.|.::|..:|::::
Human    68 FENLINKMWLGVPSQDKMEIRSCL----------PKLLLAHHKTLPYFIRNKLCKVIVDIGRQDW 122

  Fly   126 PEQDPNYMQHCMELTKT--RFQLGINLLKITSEEVVSNRGDLTTEWKQYFYSCISMCVPDVLDLV 188
            |....::..:.::|.::  ...||:.:||.||||:...|.||:...|:.....:...|..||.|:
Human   123 PMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQVQTVLGLL 187

  Fly   189 TKYLLIAVCHINGKDIQTTIPNTLMD-FSLTSALPNDNQLSSSILDLLG---------------- 236
            |..|                 .|:.| .|:|:|.|..:..|....|||.
Human   188 TGIL-----------------ETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLNQPI 235

  Fly   237 ----------------CVQHLVSW------IRTELISEYF-------------LMSILDLSQWRP 266
                            |:.||.||      |...|::..|             :.|:...||...
Human   236 PILDVESEYICSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDIRARKMASVNGSSQNCV 300

  Fly   267 AHEP---ISLAALSVLNELL-----------YLQKPLPFPGPLMGGVTSLLEQHNNNRRQSEM-- 315
            :.:.   :.:.|:|.:|||:           ||.:.......|:..:|.....|....|..|:
Human   301 SGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRLEELDE 365

  Fly   316 -YSDKFRELLRLYTTKYAAKL---MQEPDLLETFLNLLYSCTTELHGALDFTEKLEIWT------ 370
             |.:||.:.|||:.:.:..::   .|.|  :..||.||:..|........:...|:|||
Human   366 SYIEKFTDFLRLFVSVHLRRIESYSQFP--VVEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYL 428

  Fly   371 --PIIKGIAQHPAKITRYNNVLTQLVDEIMRRTQFEANKPELEVLDNELMEDDTSATEWQQFLDQ 433
              .|...:....|.:.||.:.|..|:.|::.|.||..|:.:||.||:|.::|| ..||||::|.|
Human   429 TSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDDD-QQTEWQRYLRQ 492

  Fly   434 CFESLALLANTRGAHIVFAQVYNHWSRP------QMYLLSLEHALDHGSARSYEAARKLKGANVG 492
            ..|.:|.:......| .|:.::     |      ::||...:..:..||........:.....:.
Human   493 SLEVVAKVMELLPTH-AFSTLF-----PVLQDNLEVYLGLQQFIVTSGSGHRLNITAENDCRRLH 551

  Fly   493 EILRDFATVCQAVVRLAPLMDSSTAAPGVADEMECQLQMLSDSLLQTLQLLASNRLYSGGSEMDK 557
            ..|||.:::.|||.|||........|....|            .|..::.|....||  ||::..
Human   552 CSLRDLSSLLQAVGRLAEYFIGDVFAARFND------------ALTVVERLVKVTLY--GSQIKL 602

  Fly   558 ATFQT--------DLDNLYAQVLLAMRSIFPLTKAMSGEELLHR----LFAILGSIFACNGSLTA 610
            ...:|        ||.:::||.|.|:::..........|  :||    .|..|.|.     ::.|
Human   603 YNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCSE--VHRQNTQQFVTLIST-----TMDA 660

  Fly   611 ASPIVQQ--------AASELLLFISTVIRPKCLLDIPQIQSLLQAGSRLGA-QLPRQVCINVHIS 666
            .:|::..        :|..||:.::|.:||..|:.||.:|.:....:...| :|..:..:.|..:
Human   661 ITPLISTKVQDKLLLSACHLLVSLATTVRPVFLISIPAVQKVFNRITDASALRLVDKAQVLVCRA 725

  Fly   667 LVSYMVLPWKSVPEQQQEYPRRLWMLREYVQGLAQNFLDLDLGQA--------NESK-VAATTLS 722
            |.:.::|||.::||.:|::|.|.......:..|::::.:|.....        :::| :...|||
Human   726 LSNILLLPWPNLPENEQQWPVRSINHASLISALSRDYRNLKPSAVAPQRKMPLDDTKLIIHQTLS 790

  Fly   723 LLGTFTALIEYFKATGGNAKDMLASTFKPILTKALMIFNNF-GQSSIAMAITVAEFSLSMLRTLP 786
            :|   ..::|........::.:...:.:..:..:|.:|..| .||.:  ...:..|.|::.|.|.
Human   791 VL---EDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDV--TDEMLSFFLTLFRGLR 850

  Fly   787 THLGAQFIKEMITLFISVSSREQLTLSRL-------AVMEKILQMFKLIVEQPGSASLGLLPSIL 844
            ..:|..|.:::|..|:::.:||||..|.|       .|:||.|::.:::|::||......||||:
Human   851 VQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSII 915

  Fly   845 DFSTQQILPLLQQQNAATDNSEITSLLYALFDSVLTCKWQFFYKNQ-LSNGHSGGGSGNFNCSDN 908
            ....:|:.|::.::.:....:|:..||:    ..|...|::|:|:. |::...|.......
Human   916 ALCMEQVYPIIAERPSPDVKAELFELLF----RTLHHNWRYFFKSTVLASVQRGIAEEQME---- 972

  Fly   909 LHPAHFMAILNAYGQMLVSGTDPSNVRSVLFSMQNVNERSRLYQRALFKEQLLASFQRALLNLLL 973
             :...|.||:.|:||..:. .|....:..||.::.:|.:.:||.:.:|:..:|..|...||.:|:
Human   973 -NEPQFSAIMQAFGQSFLQ-PDIHLFKQNLFYLETLNTKQKLYHKKIFRTAMLFQFVNVLLQVLV 1035

  Fly   974 SGEGSLHFDMIAQALYAMGQVDRRQLLESFVHASLPVAQTSLE--EICQTNVLP---FIVQDIPT 1033
            .....|..:.|..|:|.|..||    .:.|..|.||...||.:  :..|.:||.   .:.:|:|:
Human  1036 HKSHDLLQEEIGIAIYNMASVD----FDGFFAAFLPEFLTSCDGVDANQKSVLGRNFKMDRDLPS 1096

  Fly  1034 FTQKLTQLMQD 1044
            |||.:.:|:.|
Human  1097 FTQNVHRLVND 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ebo	NP_001284739.1	IBN_N	30..98	CDD:281761	20/67 (30%)
ebo	NP_001284739.1	Xpo1	110..259	CDD:285575	43/202 (21%)
XPO6	NP_055986.1	IBN_N	31..96	CDD:197981	22/77 (29%)
XPO6	NP_055986.1	Xpo1	103..253	CDD:369848	34/166 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144480
Domainoid	1	1.000	189	1.000	Domainoid score	I3298
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3243
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55340
OrthoDB	1	1.010	-	-		D126286at33208
OrthoFinder	1	1.000	-	-		FOG0008925
OrthoInspector	1	1.000	-	-		oto89048
orthoMCL	1	0.900	-	-		OOG6_106208
Panther	1	1.100	-	-	LDO	PTHR21452
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5865
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800