DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ebo and Xpo1

DIOPT Version :9

Sequence 1:	NP_001284739.1	Gene:	ebo / 47141	FlyBaseID:	FBgn0266572	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_001030303.1	Gene:	Xpo1 / 103573	MGIID:	2144013	Length:	1071	Species:	Mus musculus

Alignment Length:	1189	Identity:	224/1189 - (18%)
Similarity:	416/1189 - (34%)	Gaps:	361/1189 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ARKREIETNLLAFKSQPEAWQLCLRVATSSDTTENQFLWFFSTSTLEHTITRRWTQLTSTDKTLL 88
            |::|..:..|...|..|:||   .||.|..:.::|....::....||:.|..||..|.......:
Mouse    41 AQQRMAQEVLTHLKEHPDAW---TRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGI 102

  Fly    89 RETLWNSYAQLVATPNVAKRHRDTLAQLIALLG---KREFPEQDPNYMQHCMELTKTRFQLGIN- 149
            ::.:.....:..:.|...::.:..:.:|..:|.   |:|:|:..|.::...:..::|...|..|
Mouse   103 KKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNN 167

  Fly   150 --LLKITSEEVVS-NRGDLTTEWKQYFYSCISMCVPDVLDLVTKYLLIAVCHINGKDIQTTIPNT 211
              :||:.||||.. :.|.:|                               .:..|.::.::.|.
Mouse   168 MVILKLLSEEVFDFSSGQIT-------------------------------QVKAKHLKDSMCNE 201

  Fly   212 LMD-FSLTSALPNDNQLSSSILDLLGCVQHLVSWI------RTELISE--YFLMSI--------- 258
            ... |.|...:..::|.:..:...|..:...::||      .|:|||.  |..:::
Mouse   202 FSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSLK 266

  Fly   259 -------LDLSQWRPAHEPISLAALSVLNELLYLQKPLPFPGPLMGGVTSLLEQHNNNRRQSEMY 316
                   :.:||:....|.:....:..|.::|.|.             |::...::|.:...:
Mouse   267 CLTEIAGVSVSQYEEQFETLFTLTMMQLKQMLPLN-------------TNIRLAYSNGKDDEQ-- 316

  Fly   317 SDKFRELLRLYTTKYAAKLMQEPDLLETFLNLLYSCTTELHGALDFTEK---------LEIW--- 369
              .|.:.|.|:...:   |.:...|||..|||..:....||..|..:|.         ||.|
Mouse   317 --NFIQNLSLFLCTF---LKEHGQLLEKRLNLREALMEALHYMLLVSEVEETEIFKICLEYWNHL 376

  Fly   370 --------------TPIIKGIAQH---PAKITRYNNVLTQLVDEIMRRTQFEANKPELEVLDNEL 417
                          :|::.| :||   |.:...|..||:::...::.|..    ||| |||   :
Mouse   377 AAELYRESPFSTSASPLLSG-SQHFDIPPRRQLYLTVLSKVRLLMVSRMA----KPE-EVL---V 432

  Fly   418 MEDDTSATEWQQFLDQCFESLALLANTRGAHIVFAQVYNHWSRPQMYLLSLEHALDHGSARSYEA 482
            :|:|..... ::|:... :|:.|..|.|              ...:||..|:: :|.....:.:.
Mouse   433 VENDQGEVV-REFMKDT-DSINLYKNMR--------------ETLVYLTHLDY-VDTEIIMTKKL 480

  Fly   483 ARKLKGANVGEILRDFATVCQAVVRLAPLMDSSTAAPGVADEMECQLQMLSDSL--------LQT 539
            ..::.|....  .::..|:|.|:..::..|...       ||....:.::.|.|        ...
Mouse   481 QNQVNGTEWS--WKNLNTLCWAIGSISGAMHEE-------DEKRFLVTVIKDLLGLCEQKRGKDN 536

  Fly   540 LQLLASNRLYSGGSEMDKATFQTDLDNLYAQVLLAMRSIFPLTKAMSGEELLHRLFAILGSI--- 601
            ..::|||.:|..|.              |.:.|   |:.:...|.     ::::||..:...
Mouse   537 KAIIASNIMYIVGQ--------------YPRFL---RAHWKFLKT-----VVNKLFEFMHETHDG 579

  Fly   602 ---FACNGSLTAASP----IVQQAASELLLF-------ISTVIRPKCLLDIPQIQSLLQA-GSRL 651
               .||:..:..|..    .||....|::.|       |:|:|   |.|...|:.:..:| |..:
Mouse   580 VQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTII---CDLQPQQVHTFYEAVGYMI 641

  Fly   652 GAQLPRQVCINVHISLVSYMVLP---WKSVPEQ---------QQEYPRRLWML------------ 692
            |||..:.|  ..|: :..||:||   |.|:.:|         ..|..::|..:
Mouse   642 GAQTDQTV--QEHL-IEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVG 703

  Fly   693 REYVQGLAQNFLDL---------DLG---QANESKVAATTLSLLGTFTALIEYFKATGG-----N 740
            ..:|..|.:.:||:         ::.   |||...|....| :....|...|..|...|     |
Mouse   704 HPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPL-IRSMRTVKRETLKLISGWVSRSN 767

  Fly   741 AKDMLASTFKPILTKALMIFNNFGQSSIAMAITVAEFSLSMLRTLPTHLGAQFIKEMITLFISVS 805
            ...|:|..|.|.|..|::|                    ...|.:|                  :
Mouse   768 DPQMVAENFVPPLLDAVLI--------------------DYQRNVP------------------A 794

  Fly   806 SREQLTLSRLAVMEKILQMFKLIVEQPGSASLGLLPSILDFSTQQILPLLQQQNAATDNSEITSL 870
            :||...||.:|:          ||.:.|......:|.|.|...:..|.::.:.
Mouse   795 AREPEVLSTMAI----------IVNKLGGHITAEIPQIFDAVFECTLNMINKD------------ 837

  Fly   871 LYALFDSVLTCKWQFFYKNQLSNGHSGGGSGNFNCSDNLHPAHFMAILN----AYGQMLVSGTDP 931
                |:.....:..||...|..|.|.      |.....:.||.|..:|:    |:...:.:..|.
Mouse   838 ----FEEYPEHRTNFFLLLQAVNSHC------FPAFLAIPPAQFKLVLDSIIWAFKHTMRNVADT 892

  Fly   932 SNVRSVLFS-MQNVNER---SRLYQRALFKEQLL------------------ASFQRALLNLLLS 974
            .  ..:||: :|||.:.   ::.:.:..|.:.|.                  ||....:.||:..
Mouse   893 G--LQILFTLLQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEE 955

  Fly   975 GEGSLHFDMIAQALYAMGQVDRRQLLESFV----HASLPVAQTSLEEICQTNVLPFIVQDIPTFT 1035
            |:       |:..|.....|:.:..::.:|    .::.|..|.:..::..|.:.. :.||||.|.
Mouse   956 GK-------ISTPLNPGNPVNNQMFIQDYVANLLKSAFPHLQDAQVKLFVTGLFS-LNQDIPAFK 1012

  Fly  1036 QKLTQLMQDAHCVHLNETA 1054
            :.|...:     |.:.|.|
Mouse  1013 EHLRDFL-----VQIKEFA 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ebo	NP_001284739.1	IBN_N	30..98	CDD:281761	15/67 (22%)
ebo	NP_001284739.1	Xpo1	110..259	CDD:285575	30/180 (17%)
Xpo1	NP_001030303.1	CRM1	15..1044	CDD:227432	224/1189 (19%)
		HEAT 1	217..240		4/22 (18%)
		HEAT 2	241..277		5/35 (14%)
		Necessary for interaction with Ran and nuclear export complex formation. /evidence=ECO:0000250	327..450		32/136 (24%)
		HEAT 3	354..472		30/143 (21%)
		Necessary for interaction with RANBP3. /evidence=ECO:0000250	411..481		20/94 (21%)
		HEAT 4	515..553		8/51 (16%)
		HEAT 5	560..597		6/41 (15%)
		HEAT 6	602..639		9/39 (23%)
		HEAT 7	775..813		14/85 (16%)
		HEAT 8	885..916		6/32 (19%)
		HEAT 9	917..954		6/36 (17%)
		HEAT 10	1002..1039		9/31 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900