DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment knk and Skeletor

DIOPT Version :9

Sequence 1:	NP_649981.1	Gene:	knk / 47137	FlyBaseID:	FBgn0001321	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_001247027.1	Gene:	Skeletor / 3772559	FlyBaseID:	FBgn0262717	Length:	1503	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	267/759 - (35%)
Similarity:	386/759 - (50%)	Gaps:	96/759 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLCLRLQHHLLLVILTIFLLCPAASAQNEEEDGPYRGKYLGKLNSYHHQVSGDVYAVNEYTFLIV 71
            :|.::.:..|||..|...|.|.|:..   :...||.|..:|.|...||.||||||||:..|..|.
  Fly     1 MLAMKDKPWLLLFGLLAALSCLASFG---DAAYPYYGTKIGALTRLHHGVSGDVYAVDSRTIFIK 62

  Fly    72 GFNYDGNGADTFFWSGASNRPGPQGFI-VPDEYGKT-NILDRYHNKDFTLTLPDRKKITEIKWLA 134
            .|||||.....:|:.|.:.||..:|.. :.||.|.| ::..||.|||.||:||:.|.:.:|||.:
  Fly    63 KFNYDGEAPAAYFYVGNTARPSNEGAARLRDERGGTASLTRRYRNKDVTLSLPEGKTLRDIKWFS 127

  Fly   135 VYDLSSQNNFGDVYIPEEFDPP----MSQLGGTFSKRSHNVSSSSVEILDSKTIRIKDFTYDGRG 195
            |:......|||||.||...|.|    :|.|.|.     |.|||.::.|:|::|:.:.:|:|||..
  Fly   128 VWCDEFAVNFGDVSIPPNLDFPRPQKISALRGV-----HGVSSDNIVIVDAQTLLVPNFSYDGEA 187

  Fly   196 KRTFFWTGVGPQPSSRGSKLPDERGYLDPIRQYNKETIELELPGDKTIFDIDWISVYDVADNENY 260
            ....||.|.|.:|:|.|.::|||.|..:|:|:|.::||.|.||.|.|||||....|:..|...::
  Fly   188 PDAKFWVGRGQRPTSDGLRIPDENGKENPLRRYERKTIVLTLPEDLTIFDIGHFGVWCEAFTVDF 252

  Fly   261 GHVLFNDKLNVPPSLVKVTPFEFSLPNCRQLHKDM--QVSWEVFGPQITFQLSGQVGGNDYMSFG 323
            |||...:.|||||||..:.....|..||..|:.|:  :|.|.|.|..|..||..::..|.|||||
  Fly   253 GHVRLPEGLNVPPSLKMLGISPQSKLNCEVLYDDLAFEVRWAVAGESIVVQLVAKLEPNHYMSFG 317

  Fly   324 ISGSDVSSQMIGSDVVVAYIDDI--RGYTVDYNITSLAPCVQVLGQNKGVCRDDVVG-GLDSFQL 385
            ||.:...|||||:|.|||::|..  .|:..||.:...|.|    ...:|.|.|..:. ..:|.:|
  Fly   318 ISPNKNISQMIGADAVVAWVDPQTGNGFATDYFLEGKAQC----SGGRGACPDTKISEKTNSIRL 378

  Fly   386 NTYSRKDGINTISFRRTLKSSDDGDKEIFLDRSNYVIWAFGPLDSNNEPAFHTYYPKSDIVIDF- 449
            ...:..:|.:.::::|:|.::|..|..|.:..:..|:||.|||:...|.:|||:|.|....|:|
  Fly   379 LNAAMVNGYSIVTYQRSLAATDRLDLPISITGAESVVWAIGPLNDYQEVSFHTFYNKHLHQIEFG 443

  Fly   450 -----------------NTTEPVNDCFA------------------------FTKRAETTN--PP 471
                             |::|..:...|                        :..|||..:  ||
  Fly   444 RQPKWNCPLPEGARGNSNSSEQEDSAPAAQSSTGGAGYPPAGRPNVEPDEEFYENRAEALHRQPP 508

  Fly   472 -------------------------VWERTRIT--DATVRTFNAYLGPSGGLRGYQGLTNHVSSG 509
                                     .|:...|.  :.....|.|.:||:||..||..:|.||..|
  Fly   509 QRRQETAIITQRRPVPTPKPVNSNGAWDIPAIQCHEPEDGVFYAQMGPTGGKHGYPAITGHVGWG 573

  Fly   510 LAWYINGYMIPELYLKRGLTYTFKVRGGNNPHSPEHYHPLVITDDPQGGYDRLSDAKQSEIRVLA 574
            ::|||||.:|||:::.||.||||.|.|||||..|..|||..|:|||.|||:...:.::..:|:.|
  Fly   574 ISWYINGLLIPEIHVVRGKTYTFVVEGGNNPDIPAKYHPFYISDDPVGGYEHKREEEKKAVRIYA 638

  Fly   575 GVEFTRRGRPKPTAAGPLCLSRYPQNSDRRLDDNFPTFKKFNRSLITECVEGEPALLEITPNITW 639
            ||..:|.|:..||..|.||  .:..:.:....|::.:|..:.|:|..:|..|||.::...|:...
  Fly   639 GVHRSRSGQVTPTGVGRLC--NWTPDVEGPPADDYQSFGAYQRTLTLKCDAGEPGVITWKPDRNT 701

  Fly   640 PDTVYYNSFTHGNMGWKIHIVDSYTNLKSGSMGLSWSLCIILLP 683
            ||||||:.|||..:|||||:.||..:...|..|.:.....|.||
  Fly   702 PDTVYYHCFTHRYLGWKIHVHDSCDSEAGGLKGAASERHEIRLP 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
knk	NP_649981.1	DM13	51..156	CDD:128929	48/106 (45%)
		DM13	166..272	CDD:128929	43/105 (41%)
		DoH	292..454	CDD:214768	57/184 (31%)
Skeletor	NP_001247027.1	DM13	42..149	CDD:128929	48/106 (45%)
		DM13	158..264	CDD:128929	44/110 (40%)
		DoH	286..447	CDD:214768	56/164 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	0.167	Domainoid score	I6519
eggNOG	1	0.900	-	-		E1_KOG4731
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11322at50557
OrthoFinder	1	1.000	-	-		FOG0005930
OrthoInspector	1	1.000	-	-		otm2993
orthoMCL	1	0.900	-	-		OOG6_105978
Panther	1	1.100	-	-	P	PTHR24036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5705
	9	8.820