DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment knk and Thbd

DIOPT Version :9

Sequence 1:	NP_649981.1	Gene:	knk / 47137	FlyBaseID:	FBgn0001321	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_033404.1	Gene:	Thbd / 21824	MGIID:	98736	Length:	577	Species:	Mus musculus

Alignment Length:	181	Identity:	35/181 - (19%)
Similarity:	53/181 - (29%)	Gaps:	70/181 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 NDCFAFTKRAETTNPPVWERTRITDATVRTFNAYLGPSGGLRGYQGLTNHVSSGLAWYINGYMIP 520
            ::|||..:...|                     :|..|...:..||....|.|.:|..:...::.
Mouse    33 HECFALFQGPAT---------------------FLDASQACQRLQGHLMTVRSSVAADVISLLLS 76

  Fly   521 ELYLKRGLTYTFKVRGGNNPHSPEHYHPL----VITDDPQGGYDRLSDAKQSEIRVLAGVEFTRR 581
            :..:..|.....::..|.:  .|.|..||    .:|.|....|.|.:
Mouse    77 QSSMDLGPWIGLQLPQGCD--DPVHLGPLRGFQWVTGDNHTSYSRWA------------------ 121

  Fly   582 GRPKPTAA---GPLCLSRYPQNSDRRLDDNFPTFKKFNRSLITECVEGEPA 629
             ||....|   ||||::                     .|..||...||||
Mouse   122 -RPNDQTAPLCGPLCVT---------------------VSTATEAAPGEPA 150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
knk	NP_649981.1	DM13	51..156	CDD:128929
		DM13	166..272	CDD:128929
		DoH	292..454	CDD:214768
Thbd	NP_033404.1	CLECT	30..169	CDD:295302	35/181 (19%)
		FXa_inhibition	244..279	CDD:291342
		FXa_inhibition	291..322	CDD:291342
		EGF_CA	324..360	CDD:284955
		Plasmod_Pvs28	346..467	CDD:283826
		Tme5_EGF_like	405..438	CDD:286192
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849253
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030