Protein Alignment knk and W01C8.5

DIOPT Version :9

• Sequence 1: NP_649981.1
• Gene: knk / 47137
• FlyBaseID: FBgn0001321
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: NP_508959.1
• Gene: W01C8.5 / 180836
• WormBaseID: WBGene00020921
• Length: 511
• Species: Caenorhabditis elegans
• Alignment Length: 689
• Identity: 161/689 - (23%)
• Similarity: 238/689 - (34%)
• Gaps: 243/689 - (35%)

  Fly    20 ILTIFLLCPAASAQNEEEDGPYR---GKYLGKLNSYHHQVSGDVYAVNEYTFLIVGFNYDGNGAD 81
            ::.|..|..|||:....:...|.   |.|:|.|:|....:||.|:.||..|..|....:..:..|
 Worm     5 LVQIVFLSLAASSTYCYDINTYNADYGVYVGDLSSPETDISGQVFIVNATTLQIFNLTFSPSQQD 69

  Fly    82 TFFWSGASNRPGPQGFIVPD-EYGKTNILDRYHNKD-FTLTLPDRKKITEIKWLAVYDLSSQNNF 144
            .:||....:.|..:|..... |||.|.:.....:.| ..:.:|::.:|.|.|..::|...:..:.
 Worm    70 LYFWLDTKDVPTREGIKAHTFEYGITPLGSFPEDNDRVVVHVPEKHRIDEFKSFSIYSFKTDKSM 134

  Fly   145 GDVYIPEEFDPPMS-QLGGTFSKRSHNVSSSSVEILDSKTIRIKDFTYDG-RGKRTFFWTGVGPQ 207
            ..|..||....|.| :|...||.:.:.:.|..:.::|.:||::..||::| :..:|:|:.|.|..
 Worm   135 ASVVFPENVKIPKSVKLSTEFSGKRYQLRSGPLYVIDRRTIKVYGFTFEGNKAPKTYFYAGRGAS 199

  Fly   208 PS-SRGSKL----PDERGYLDPIRQY--NKETIELELPGDKTIFDIDWISVYDVADNENYGHVLF 265
            .| |.|.|:    .||:...:....|  .|:.| ||||.:..||.|||||||......|:|.||.
 Worm   200 VSYSSGVKVAIRGKDEKEISEISENYRGGKDII-LELPENYDIFHIDWISVYCYKYRVNFGSVLV 263

  Fly   266 --NDKL-NVPPSLVKVTPFEFSLPNCRQLHKDMQVSWEVFGPQITFQLSGQVGGNDYMSFGISGS 327
              :|.| |:||
 Worm   264 PTDDTLVNLPP------------------------------------------------------ 274

  Fly   328 DVSSQMIGSDVVVAYIDDIRGYTVDYNITSLAPCVQVLGQNKGVCRDDVVGGLDSFQLNTYSRKD 392
                          |:..|:..|                ..|.:.|
 Worm   275 --------------YVPSIKKNT----------------DGKPMAR------------------- 290

  Fly   393 GINTISFRRTLKSSDDGDKEIFLDRSNYVIWAFGPLDSNNEPAFHTYYPKSDIVIDFNTTEPVND 457
            |:        ||.|
 Worm   291 GV--------LKGS--------------------------------------------------- 296

  Fly   458 CFAFTKRAETTNPPVWERTRITDATVRTFNAYLGPSGGLRGYQGLTNHVSSGLAWYINGYMIPEL 522
                   ||.||                |...||....::...|  |..|....|::|..|.|:|
 Worm   297 -------AERTN----------------FTFQLGDVEHIKNLNG--NLRSPKYVWHVNSVMSPDL 336

  Fly   523 YLKRGLTYTFKVRGGNNPHSPEHYHPLVITDDPQGGYDRLS--DAKQSEIRVLAGVEFTRRGRPK 585
            ||.|.:||.|.|.||.....||.|:||.|.||..||:..||  :|::..|.....:|
 Worm   337 YLMRNVTYNFNVEGGREKMIPELYNPLYIGDDENGGFSELSQNEAERVTIHSPGLIE-------- 393

  Fly   586 PTAAGPLCLSRYPQNSDRRLDDNFPTFKKFNRSLITECVEGEPA---LLEITPNITWPDTVYYNS 647
             :..||||:  :..|.|:..::         .....|| :|.|.   ....|||.|.|..:||||
 Worm   394 -SNTGPLCI--WMHNKDKAANE---------PDTYLEC-DGWPEDVHSFAFTPNETTPSVLYYNS 445

  Fly   648 FTHGNMGWKIHIVDS------------YTNLKSGSMGLS 674
            ..:.|||.:|.|||.            |:..|..::.||
 Worm   446 GNNFNMGGRIFIVDELPENIADSAEVPYSREKWHTLALS 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
knk	NP_649981.1	DM13	51..156	CDD:128929	26/106 (25%)
		DM13	166..272	CDD:128929	40/116 (34%)
		DoH	292..454	CDD:214768	9/161 (6%)
W01C8.5	NP_508959.1	DM13	38..146	CDD:128929	26/107 (24%)
		DM13	160..264	CDD:383103	37/104 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166404
Domainoid	1	1.000	82	1.000	Domainoid score	I5397
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I2608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005930
OrthoInspector	1	1.000	-	-		otm14242
orthoMCL	1	0.900	-	-		OOG6_105978
Panther	1	1.100	-	-	O	PTHR24036
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17027
SonicParanoid	1	1.000	-	-		X5705
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.920