DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dup and Cdt1

DIOPT Version :9

Sequence 1:	NP_001286451.1	Gene:	dup / 47121	FlyBaseID:	FBgn0000996	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_080290.3	Gene:	Cdt1 / 67177	MGIID:	1914427	Length:	557	Species:	Mus musculus

Alignment Length:	678	Identity:	197/678 - (29%)
Similarity:	309/678 - (45%)	Gaps:	166/678 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 LIVTAAQESKKKTPAAAKMEPHIKQPKLVQFIKKGTLSP--RKQAQSSKLDE--EELQQSSAISE 134
            |:..|...|..:..|....||...||           :|  |::.:...||.  ..|.:.|:.:|
Mouse    34 LVAPAFTRSSSRKRARPPAEPGSDQP-----------APLARRRLRLPGLDSCPSSLPEPSSPAE 87

  Fly   135 HTPKVNFTITSQQNADNVQRGLRTPTKQILKDASPIKADLRRQLTFDEVKTKVSRSAKLQELKAV 199
            .:|..:    ....||        |...:.  .||:|......:...:...|:.....:.||::.
Mouse    88 PSPPAD----PSPPAD--------PGSPVC--PSPVKRTKSTTVYVGQQPGKIPSEDSVSELQSC 138

  Fly   200 LALKAALEQKRKEQEERNRKLRDAGPSPSKSKMSVQLKEFDTIELEVLISPLKTFKTPTKIPPPT 264
            |                 |:.|..|......:..||                     ...:.|.|
Mouse   139 L-----------------RRARKLGAQARALRARVQ---------------------ENAVEPST 165

  Fly   265 PDKHELMSPRHTDVSKRLLFSPAKNGSPVKLVE-VPAYKRYASLVESSRAGQLPLPYKYRHLLDV 328
            ||                    ||..:....|| .|||:|:.:|.:....| |.|||||:.|:::
Mouse   166 PD--------------------AKVPTEQPCVEKAPAYQRFHALAQPGLPG-LVLPYKYQVLVEM 209

  Fly   329 FKGLDSVVAMFHNRKETITFKKLKPAVQRMLRKNFTETHLAQIKHIYPDAFIFSQ---VKTRNFG 390
            |:.:|::|:|.|||.||:||.|:|..||.|:||.|.|.::.|||.:||.::.|.|   |.|.. .
Mouse   210 FRSMDTIVSMLHNRSETVTFAKVKQGVQEMMRKRFEERNVGQIKTVYPTSYRFRQECNVPTFK-D 273

  Fly   391 SVSKADYFQLIIAPNVEPLPEQQQSEKPQHFTKINEDDVLASAQSTSMNPHVMTARMQRFQSLLL 455
            |:.::|| ||    .:|||..|:                  :..:|.:....:..|.|.|:..|:
Mouse   274 SIKRSDY-QL----TIEPLLGQE------------------AGGATQLTATCLLQRRQVFRQNLV 315

  Fly   456 DRAMRAHDQFLRSQDPPIII-EKALTRWHPQFDLESCPEVELSPLPQPPNVEKYSSAKDILSTAR 519
            :|....|..||.|.:||:.: :..||||||:|:::..|::|.:.|||||..||.::|:::|:.||
Mouse   316 ERVKEQHKVFLASLNPPMAVPDDQLTRWHPRFNVDEVPDIEPAELPQPPVTEKLTTAQEVLARAR 380

  Fly   520 NLFNCATP-MERAMDRYEAKLESEKQQAAESNKKTEEQQAGEVTRTSTAIQTSQEVPGISGSSKN 583
            :|.   || ||:|:                               ::.|:::::  ||..|:|..
Mouse   381 SLM---TPKMEKAL-------------------------------SNLALRSAE--PGSPGTSTP 409

  Fly   584 PTVPETTNQTETAKPTVKDCTVPDASSNLLKGLPKSLIEKIRAKQAAKALEAMTRRPSQDQEATK 648
            |.            |.....|.|.||.:.|||:.::|:|:||||:..|.|..|||.|.|:....:
Mouse   410 PL------------PATPPATPPAASPSALKGVSQALLERIRAKEVQKQLARMTRCPEQELRLQR 462

  Fly   649 YSRLPELARHLRNVFVTERKGVLTLEVIIKKIQNSFRANLTPQEIEAHLKLLAKELPSWASFHEV 713
            ..|||||||.||||||:|||..||:||:..::.:|.:..|:|.|:|.||.|||:.||.|.|.|.:
Mouse   463 LERLPELARVLRNVFVSERKPALTMEVVCARMVDSCQTALSPGEMEKHLVLLAELLPDWLSLHRI 527

  Fly   714 RKTMYLKVAKDMDMNKIIEKLESVANAK 741
            |...|:|:.|.:|:..:..:|....:|:
Mouse   528 RTDTYVKLDKAVDLAGLTARLAHHVHAE 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dup	NP_001286451.1	CDT1	318..500	CDD:285985	65/185 (35%)
dup	NP_001286451.1	Cdt1_c	610..735	CDD:176572	56/124 (45%)
Cdt1	NP_080290.3	PIP-box K+4 motif. /evidence=ECO:0000250\|UniProtKB:Q9H211	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..113		22/103 (21%)
		Cyclin-binding motif. /evidence=ECO:0000250\|UniProtKB:Q9H211	65..67		0/1 (0%)
		Interaction with GMNN. /evidence=ECO:0000250\|UniProtKB:Q9H211	163..203		18/60 (30%)
		Cdt1_m	181..364	CDD:176571	75/207 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..427		10/43 (23%)
		Cdt1_c	427..549	CDD:176572	56/121 (46%)
		Interaction with LRWD1. /evidence=ECO:0000250\|UniProtKB:Q9H211	463..557		42/93 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847429
Domainoid	1	1.000	116	1.000	Domainoid score	I5949
eggNOG	1	0.900	-	-		E1_KOG4762
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3235
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007528
OrthoInspector	1	1.000	-	-		oto92161
orthoMCL	1	0.900	-	-		OOG6_105773
Panther	1	1.100	-	-	LDO	PTHR28637
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4071
SonicParanoid	1	1.000	-	-		X6418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780