DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dup and cdt-1

DIOPT Version :9

Sequence 1:	NP_001286451.1	Gene:	dup / 47121	FlyBaseID:	FBgn0000996	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001040707.1	Gene:	cdt-1 / 171896	WormBaseID:	WBGene00000413	Length:	684	Species:	Caenorhabditis elegans

Alignment Length:	785	Identity:	177/785 - (22%)
Similarity:	302/785 - (38%)	Gaps:	205/785 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QPSVAAFF-TNRKRAALDDAISIKNRRLVEPAETVSPASAPSQLPAGDQDADLDTLKAAATGMRT 66
            |.:|..|| |.||..|..:      :::::.:.|.:......|:|             ||..:..
Worm    14 QTAVTDFFKTTRKPRARGE------KKIIDESITKTTTIKEVQIP-------------AAPIVEN 59

  Fly    67 RSGRTARLIVTAAQESKKKTPAAAKMEPHIKQPKLVQFIKKGTLSPRKQAQSSKLDEEELQQSSA 131
            :|.||           :.:||:           :..:....||  |.|:|:.::.:..||
Worm    60 KSSRT-----------RARTPS-----------RQAELSSSGT--PPKKAREAEAEAPEL----- 95

  Fly   132 ISEHTPKVNFTITSQQNADNVQRGLRTPTKQILKDASPIKADLRRQLTFDEVKTKVSRSAKLQEL 196
                 ||::..|                   ||::.:|.|:.:.:.:.......|.:....:.:|
Worm    96 -----PKIHEDI-------------------ILENPAPQKSAIDKLMEASGPAKKKAGIRTVADL 136

  Fly   197 KAVLALKAA--------LEQKRKEQEERNRKLR--------DAGPSPSKSKMSVQLKEFDTIELE 245
            :|.:|.|.|        |:.|.|:.::....|:        :...||.|||.:..|........:
Worm   137 QARIAAKGAAKAIHEQNLKNKTKQVDDHVELLKSPKKPVIVEHHKSPQKSKAARNLFSPKKPVPD 201

  Fly   246 VLISPLKTFKTPTKIPPPTPDKHELMSPRHTDVSKRLLFSPAKNGSPVKLVEVPAYKRYASLVES 310
            .:|......|:..|:.....|.||       :..||:.....|:            .|....|:.
Worm   202 YIIPGFNVLKSAEKVRGEQDDAHE-------EEGKRMTAEFLKS------------SRLIDEVKE 247

  Fly   311 SRAGQLPLPYKYRHLLDVFKGLDSVVAMFHNRKETITFKKLKPAVQRMLRKNFTETHLAQIKHIY 375
            |...::.||..|.||.|.||.:|.:.|:|..:..:....:|...|:....|:|:..||:||.|:|
Worm   248 SARQRIELPTAYEHLADTFKRIDQITAIFIGQNRSCVVPELIKNVKNTSGKDFSNEHLSQILHVY 312

  Fly   376 PDAF-IFSQVKTRNFGSVSKADYFQLIIAPN-VEPLPEQQQSEKPQHFTKINEDDVLASAQSTSM 438
            |.:: |..:.:.:.||...|   ::|.:.|| ||.|......:.|   |..:.:|:.....|..:
Worm   313 PQSYHIEMREQRKAFGQGGK---YELEVRPNLVEDLRGYIYEKSP---TDGDTEDLPLVCPSKLL 371

  Fly   439 NPHV--------------------MTARMQR-----FQSLLLDRAMRAHDQFLRSQDPPIIIEKA 478
            :|..                    :.|..||     |:..|.....:.|.:||.||.  :.....
Worm   372 SPKKSPRKQVQPALRKPEVDGRIRLDAARQRDRAHVFRYKLASIVTKCHTEFLESQG--LCASSN 434

  Fly   479 LTRWHPQFDLES-CPEVELSPLPQPPNVEKYSSAKDILSTARNLFNCATPMERAMDRY--EAKLE 540
            :.|.||.|.|:. ||.:....||:|| ::|.|              ....|:.|:|:|  :..|.
Worm   435 IKRMHPLFRLDKHCPSLPQVKLPEPP-LQKSS--------------IHIGMKEALDKYMDQVSLP 484

  Fly   541 SEKQQAAESNKKTEEQQAGEVTRTSTAIQTSQEVPGISGSSKNPTVPETTNQTETAKPTVKDCTV 605
            |..|:|.:..|..        .:::|         |.||     |||.:..:....:...|.
Worm   485 SFVQKAYQDLKSP--------LKSTT---------GASG-----TVPISPKKFSEMQKEQKS--- 524

  Fly   606 PDASSNLLKGLPKSLIEKIRAKQA-AKALEAMTRRPSQDQEATKYSRLPELA-RHLR---NVFVT 665
                    :| ..||:|:||||:| .||.||..   .:|.|..| .||..|. |::|   |.:..
Worm   525 --------QG-AMSLLERIRAKEAIKKAAEACI---DKDLERRK-QRLTLLRDRYVRIVCNHYTA 576

  Fly   666 ERKGVLTLEVIIKKIQNSFRANLTPQEIEAHLKLLAKELPSWASFHEVRKTMYLKVAKDMDMNKI 730
            :|...:.::||.|.:|.|...:.:..:|..||:||.:..|.:.|...:....|.:.. |.::..|
Worm   577 KRAQTMEIDVICKFVQFSSSNSSSIPDIMDHLRLLCEVAPMYISEASLMNKKYFRFT-DNNIEAI 640

  Fly   731 IEKLE 735
            .|.|:
Worm   641 NELLD 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dup	NP_001286451.1	CDT1	318..500	CDD:285985	54/209 (26%)
dup	NP_001286451.1	Cdt1_c	610..735	CDD:176572	39/129 (30%)
cdt-1	NP_001040707.1	CDT1	255..457	CDD:370147	54/209 (26%)
cdt-1	NP_001040707.1	Cdt1_c	520..645	CDD:176572	40/141 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165226
Domainoid	1	1.000	59	1.000	Domainoid score	I7131
eggNOG	1	0.900	-	-		E1_KOG4762
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I3697
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007528
OrthoInspector	1	1.000	-	-		oto18236
orthoMCL	1	0.900	-	-		OOG6_105773
Panther	1	1.100	-	-	LDO	PTHR28637
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4071
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.780