DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dup and cdt1

DIOPT Version :9

Sequence 1:	NP_001286451.1	Gene:	dup / 47121	FlyBaseID:	FBgn0000996	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	XP_002933700.2	Gene:	cdt1 / 100379812	XenbaseID:	XB-GENE-1014888	Length:	617	Species:	Xenopus tropicalis

Alignment Length:	780	Identity:	246/780 - (31%)
Similarity:	356/780 - (45%)	Gaps:	222/780 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAQPSVAAFFTNRKRAALDDAISIKNRRLVEPA----ETVSPASAPSQLPAGDQDADLDTLKAAA 61
            |:|..|..||...||.:   |.....||..||.    .||:.:.|.|             :||..
Frog     4 MSQMRVTDFFAQSKRGS---AAQNSKRRKAEPVLETRRTVTRSKAAS-------------IKAEE 52

  Fly    62 TGMRTRSGRT-ARLIVTAAQ-----ESKKKTPAAAKMEPHIKQPKLVQFIKKGTLSPRKQAQSS- 119
            .   .||.|| .|...|..|     .|||:....:..||               |..::|.:|:
Frog    53 I---LRSPRTPERNSPTVTQSFLGPSSKKRARHDSDSEP---------------LRTQRQGKSAR 99

  Fly   120 ---KLDEEE----LQQ--SS-----AISEHTPK---------VNFTITSQQNADNVQRGLRTP-T 160
               ||.|.|    :||  ||     |:...||.         ||.:::.:.|  .::|...|| |
Frog   100 KKLKLPEGEDGGLVQQKISSPCNKVALEHATPSSLGKKIKDMVNVSLSPKLN--ELERNQTTPET 162

  Fly   161 KQILKDASP-IKADLRRQLTFDEVKTKVSRSAKLQELKAVLA-LKAALEQKRKEQEERNRKLRDA 223
            |...|:..| :|:.|:|   ..|:..||:......|.|..:| |||.|    |..:|.:.|:|
Frog   163 KAPAKENLPELKSRLQR---IQELAQKVNLPVASSEGKVTIADLKARL----KRAQELDTKIR-- 218

  Fly   224 GPSPSKSKMSVQLKEFDTIELEVLISPLKTFKTPTKIPPPTPDKHELMSPRHTDVSKRLLFSPAK 288
                  :|...|:.||                    ..||..:..
Frog   219 ------AKTDTQVVEF--------------------TQPPAQESE-------------------- 237

  Fly   289 NGSPVKLVEVPAYKRYASLVESSRAGQLPLPYKYRHLLDVFKGLDSVVAMFHNRKETITFKKLKP 353
                    :.|||:|:.:|.:.:..| |.|||||:.|.::|:.:|::|.|..||.|||||.|:|.
Frog   238 --------KAPAYQRFHNLAQDTAPG-LSLPYKYKVLAEMFRSMDTIVGMLFNRSETITFSKVKQ 293

  Fly   354 AVQRMLRKNFTETHLAQIKHIYPDAFIFSQVK---TRNFGSVSKADYFQLIIAPNVEPLPEQQQS 415
            .||.|:||.|.:.::.|||.:||.|:.:.|.|   |...| |.|.|| ||    .::||
Frog   294 GVQDMMRKQFEQRNVGQIKTVYPTAYKYRQEKNIPTFKDG-VKKTDY-QL----TIDPL------ 346

  Fly   416 EKPQHFTKINEDDVLASAQSTSMNPHV----MTARMQRFQSLLLDRAMRAHDQFLRSQDPPIII- 475
                    |:|.|.|      :..||:    :..|.|.|...|.....:.|..||.|.:||:::
Frog   347 --------IDEGDKL------NGRPHLSASSLLQRRQLFHRSLTSIVKQHHKVFLASLNPPMVVP 397

  Fly   476 EKALTRWHPQFDLESCPEVELSPLPQPPNVEKYSSAKDILSTARNLFNCATP-MERAMDRYEAKL 539
            :..||||||:|:::..|:|..|.||.||.|||.::|:::||.||.:.   || ||:|:
Frog   398 DDKLTRWHPRFNVDEVPDVMPSELPLPPQVEKLTTAQEVLSKARGMI---TPKMEKAL------- 452

  Fly   540 ESEKQQAAESNKKTEEQQAGEVTRTSTAIQTSQEVPGISGSSKNPTVPETTNQTETAKPTVKDCT 604
                                    .:.|::|::.    :|..||.: .|.|....||
Frog   453 ------------------------ANLALKTAEN----AGEPKNVS-SEETKSAATA-------- 480

  Fly   605 VPDASSNLLKGLPKSLIEKIRAKQAAKALEAMTRRPSQDQEATKYSRLPELARHLRNVFVTERKG 669
               ::||.|||:.:||:|:||||:|.|....|||||.|::.....||||||||.||||||.|:|.
Frog   481 ---STSNALKGVSQSLLERIRAKEAQKLQAMMTRRPQQEERLLMMSRLPELARILRNVFVAEKKP 542

  Fly   670 VLTLEVIIKKIQNSFRANLTPQEIEAHLKLLAKELPSWASFHEVRKTMYLKVAKDMDMNKIIEKL 734
            .|||||...::.:|:|::::|.|:|.||.||::.||.|.|.|.:||..|.|:.|.||:|.|||:|
Frog   543 ALTLEVTCNRVISSYRSSMSPGEMEKHLALLSEILPDWLSIHPIRKDTYYKLNKSMDLNLIIERL 607

Fly 735 734
Frog 608 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dup	NP_001286451.1	CDT1	318..500	CDD:285985	69/189 (37%)
dup	NP_001286451.1	Cdt1_c	610..735	CDD:176572	67/125 (54%)
cdt1	XP_002933700.2	Cdt1_m	240..425	CDD:176571	78/211 (37%)
cdt1	XP_002933700.2	Cdt1_c	483..608	CDD:176572	67/125 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6445
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3092
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D218447at33208
OrthoFinder	1	1.000	-	-		FOG0007528
OrthoInspector	1	1.000	-	-		oto102468
Panther	1	1.100	-	-	LDO	PTHR28637
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4071
SonicParanoid	1	1.000	-	-		X6418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100