DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and TRIP13

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_004228.1	Gene:	TRIP13 / 9319	HGNCID:	12307	Length:	432	Species:	Homo sapiens

Alignment Length:	457	Identity:	89/457 - (19%)
Similarity:	163/457 - (35%)	Gaps:	115/457 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VGDFPEEIKYADISPAPGQHFIFALEKTVEVPSGYVGFSLVQRKWAMVSINQELEVRPYRFDASS 89
            |||..:.:.....||            ||.|.....|.|..:::...:|:.:.|.    |.:...
Human     5 VGDLKQALPCVAESP------------TVHVEVHQRGSSTAKKEDINLSVRKLLN----RHNIVF 53

  Fly    90 DVITCVSFETDFLQKKTVSQEPYDSDQMAKEFIMQFAGMALTVGQSLVFNFKDKKLLGLAVKSLE 154
            ...|...|:..||.:...|....|::                                |.||..:
Human    54 GDYTWTEFDEPFLTRNVQSVSIIDTE--------------------------------LKVKDSQ 86

  Fly   155 AIDPKSLGEGKDTAMRNVRFGRILGNTVVQFEKAENSSLNLQGKSKGKVVRQSIINPDWDFGKMG 219
            .||..:.    ..|:.           :.|..:...||.||:.:::..:.....:.|..:|
Human    87 PIDLSAC----TVALH-----------IFQLNEDGPSSENLEEETENIIAANHWVLPAAEF---- 132

  Fly   220 IGGL------DKEFNS-IFRRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTML 277
             .||      |.|..| :......:.:|..:.|........:.:||:||||||||.:.:.:...|
Human   133 -HGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKL 196

  Fly   278 NAR--------EPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAIC 334
            ..|        :...:|...:..|:..||...|.::|.:.::   .:.....|..::.||::::.
Human   197 TIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQD---LIDDKDALVFVLIDEVESLT 258

  Fly   335 KQRGSVAGNSGVHDT--VVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISL 397
            ..|.:....:...|.  |||.:||:||.:.:.:|::::..:|..:.||.|.:  .|.:::..|..
Human   259 AARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFV--DRADIKQYIGP 321

  Fly   398 PNEQG--------------------RVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELE 442
            |:...                    |.|:|.     :||...|....:|....:|..|....:.|
Human   322 PSAAAIFKIYLSCLEELMKCQIIYPRQQLLT-----LRELEMIGFIENNVSKLSLLLNDISRKSE 381

  Fly   443 GL 444
            ||
Human   382 GL 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012	12/57 (21%)
		CDC48_2	111..>158	CDD:215011	5/46 (11%)
		SpoVK	242..699	CDD:223540	51/233 (22%)
		AAA	256..397	CDD:278434	37/150 (25%)
		AAA	539..668	CDD:278434
TRIP13	NP_004228.1	SpoVK	<136..360	CDD:223540	48/233 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810