DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and PEX6

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_014070.1	Gene:	PEX6 / 855387	SGDID:	S000005273	Length:	1030	Species:	Saccharomyces cerevisiae

Alignment Length:	532	Identity:	153/532 - (28%)
Similarity:	232/532 - (43%)	Gaps:	115/532 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VNVGDFPEEIKYA-----DISPA--------PGQHFIFALEKTVEVPSGYVGFSLVQRKWAMVSI 74
            ||....||.||..     ::|..        ||..|:.::.....|||   .|....|...:|.:
Yeast   557 VNANQDPEAIKLQKSINFEMSKLLDDFTFKFPGTTFVGSVNNIDNVPS---SFRSHMRFEILVPV 618

  Fly    75 NQELE-VRPYRFDASSDVITCVSFETDFLQKKTVSQEPYDSDQMAKEFIMQFAGMALTVGQSLVF 138
            ..|.: :|.:::..||.     ....|..||..||.    .|.::...:..::.
Yeast   619 PSEAQRLRIFQWYLSSH-----ELNRDVQQKVPVSY----MDNISFSSLSSYSA----------- 663

  Fly   139 NFKDKKLLGLAVKSLEAIDPKSLGE-GKDTAMRNVRF-------GRILGNTVVQFEKAENSSLNL 195
                         .|..:|.||:.| .:.||  ..||       |.:..:.::..|....::...
Yeast   664 -------------GLTPLDIKSIVETARMTA--TARFYQESKKCGWLPQSILITQEDLSKATSKA 713

  Fly   196 QGKSKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYG 260
            :.:....:....|.|..||    .|||:|.....|. ......:..|||... |.|...|||.||
Yeast   714 RNEFSVSIGAPQIPNVTWD----DIGGIDFVKGEIL-DTIDMPLKHPELFTS-GMKKRSGILFYG 772

  Fly   261 PPGTGKTLMARQIGT--MLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLH 323
            ||||||||||:.|.|  .||...   |.||::|:.|:|||||||||:|.:|.|.:.        .
Yeast   773 PPGTGKTLMAKAIATNFSLNFFS---VKGPELLNMYIGESEANVRRVFQKAREAKP--------C 826

  Fly   324 IIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVD-QLNNILVIGMTNRRDMIDEALLRPG 387
            :|.|||||::..:||:...:.||.|.:|:|||.::||:. ..:.:.|||.|||.|::||||||||
Yeast   827 VIFFDEIDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMSTDADGVFVIGATNRPDLLDEALLRPG 891

  Fly   388 RLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTK-NFSGAELEGLVRAAQSS 451
            |.:..:.:.:|:..  .:.|||.....|:| .:::||...|:|.|.. |::||:...|...|..:
Yeast   892 RFDKLLYLGIPDTD--TKQLNILEALTRKF-VLDNDVKLIELAKLCPFNYTGADFYALCSDAMLN 953

  Fly   452 AMNRLIK-ADAKVTVDPEAM------------------EKLKVNRDDFLHSLEHDIKPAFGTAQE 497
            ||:|:.: .:.||:...|..                  .|:.|..:|||            .|||
Yeast   954 AMSRIARMVEKKVSQHNELTGENISTRRWFDKIATKEDTKVVVKMEDFL------------KAQE 1006

  Fly   498 ILDNMLARGVIN 509
            .|...::|..:|
Yeast  1007 QLTPSVSRAELN 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012	18/73 (25%)
		CDC48_2	111..>158	CDD:215011	2/46 (4%)
		SpoVK	242..699	CDD:223540	107/291 (37%)
		AAA	256..397	CDD:278434	68/143 (48%)
		AAA	539..668	CDD:278434
PEX6	NP_014070.1	SpoVK	540..1017	CDD:223540	152/529 (29%)
PEX6	NP_014070.1	RecA-like_PEX6_r2	740..899	CDD:410935	75/171 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810