DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and PEX1

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_012724.1	Gene:	PEX1 / 853636	SGDID:	S000001680	Length:	1043	Species:	Saccharomyces cerevisiae

Alignment Length:	511	Identity:	134/511 - (26%)
Similarity:	209/511 - (40%)	Gaps:	161/511 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 KEFIMQFAGMALTVGQSLVFNFKDKKLLGLAVKSLEAI---------DPKSLGEGKDTAMRNVRF 174
            ::.||::.......|.||:           .:.::||:         ||.:.|:. |.|.:.:.|
Yeast   504 QKLIMEWCSFCYWYGPSLI-----------VLDNVEALFGKPQANDGDPSNNGQW-DNASKLLNF 556

  Fly   175 G---------------RIL--GNTVVQ-----FEK---AENSSLNLQGK-----------SKGKV 203
            .               |:|  |....|     |:|   :|..||....|           ||.::
Yeast   557 FINQVTKIFNKDNKRIRVLFSGKQKTQINPLLFDKHFVSETWSLRAPDKHARAKLLEYFFSKNQI 621

  Fly   204 VRQSIINPDWDFGKM-----GIGGLDKEF----------------NSIFRRAFASRV--FPPELV 245
            ::   :|.|..|..:     |...||.|.                |.:.|..|:..:  |.|..:
Yeast   622 MK---LNRDLQFSDLSLETEGFSPLDLEIFTEKIFYDLQLERDCDNVVTRELFSKSLSAFTPSAL 683

  Fly   246 EQLGCKHVK------------------------------------------GILLYGPPGTGKTL 268
            .  |.|..|                                          ||||||.||.||||
Yeast   684 R--GVKLTKETNIKWGDIGALANAKDVLLETLEWPTKYEPIFVNCPLRLRSGILLYGYPGCGKTL 746

  Fly   269 MARQIGTM--LNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEID 331
            :|..:...  ||...   |.||:||:|::|.||.|:|.||..|:..:.        .|:.|||.|
Yeast   747 LASAVAQQCGLNFIS---VKGPEILNKFIGASEQNIRELFERAQSVKP--------CILFFDEFD 800

  Fly   332 AICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEIS 396
            :|..:||.  .::||.|.|||||||::||.:.|:.:.::..|:|.|:||.||||||||:..:..:
Yeast   801 SIAPKRGH--DSTGVTDRVVNQLLTQMDGAEGLDGVYILAATSRPDLIDSALLRPGRLDKSVICN 863

  Fly   397 LPNEQGRVQILN--IHTKRMREFNK---INDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNRL 456
            :|.|..|:.||.  :::|......|   :..:.|.|.||..|..||||:|:||...|...:::|.
Yeast   864 IPTESERLDILQAIVNSKDKDTGQKKFALEKNADLKLIAEKTAGFSGADLQGLCYNAYLKSVHRW 928

  Fly   457 IKADAKVTVDP--EAMEKLKVN----RDD--------FLHSLEHDIKPAFGTAQEI 498
            :.|..:..|.|  :.:|...:|    |::        ....:.|:.|.:...|.|:
Yeast   929 LSAADQSEVVPGNDNIEYFSINEHGRREENRLRLKTLLQQDVVHETKTSTSAASEL 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	7/47 (15%)
		SpoVK	242..699	CDD:223540	98/320 (31%)
		AAA	256..397	CDD:278434	62/142 (44%)
		AAA	539..668	CDD:278434
PEX1	NP_012724.1	PEX-1N	108..183	CDD:401267
		SpoVK	457..929	CDD:223540	124/454 (27%)
		RecA-like_PEX1_r2	705..862	CDD:410934	63/169 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810