DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and MSP1

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_011542.3	Gene:	MSP1 / 852915	SGDID:	S000003260	Length:	362	Species:	Saccharomyces cerevisiae

Alignment Length:	395	Identity:	113/395 - (28%)
Similarity:	177/395 - (44%)	Gaps:	68/395 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 MAKEF-IMQFAGMALTVGQSLVFNFKDKKLLG------LAVKSLEAIDPKSLGEGKDTAMRNVRF 174
            |:::| :.....:::.||..:...:...:||.      |:.||.|:...:||
Yeast     1 MSRKFDLKTITDLSVLVGTGISLYYLVSRLLNDVESGPLSGKSRESKAKQSL------------- 52

  Fly   175 GRILGNTVVQFEKAENSSLNLQG---KSKGKVVRQSIINPD-WDFGKMGIGGLDKEFNSIFRRAF 235
                     |:||....|..|..   .:..:.:..||:.|| .:.....|||||...:.:..
Yeast    53 ---------QWEKLVKRSPALAEVTLDAYERTILSSIVTPDEINITFQDIGGLDPLISDLHE--- 105

  Fly   236 ASRVFP---PELVEQLGCKHV-KGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVG 296
             |.::|   ||:......... .|:|||||||.|||::|:.:.....|....| ....|:||:.|
Yeast   106 -SVIYPLMMPEVYSNSPLLQAPSGVLLYGPPGCGKTMLAKALAKESGANFISI-RMSSIMDKWYG 168

  Fly   297 ESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGV 361
            ||...|..:|:.|    .:|.|    .||..||||:..::|.|.  :..|..|:..:.:|..||:
Yeast   169 ESNKIVDAMFSLA----NKLQP----CIIFIDEIDSFLRERSST--DHEVTATLKAEFMTLWDGL 223

  Fly   362 DQLNN--ILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDV 424
              |||  :::||.|||.:.||:|.||  ||..:..:|||....|.:||::   .:::.....|:.
Yeast   224 --LNNGRVMIIGATNRINDIDDAFLR--RLPKRFLVSLPGSDQRYKILSV---LLKDTKLDEDEF 281

  Fly   425 DNKEIAALTKNFSGAELEGLVRAAQSSAMNRLIKADAKV----TVDPEAMEKLKV---NRDDFLH 482
            |.:.||..||.|||::|:.|.|.|...|....||...::    |:|......||:   ...||..
Yeast   282 DLQLIADNTKGFSGSDLKELCREAALDAAKEYIKQKRQLIDSGTIDVNDTSSLKIRPLKTKDFTK 346

  Fly   483 SLEHD 487
            .|..|
Yeast   347 KLRMD 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	10/47 (21%)
		SpoVK	242..699	CDD:223540	85/256 (33%)
		AAA	256..397	CDD:278434	52/142 (37%)
		AAA	539..668	CDD:278434
MSP1	NP_011542.3	MDN1	<10..>164	CDD:227596	43/180 (24%)
		RecA-like_ATAD1	92..255	CDD:410928	62/181 (34%)
		AAA_lid_3	280..319	CDD:407720	15/38 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810