Protein Alignment comt and SEC18

DIOPT Version :10

• Sequence 1: NP_524877.1
• Gene: comt / 47091
• FlyBaseID: FBgn0000346
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_009636.3
• Gene: SEC18 / 852372
• SGDID: S000000284
• Length: 758
• Species: Saccharomyces cerevisiae
• Alignment Length: 729
• Identity: 324/729 - (44%)
• Similarity: 476/729 - (65%)
• Gaps: 25/729 - (3%)

  Fly     5 LKATKCPTDELSLTNRAIVNVGDFPEEIKYADISPAPGQHFIFALEKTVEVPSGYVGFSLVQRKW 69
            ||.:.||.:..:|.|.|.|:..|||..| |..|.    ..|:|....:.::|.|.:||:..||.|
Yeast    29 LKVSNCPNNSYALANVAAVSPNDFPNNI-YIIID----NLFVFTTRHSNDIPPGTIGFNGNQRTW 88

  Fly    70 AMVSINQELEVRP---YRFDASSDVITCVSFETDFLQKKTVSQEPYDSDQMAKEFIMQFAGMALT 131
            ...|:||:::.:.   :::......:..:..:..|..:.......:|.|::||:|:..:.....:
Yeast    89 GGWSLNQDVQAKAFDLFKYSGKQSYLGSIDIDISFRARGKAVSTVFDQDELAKQFVRCYESQIFS 153

  Fly   132 VGQSLVFNFKDKKLLGLAVKSLEAID-----PKS-LGEGKDTAMRNVRFGRILGNTVVQFEKAEN 190
            ..|.|:..|:. ....|.:::::|||     |.| :..|.:|.      |.:...|.:.|.|..:
Yeast   154 PTQYLIMEFQG-HFFDLKIRNVQAIDLGDIEPTSAVATGIETK------GILTKQTQINFFKGRD 211

  Fly   191 SSLNLQGKSKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKG 255
            ..:||:..:..:....::|.||:.|..:|:|||||||..|||||||||:|||.::|:||..||||
Yeast   212 GLVNLKSSNSLRPRSNAVIRPDFKFEDLGVGGLDKEFTKIFRRAFASRIFPPSVIEKLGISHVKG 276

  Fly   256 ILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNS 320
            :||||||||||||:||:|||||||:||||||||:||.||||.||.|:|.||.:||.|.:..|..|
Yeast   277 LLLYGPPGTGKTLIARKIGTMLNAKEPKIVNGPEILSKYVGSSEENIRNLFKDAEAEYRAKGEES 341

  Fly   321 GLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLR 385
            .||||||||:|::.|||||....:||.|.||||||.|:|||||||||||||||||:|:||.||||
Yeast   342 SLHIIIFDELDSVFKQRGSRGDGTGVGDNVVNQLLAKMDGVDQLNNILVIGMTNRKDLIDSALLR 406

  Fly   386 PGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQS 450
            |||.|||:||.||:|:||:||.:|.||:|||.|.::|||:..|:|||||||||||:||||::|.|
Yeast   407 PGRFEVQVEIHLPDEKGRLQIFDIQTKKMRENNMMSDDVNLAELAALTKNFSGAEIEGLVKSASS 471

  Fly   451 SAMNRLIKADAKVT-VDPEAMEKLKVNRDDFLHSLEHDIKPAFGTAQEILDNMLARGVINWGAPV 514
            .|:|:.:......| ::.:.:.||||.|:|||::| :|:.||||.::|.|...:..|::.:...|
Yeast   472 FAINKTVNIGKGATKLNTKDIAKLKVTREDFLNAL-NDVTPAFGISEEDLKTCVEGGMMLYSERV 535

  Fly   515 SNLLEDGMLYVQQAKAPESSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDMVGYTES 579
            :::|::|..||:|.:..:.|.|||:|:.|...||||||||::|..|.|||:::.||.::.|.:||
Yeast   536 NSILKNGARYVRQVRESDKSRLVSLLIHGPAGSGKTALAAEIALKSGFPFIRLISPNELSGMSES 600

  Fly   580 AKCLHIRKIFDDAYRSMLSCIVVDNVERLLDYGSIGPRYSNMTLQALLVLLKKQPPKGRKLLILC 644
            ||..:|...|.|||:|.|:.:|:|::|.|:|:..||||:||..||.|.|.||::||:.|:|||:.
Yeast   601 AKIAYIDNTFRDAYKSPLNILVIDSLETLVDWVPIGPRFSNNILQMLKVALKRKPPQDRRLLIMT 665

  Fly   645 TSSRREVLEEMEMLTAFTSVLHVPNLSKPDHVLAV-LENTDIFSKGEIQAIGKKMAGKRVF-IGI 707
            |:|...||::|::|:.|.:.:.|||::..|.:..| :|:..:...|.::.|.:.......| :||
Yeast   666 TTSAYSVLQQMDILSCFDNEIAVPNMTNLDELNNVMIESNFLDDAGRVKVINELSRSCPNFNVGI 730

  Fly   708 KKLLGLIDMARQTE 721
            ||.|..|:.||..|
Yeast   731 KKTLTNIETARHDE 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_524877.1	CDC48_N	5..83	CDD:215012	26/80 (33%)
		CDC48_2	111..>158	CDD:215011	12/51 (24%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	127/175 (73%)
		CDC48	<220..>606	CDD:273521	224/386 (58%)
		SpoVK	<526..702	CDD:440232	72/176 (41%)
SEC18	NP_009636.3	CDC48_N	29..98	CDD:215012	26/73 (36%)
		CDC48_2	134..204	CDD:215011	18/76 (24%)
		CDC48	<232..>629	CDD:273521	229/397 (58%)
		RecA-like_NSF-SEC18_r1-like	240..416	CDD:410912	127/175 (73%)