Protein Alignment comt and CDC48

DIOPT Version :9

• Sequence 1: NP_001259506.1
• Gene: comt / 47091
• FlyBaseID: FBgn0000346
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_010157.1
• Gene: CDC48 / 851431
• SGDID: S000002284
• Length: 835
• Species: Saccharomyces cerevisiae
• Alignment Length: 597
• Identity: 175/597 - (29%)
• Similarity: 277/597 - (46%)
• Gaps: 87/597 - (14%)

  Fly   169 MRNVRFGRILGNTVVQFEK------AENSSLNLQGKSKGKVVRQSIINPDWDFGKMGIGGLDKEF 227
            ||.|.|      .||..|.      |:::.::.:|:...:...::.:|   :.|...|||..|:.
Yeast   168 MRQVEF------KVVDVEPEEYAVVAQDTIIHWEGEPINREDEENNMN---EVGYDDIGGCRKQM 223

  Fly   228 NSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREPK----IVNGP 288
            ..| |......:..|:|.:.:|.|..:|:|:|||||||||||||.:     |.|..    ::|||
Yeast   224 AQI-REMVELPLRHPQLFKAIGIKPPRGVLMYGPPGTGKTLMARAV-----ANETGAFFFLINGP 282

  Fly   289 QILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQ 353
            :::.|..||||:|:|:.|.|||:....        ||..||||:|..:|...  |..|...||:|
Yeast   283 EVMSKMAGESESNLRKAFEEAEKNAPA--------IIFIDEIDSIAPKRDKT--NGEVERRVVSQ 337

  Fly   354 LLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFN 418
            |||.:||:...:|::||..|||.:.||.||.|.||.:.:::|.:|:..||:::|.||||.|
Yeast   338 LLTLMDGMKARSNVVVIAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEVLRIHTKNM---- 398

  Fly   419 KINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNR---LIKADAKVTVDPEAMEKLKVNRDDF 480
            |:.||||.:.:||.|..:.||::..|...|....:..   ||..| :..:|.|.::.|.|..|:|
Yeast   399 KLADDVDLEALAAETHGYVGADIASLCSEAAMQQIREKMDLIDLD-EDEIDAEVLDSLGVTMDNF 462

  Fly   481 LHSLEHDIKPAFGTAQEILDNMLARGVINWG---------APVSNLLEDGMLYVQQAKAPESSGL 536
            ..:|.:....|      :.:.::....:.|.         ..:...:|..:|:..|......|..
Yeast   463 RFALGNSNPSA------LRETVVESVNVTWDDVGGLDEIKEELKETVEYPVLHPDQYTKFGLSPS 521

  Fly   537 VSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDM-VGYTESAKCLHIRKIFDDAYRSMLSCI 600
            ..||..|.|.:|||.||..:|......|:.|..||.: :.|.||..  :||.|||.|..:..:.:
Yeast   522 KGVLFYGPPGTGKTLLAKAVATEVSANFISVKGPELLSMWYGESES--NIRDIFDKARAAAPTVV 584

  Fly   601 VVDNVERLLDY--GSIGPR--YSNMTLQALLVLLKKQPPKGRKLLILCTSSRREVLEEMEMLTAF 661
            .:|.::.:...  ||:|..  .|:..:..||..:.....|....:|..|:...::...:......
Yeast   585 FLDELDSIAKARGGSLGDAGGASDRVVNQLLTEMDGMNAKKNVFVIGATNRPDQIDPAILRPGRL 649

  Fly   662 TSVLHVPNLSKPDH------VLAVLENTDIFSKGEIQAIGKKMAGKRVFIGIKKLLGLIDMARQT 720
            ..:::||   .||.      :.|.|..|.:....|:.||.|...|   |.| ..||.::
Yeast   650 DQLIYVP---LPDENARLSILNAQLRKTPLEPGLELTAIAKATQG---FSG-ADLLYIV------ 701

  Fly   721 EQSQRAIKFLSK 732
               |||.|:..|
Yeast   702 ---QRAAKYAIK 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011
		SpoVK	242..699	CDD:223540	148/483 (31%)
		AAA	256..397	CDD:278434	62/144 (43%)
		AAA	539..668	CDD:278434	33/133 (25%)
CDC48	NP_010157.1	CDC48	48..785	CDD:273521	175/597 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810