Protein Alignment comt and RIX7

DIOPT Version :10

• Sequence 1: NP_524877.1
• Gene: comt / 47091
• FlyBaseID: FBgn0000346
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_013066.1
• Gene: RIX7 / 850625
• SGDID: S000003957
• Length: 837
• Species: Saccharomyces cerevisiae
• Alignment Length: 821
• Identity: 193/821 - (23%)
• Similarity: 319/821 - (38%)
• Gaps: 237/821 - (28%)

  Fly     8 TKCPTDELSLTNRAIVNVGDFPEEIKYADISPAPGQHFIFALEKTVEVPSGYVGFSLVQRKWAMV 72
            |.|.|.:|||            :.:|...:.....:.....:|..:|....|.|:
Yeast    75 TFCLTKDLSL------------QRVKKVVLQKTIDRMLKDVIESELEEFGSYPGY---------- 117

  Fly    73 SINQELEVRPYRFDASSDVITCVSFETDFLQKKTVSQEPYDSDQMAKEFIMQFAGMALTVGQSLV 137
              |.|.|.:|             |.|.:..:|..:.:.  |:::|.|.....::... :|.:|:.
Yeast   118 --NNEEEEKP-------------SLEEELAKKNMMIER--DTNEMNKRITSTWSKSG-SVSESIT 164

  Fly   138 FNFKDKKLLGLAVKSLEAIDPKSLGEGKDTAMRNVRFGRILGNTVVQFEKAE------NSSLNLQ 196
                            |..|||: .|.|.:..|:..     |...|:.:|.:      ||||.
Yeast   165 ----------------ETDDPKT-EEVKKSKKRSKE-----GTCKVKRQKIKEDRSPPNSSLK-- 205

  Fly   197 GKSKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGP 261
                                  .:||:|.....:. ......:..||:....|.:..:|:||:||
Yeast   206 ----------------------SLGGMDDVVAQLM-ELIGLPILHPEIFLSTGVEPPRGVLLHGP 247

  Fly   262 PGTGKTLMARQIGTMLNAREPKI-VNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHII 325
            ||.|||.:|..:...|..  |.| ::.|.::....||||..:|.||.||    :.|.|    .::
Yeast   248 PGCGKTSIANALAGELQV--PFISISAPSVVSGMSGESEKKIRDLFDEA----RSLAP----CLV 302

  Fly   326 IFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKID--GVDQLNN--ILVIGMTNRRDMIDEALLRP 386
            .|||||||..:|...|... :...:|.||||.:|  .:::.|.  :::||.|||.|.:|.||.|.
Yeast   303 FFDEIDAITPKRDGGAQRE-MERRIVAQLLTSMDELTMEKTNGKPVIIIGATNRPDSLDAALRRA 366

  Fly   387 GRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSS 451
            ||.:.::.:::|||..|:.||    |:|.:..||:..:|..::|.||..|.||:|:.||.||.:.
Yeast   367 GRFDREICLNVPNEVSRLHIL----KKMSDNLKIDGAIDFAKLAKLTPGFVGADLKALVTAAGTC 427

  Fly   452 AMNRLIKADAKV---------------------------------TVDP---------------- 467
            |:.|:.:..|.:                                 .:||
Yeast   428 AIKRIFQTYANIKSTPTTATDSSEDNMEIDETANGDESSLKNTANMIDPLPLSVVQQFIRNYPEP 492

  Fly   468 ---EAMEKLKVNRDDFLHSLEHDIKP-----AFGTAQEILDNMLARGVINW---GAPVSNLLEDG 521
               |.:..|.:..:|||.:|. .|:|     .|.|..:          :.|   ||.....||..
Yeast   493 LSGEQLSLLSIKYEDFLKALP-TIQPTAKREGFATVPD----------VTWANVGALQRVRLELN 546

  Fly   522 MLYVQQAKAPE------SSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPE---DMVGYT 577
            |..||..|.||      .|....||:.|.|..|||.||..:|..|...|:.:..||   ..||.:
Yeast   547 MAIVQPIKRPELYEKVGISAPGGVLLWGPPGCGKTLLAKAVANESRANFISIKGPELLNKYVGES 611

  Fly   578 ESAKCLHIRKIFDDAYRSMLSCIVVDNVERLLDYGSIGPR-------YSNMTLQALLVLLKKQPP 635
            |.:    ||::|..|..|:...|..|.::.|:      ||       .|:..:..||..|.....
Yeast   612 ERS----IRQVFTRARASVPCVIFFDELDALV------PRRDTSLSESSSRVVNTLLTELDGLND 666

  Fly   636 KGRKLLILCTSSRREVL----------------------EEMEMLTAFTSVLHVPNLSKPDHVLA 678
            : |.:.::..::|.:::                      |:::::...|.....|..|..|....
Yeast   667 R-RGIFVIGATNRPDMIDPAMLRPGRLDKSLFIELPNTEEKLDIIKTLTKSHGTPLSSDVDFEEI 730

  Fly   679 VL-ENTDIFSKGEIQAIGKK---MAGKRVFIGIKKLLGLID 715
            :. |..:.||..::.|:.::   :|.||.|...:::..::|
Yeast   731 IRNEKCNNFSGADLAALVRESSVLALKRKFFQSEEIQSVLD 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_524877.1	CDC48_N	5..83	CDD:215012	14/74 (19%)
		CDC48_2	111..>158	CDD:215011	6/46 (13%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	60/180 (33%)
		CDC48	<220..>606	CDD:273521	133/459 (29%)
		SpoVK	<526..702	CDD:440232	48/217 (22%)
RIX7	NP_013066.1	CDC48	<192..824	CDD:273521	161/642 (25%)