DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and ATAD1

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001308896.1	Gene:	ATAD1 / 84896	HGNCID:	25903	Length:	361	Species:	Homo sapiens

Alignment Length:	376	Identity:	97/376 - (25%)
Similarity:	163/376 - (43%)	Gaps:	98/376 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LEAIDP--KSLGEGKDTAMRNVRFGRILGNTVVQFEKAENSSLNLQGKSKGKVVRQSIINP---- 211
            ::||||  |...|.:..|.:.:   :.:|...|:..:.|.|            :...:::|
Human    38 VDAIDPTRKQKVEAQKQAEKLM---KQIGVKNVKLSEYEMS------------IAAHLVDPLNMH 87

  Fly   212 -DWDFGKMGIGGLDKEFNS-------------IFRRAFASRVFPPELVEQLGCKHVKGILLYGPP 262
             .|.    .|.|||.....             :|..   ||:..|.          ||:||||||
Human    88 VTWS----DIAGLDDVITDLKDTVILPIKKKHLFEN---SRLLQPP----------KGVLLYGPP 135

  Fly   263 GTGKTLMARQIGTMLNAREP--KIVN-GPQIL-DKYVGESEANVRRLFAEAEEEEKRLGPNSGLH 323
            |.||||:|:     ..|:|.  :.:| .|..| ||:.|||:.....:|:.|    .:|.|:
Human   136 GCGKTLIAK-----ATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLA----IKLQPS---- 187

  Fly   324 IIIFDEIDAICKQRGSVAGNSGVHDTVV---NQLLTKIDGVDQLNN--ILVIGMTNRRDMIDEAL 383
            ||..||||:..:.|     :|..|:...   .|.::..||:|..::  ::|:|.|||...:|.|:
Human   188 IIFIDEIDSFLRNR-----SSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAI 247

  Fly   384 LRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAA 448
            :|  |:..:..|:.|..:.|..||.:..|.    ..::..||..|:|..|..|||::|:.:.|.|
Human   248 MR--RMPTRFHINQPALKQREAILKLILKN----ENVDRHVDLLEVAQETDGFSGSDLKEMCRDA 306

  Fly   449 QSSAMNRLIKADAKVTVDPE------------AMEKLKVNRD-DFLHSLEH 486
            ....:...:.:.::.:.|.:            |:||:|.::| .|.:.|.|
Human   307 ALLCVREYVNSTSEESHDEDEIRPVQQQDLHRAIEKMKKSKDAAFQNVLTH 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	2/4 (50%)
		SpoVK	242..699	CDD:223540	77/267 (29%)
		AAA	256..397	CDD:278434	49/149 (33%)
		AAA	539..668	CDD:278434
ATAD1	NP_001308896.1	RecA-like_ATAD1	92..257	CDD:410928	58/197 (29%)
ATAD1	NP_001308896.1	AAA_lid_3	282..321	CDD:407720	11/38 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810