DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and NSF

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_192400.2	Gene:	NSF / 825830	AraportID:	AT4G04910	Length:	742	Species:	Arabidopsis thaliana

Alignment Length:	739	Identity:	314/739 - (42%)
Similarity:	462/739 - (62%)	Gaps:	52/739 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKATKCPTDELSLTNRAIVNVGDFPE------EIKYADISPAPGQHFIFALEKTVEVPSGYVGFS 63
            :..|..|:.:|:.||.|..:..|..:      ::..|:::.:    ||.:|.....:..|.:..:
plant    12 MTVTNTPSADLAFTNLAYCSSSDLRQFSVPGSDLFLANVADS----FILSLCGHGSIRDGNIALN 72

  Fly    64 LVQRKWAMVSINQELEVR----PYRFDASSDVITCVSFETDFLQKKTVSQEPYDSDQMAKEFIMQ 124
            .:||:.|.||....:.|.    |..||     :..::.|.:|::|.|.| |..|:..::.:...:
plant    73 AIQRRHARVSTGDMVSVSRFVPPENFD-----LAMLTLELEFVKKGTKS-EQVDAALLSTQLKRK 131

  Fly   125 FAGMALTVGQSLVFNFKDKKLLGLAVKSLEAIDPKSLGEGKDTAMRNVRFGRILGNTVVQFEKAE 189
            :....|||||...|.:.....: |.|...:.       ||:|.. ..:..|.:..:|.:.||.:.
plant   132 YTNQVLTVGQKATFEYHGTNYI-LTVNRADV-------EGQDHT-NGIERGLLSKDTYIVFEASN 187

  Fly   190 NSSLNLQGKSKGKVVRQS-------IINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQ 247
            .|.:        |:|.|.       ..:.:::...:|||||..||..|||||||||||||.:..:
plant   188 ASGI--------KIVNQREAASSNIFKHKEFNLESLGIGGLGAEFADIFRRAFASRVFPPHVTSR 244

  Fly   248 LGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEE 312
            ||.|||||:||:|||||||||||||||.|||.::|||||||::|.|:|||:|.|||.|||:||::
plant   245 LGIKHVKGMLLFGPPGTGKTLMARQIGKMLNGKDPKIVNGPEVLSKFVGETEKNVRDLFADAEQD 309

  Fly   313 EKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRD 377
            ::.||..|.||:|||||||||||.|||....:||||::|||||||||||:.|||:|:||||||:|
plant   310 QRTLGDASELHVIIFDEIDAICKSRGSTRDGTGVHDSIVNQLLTKIDGVEALNNVLLIGMTNRKD 374

  Fly   378 MIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELE 442
            ::|||||||||||||:|||||:|.||:|||.|||.:|:|.:.:..|::.:|:||.|||:||||||
plant   375 LLDEALLRPGRLEVQVEISLPDEAGRLQILQIHTNKMKENSFLGTDINLQELAARTKNYSGAELE 439

  Fly   443 GLVRAAQSSAMNRLIKADAKVTVDPEAMEKLKVNRDDFLHSLEHDIKPAFGTAQEILDNMLARGV 507
            |:|::|.|.|:||.:..|.  ...|...|.:|:..:||||:: ::::||||.:.:.|:.....|:
plant   440 GVVKSATSYALNRQLSMDD--LTKPVEEENIKITMEDFLHAI-YEVQPAFGASTDDLERCRLNGM 501

  Fly   508 INWGAPVSNLLEDGMLYVQQAKAPESSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPED 572
            ::.|...:::.:..||.|:|.|....|.||:.|:.|...||||||||.:...||||:||:.|.|.
plant   502 VDCGHRHNHIYKRAMLLVEQVKVSTRSPLVTCLLEGPSGSGKTALAATIGIDSDFPYVKIVSAET 566

  Fly   573 MVGYTESAKCLHIRKIFDDAYRSMLSCIVVDNVERLLDYGSIGPRYSNMTLQALLVLLKKQPPKG 637
            |:|.:||.||.||.|:|:|||:|.:|.|::|::||||::.:||||:||:..|.|:||||:.||||
plant   567 MIGLSESTKCAHIVKVFEDAYKSPMSIIILDDIERLLEFIAIGPRFSNIISQTLMVLLKRLPPKG 631

  Fly   638 RKLLILCTSSRREVLEEMEMLTAFTSVLHVPNLSKPDHVLAVLENTDIFSKGEIQAIGKKMAGKR 702
            :|||:..|:|....||.:.:...|:....||.|.|.| ...||...::||:.::.:..:.:..
plant   632 KKLLVFGTTSEVTFLESVGISDCFSVTHSVPTLQKED-AKKVLNQLNLFSEDDVDSAAEALND-- 693

  Fly   703 VFIGIKKLLGLIDMARQTEQSQRA 726
              :.|||:..||:||.|.|....|
plant   694 --MPIKKIYMLIEMAAQGENGGSA 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012	18/87 (21%)
		CDC48_2	111..>158	CDD:215011	9/46 (20%)
		SpoVK	242..699	CDD:223540	238/456 (52%)
		AAA	256..397	CDD:278434	101/140 (72%)
		AAA	539..668	CDD:278434	63/128 (49%)
NSF	NP_192400.2	CDC48_N	12..92	CDD:215012	18/83 (22%)
		CDC48_2	127..173	CDD:281000	11/54 (20%)
		Parvo_NS1	170..>270	CDD:305166	49/107 (46%)
		AAA	251..396	CDD:214640	105/144 (73%)
		AAA	253..394	CDD:278434	101/140 (72%)
		AAA	527..662	CDD:99707	66/134 (49%)
		AAA	532..656	CDD:214640	62/123 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	218	1.000	Domainoid score	I732
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	552	1.000	Inparanoid score	I255
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197562at2759
OrthoFinder	1	1.000	-	-		FOG0003053
OrthoInspector	1	1.000	-	-		otm2625
orthoMCL	1	0.900	-	-		OOG6_101440
Panther	1	1.100	-	-	LDO	PTHR23078
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2410
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830