DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and IQCA1

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001257514.1	Gene:	IQCA1 / 79781	HGNCID:	26195	Length:	830	Species:	Homo sapiens

Alignment Length:	427	Identity:	90/427 - (21%)
Similarity:	152/427 - (35%)	Gaps:	120/427 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 RDMIDEALLRPGRLEVQMEISLP-NEQGRVQILNIHTKRMREFN---KINDDVDNKEIAALTKNF 436
            :|...|.:....|.|:|.||.:. :|..|.::.|:.....||..   |.....|.|      |..
Human   424 QDYDPELIKEEKRKELQSEIRIQVDELMRQELKNLKLAVDRERERPVKAGKKKDKK------KGK 482

  Fly   437 SGAELEGLVRAAQSSAMNRLIKADAKVTVDPEAM-EKLKVNRDDFLHSLEHDIKPAFGTAQEILD 500
            .|.:.|...:..:....:|.|::..|..|:...: :.||||..|::....:            |.
Human   483 KGKKKEKKAKKDKDLTADRTIESLYKELVEEGLLIQALKVNLSDYIGEYSY------------LG 535

  Fly   501 NMLARGVINWGAPVSNLLE-------DGMLYVQQAKAPESSGLV-SVLVAGAPNSGK-------- 549
            ..|.:..|.   |:.:||:       .|:..:..|...|.:.|| |:|:||....||
Human   536 TTLRQVSIE---PMPSLLDVRQLITLYGIWPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAIC 597

  Fly   550 TALAAQLAKMSD------FPFVKVCSPEDMVGYTESAKCLHIRKIFDDAYRSMLSCIVVDNVERL 608
            |...|.|..:|.      :|           |.......||  .:|..|.:...|.:.:::.|:.
Human   598 TETGANLFNLSSSNIAGKYP-----------GKNGLQMMLH--AVFKVARQLQPSVVWIEDTEKT 649

  Fly   609 LDYGSI-------GPRYSNMTLQALLVLLKKQPPKGRKLLILCTSSRREVLEEMEMLTAFTSVLH 666
            . |..:       .|:.....|..:|.|||   |..| :||:.|:.|....|.......:..::.
Human   650 F-YKKVPNAEKMNEPKRLKKHLPQILKLLK---PDDR-ILIVGTTRRPFDAELQSFCKVYQKIIL 709

  Fly   667 VPNLSKPDH-----------------------VLAVLENTDIFSKGEIQAIGKKMAGKRVFIGIK 708
            ||   :||:                       |..:.:.||.|::|.|..:            :|
Human   710 VP---RPDYASRYVLWKQIIERNGGVLTSALNVSCLAKVTDGFTQGHIVEV------------VK 759

  Fly   709 KLLGLIDMARQTEQSQRAIKFLS---------KMEEE 736
            .:|....:.||..:...|::|::         |.|||
Human   760 GVLTDQRIRRQIHKPLTAVEFITAITSMNPVYKEEEE 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011
		SpoVK	242..699	CDD:223540	80/379 (21%)
		AAA	256..397	CDD:278434	7/20 (35%)
		AAA	539..668	CDD:278434	31/149 (21%)
IQCA1	NP_001257514.1	SpoVK	<497..796	CDD:223540	70/346 (20%)
IQCA1	NP_001257514.1	AAA	579..712	CDD:278434	33/153 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900