DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and pex6

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_001332652.5	Gene:	pex6 / 792998	ZFINID:	ZDB-GENE-081104-252	Length:	1071	Species:	Danio rerio

Alignment Length:	456	Identity:	123/456 - (26%)
Similarity:	212/456 - (46%)	Gaps:	111/456 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 SQEPYDSDQMAKEFIMQFAGMALTVGQ--SLVFNFKDKKLLGLAVKSLEAIDPKSLGE-GKDTAM 169
            ||....||.|| .|:.|.|..:|:..|  .::.:..:..|||..|         :||. .|.||
Zfish   666 SQHELPSDVMA-AFVHQVAIESLSEDQRRMVLSSLSEDLLLGKDV---------NLGRIAKQTA- 719

  Fly   170 RNVRFGRILGNTVVQFEKAENSSLNLQGKSKGKVVRQSII----------NPDWDFGKMGIGGLD 224
                 |.:||:.......|            ||...:.::          ..:.|....|:....
Zfish   720 -----GFVLGDLCALLTNA------------GKAAHRRLVETYFPEAVSEQEEEDLCVSGVSVTS 767

  Fly   225 KEFNS---IFRRAFASRVFPP------------------ELVE--QLGCKHVK---------GIL 257
            ::|::   :.:.|.:..:..|                  |:::  ||..:|.:         |:|
Zfish   768 EDFSAALDVLQEAHSQAIGAPKIPAVSWQDVGGLQQVKKEILDTIQLPLEHPELLSLGLRRSGLL 832

  Fly   258 LYGPPGTGKTLMARQIG-----TMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLG 317
            |||||||||||:|:.:.     |.|:      |.||::::.|||:||.|:|::.::|.
Zfish   833 LYGPPGTGKTLLAKAVATECTMTFLS------VKGPELINMYVGQSEENIRQVSSKAR------- 884

  Fly   318 PNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEA 382
             ::...||.|||:|::...||....:.||.|.||:|||.::||:....::.|||.|||.|::|::
Zfish   885 -SAAPCIIFFDELDSLAPNRGHSGDSGGVMDRVVSQLLAELDGLHSSGDVFVIGATNRPDLLDQS 948

  Fly   383 LLRPGRLEVQMEISLPNE--QGRVQILNIHTKRMREFNKINDDVDNKEIA-ALTKNFSGAELEGL 444
            ||||||.:..:.:.: ||  :.::|:|.   ..:|:| |::..|...:|. :.....:||:|..|
Zfish   949 LLRPGRFDKLVYVGI-NEDRESQLQVLK---AILRKF-KVDASVCLSDIVESCPPRLTGADLYSL 1008

  Fly   445 VRAAQSSAMNRLIKADAKVT--VDPEAMEKLKVNRDDFLHSLEHDIKPAFGTAQ----EILDNML 503
            ...|...|:.|.|   :::|  ||.| :..|.:..:||..:|. .::|:....|    ::|...|
Zfish  1009 CSDAMMCAVKRKI---SRITEGVDSE-LSSLTLCSEDFSEALS-GLQPSVSEQQISRYQLLQQKL 1068

  Fly   504 A 504
            :
Zfish  1069 S 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	13/48 (27%)
		SpoVK	242..699	CDD:223540	93/306 (30%)
		AAA	256..397	CDD:278434	58/145 (40%)
		AAA	539..668	CDD:278434
pex6	XP_001332652.5	SpoVK	561..1060	CDD:223540	121/445 (27%)
		P-loop_NTPase	562..>620	CDD:304359
		AAA	834..962	CDD:278434	56/141 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900