DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and nsf

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_012808037.1	Gene:	nsf / 780249	XenbaseID:	XB-GENE-5936011	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	733	Identity:	453/733 - (61%)
Similarity:	577/733 - (78%)	Gaps:	3/733 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKATKCPTDELSLTNRAIVNVGDFPEEIKYADISPAPGQHFIFALEKTVEVPSGYVGFSLVQRKW 69
            ::|.:|||||||:||.|:||..|| :..::.::..:|...:||.::....:..|.:.|||.||||
Frog     6 MQAARCPTDELSITNCAVVNEKDF-QSGQHVNVRTSPNHRYIFTVKTHHTILPGSIAFSLPQRKW 69

  Fly    70 AMVSINQELEVRPYRFDASSDVITCVSFETDFLQKKTVSQEPYDSDQMAKEFIMQFAGMALTVGQ 134
            |.:||.|::||..|.||.:...|..::.|.||||||::...|||:|:||.|||.||...|.:|||
Frog    70 AGLSIGQDVEVGVYTFDKTKQCIGTMTIEIDFLQKKSIDSNPYDTDRMAAEFIQQFNNQAFSVGQ 134

  Fly   135 SLVFNFKDKKLLGLAVKSLEAIDPKSL-GEGKDTAMRNVRFGRILGNTVVQFEKAENSSLNLQGK 198
            .|||:|.| ||.||.||.:||:||..| ||......:.:..|.::||:.|.||||::|||||.||
Frog   135 QLVFSFND-KLFGLVVKDIEAMDPSILKGEQSTGKRQKIEVGLVVGNSQVVFEKADSSSLNLTGK 198

  Fly   199 SKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPG 263
            ||.:..|||||||||:|.|||||||||||:.||||||||||||||:|||:||||||||||:||||
Frog   199 SKTRQDRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLFGPPG 263

  Fly   264 TGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFD 328
            .||||||||||.||||||||:||||:||:|||||||||:|:|||:||||::|||.||||||||||
Frog   264 CGKTLMARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFD 328

  Fly   329 EIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQM 393
            |||||||||||:||::|||||||||||:|||||:|||||||||||||.|:|||||||||||||:|
Frog   329 EIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKM 393

  Fly   394 EISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNRLIK 458
            ||.||:|:||:|||:|||.||||.:.::.|||..|:|..||||||||||||||||||:||||.||
Frog   394 EIGLPDEKGRLQILHIHTARMREHSLLSSDVDVGELAQETKNFSGAELEGLVRAAQSTAMNRHIK 458

  Fly   459 ADAKVTVDPEAMEKLKVNRDDFLHSLEHDIKPAFGTAQEILDNMLARGVINWGAPVSNLLEDGML 523
            |..||.||.|..|:|:|.:.||..||.:||||||||.||...:.:..|:|.||.||:.:|:||.|
Frog   459 ATNKVEVDMEKAERLQVTKGDFFTSLGNDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGEL 523

  Fly   524 YVQQAKAPESSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDMVGYTESAKCLHIRKI 588
            .|||.|..:.:.|||||:.|.|:||||||||::::.|:|||:|:||||.|:|::|:|||..|:||
Frog   524 LVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKISEESNFPFIKICSPEKMIGFSETAKCQAIKKI 588

  Fly   589 FDDAYRSMLSCIVVDNVERLLDYGSIGPRYSNMTLQALLVLLKKQPPKGRKLLILCTSSRREVLE 653
            |:|||:|.|||:|||::||||||..||||:||:.||||||||||.||:||||||:.|:||::||:
Frog   589 FEDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQ 653

  Fly   654 EMEMLTAFTSVLHVPNLSKPDHVLAVLENTDIFSKGEIQAIGKKMAGKRVFIGIKKLLGLIDMAR 718
            |||||.||::.:.|||:...:.::..||....|...|...|.:::.||:|:|||||||.||:|:.
Frog   654 EMEMLDAFSTTIRVPNIVTGEQLMEALELLGGFKDNERSVIAQQVKGKKVYIGIKKLLMLIEMSM 718

  Fly   719 QTEQSQRAIKFLSKMEEE 736
            |.:...|..|||:.::||
Frog   719 QMDPEYRVSKFLALLKEE 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012	32/77 (42%)
		CDC48_2	111..>158	CDD:215011	28/46 (61%)
		SpoVK	242..699	CDD:223540	307/456 (67%)
		AAA	256..397	CDD:278434	120/140 (86%)
		AAA	539..668	CDD:278434	83/128 (65%)
nsf	XP_012808037.1	CDC48_N	5..84	CDD:376770	32/78 (41%)
		CDC48_2	111..183	CDD:215011	36/72 (50%)
		CDC48	<211..>606	CDD:273521	284/394 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I2110
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4502
Inparanoid	1	1.050	892	1.000	Inparanoid score	I385
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D156590at33208
OrthoFinder	1	1.000	-	-		FOG0003053
OrthoInspector	1	1.000	-	-		otm48046
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1308
SonicParanoid	1	1.000	-	-		X2410
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.090