DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and spata5l1

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001070056.2	Gene:	spata5l1 / 767648	ZFINID:	ZDB-GENE-060929-204	Length:	748	Species:	Danio rerio

Alignment Length:	749	Identity:	187/749 - (24%)
Similarity:	292/749 - (38%)	Gaps:	213/749 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ITCVSFETDFLQ----KKTVS----QEPYDSDQMAKEFIMQFAGMALTVGQSLVFNFKDKKLLGL 148
            :|||..:. |:|    ||.||    ||..|...:.:..::..:|:...:...||
Zfish    95 LTCVKLKV-FVQRLEHKKRVSERSLQELLDGIYVHEGHLVDLSGVKAEIRCVLV----------- 147

  Fly   149 AVKSLEAIDPKSLGEGKDTAMRNVRFGRILGNTVVQFEKAENSSLNLQGKSKGKVVRQSIINPDW 213
                 |.::..|...|..||...|....|  .||...::.:               :|....|
Zfish   148 -----EKVNSGSQRAGLITARTCVDISTI--QTVKHLDRQQ---------------QQVSAAP-- 188

  Fly   214 DFGKMGIGGLDKEFNSIFRRAFASRVFP---PELVEQLGCKHVKGILLYGPPGTGKTLM----AR 271
                  :||::..|.|:....    .||   |..:.|||....:|:||.||||.||||:    |:
Zfish   189 ------LGGMEDVFASLKEMI----TFPLRYPGSLRQLGLSCPRGLLLIGPPGVGKTLLVRCVAK 243

  Fly   272 QIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQ 336
            .||..|     ..||||::.....||||.|:||:|     |:.|...:.|..:::.||||::|.:
Zfish   244 DIGATL-----VTVNGPEVTGSRPGESEENLRRVF-----EQARDAADDGPCVLLIDEIDSLCPR 298

  Fly   337 RGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQ 401
            |  ...:|...:.:|.||||.:|.:......::||.||:.|.:|.||.||||.:.::.|.:|:..
Zfish   299 R--TGSSSAPENRLVAQLLTLMDAIGSHEGFVIIGATNQPDSLDPALRRPGRFDREVIIGVPSLL 361

  Fly   402 GRVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNRLIKADAKVTVD 466
            .|..||....:.|    .::.|||...:|.:|..:.||:|..|.|.|...|| |..:..|.   :
Zfish   362 QRRSILKCVCREM----PLSPDVDLNTLAEMTCGYVGADLSALSREAALQAM-RHSQMGAS---E 418

  Fly   467 PEAMEKLKVNRDDFLHSLEH-------------DIKPAFGTAQEILDNMLARGVINW---GAPVS 515
            |.:|:       .|:.:|.|             |.||                 |.|   |.
Zfish   419 PVSMQ-------HFMQALRHVQPSCLRSSIGATDFKP-----------------IGWEQIGG--- 456

  Fly   516 NLLEDGMLYVQQA-----KAPES------SGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCS 569
              |||..|.::|:     :.||:      |....||:.|.|...||.|....|..|...|..:..
Zfish   457 --LEDVKLKLKQSIEWPMRFPEAFVRLGVSRPRGVLLYGPPGCAKTTLVKAAASSSHCSFFSLSG 519

  Fly   570 PEDMVGYT-ESAKCLHIRKIFDDAYRSMLSCIVVDNVERLLDYGSIGPRYS-NMTLQALLVLLKK 632
            .|....|. :|.|.|  .::|..|.....|.:.:|.|:.::.....|...| ::..|.|.|||.:
Zfish   520 AELFSPYVGDSEKTL--AQLFAQARACAPSIVFLDEVDSMVGSREDGSSSSHSVQSQVLSVLLTE 582

  Fly   633 QPPKG----------RKLLILCTSSRREV-LEEMEM----------------------------- 657
            ....|          ||:.:|....:.:| |.:||:
Zfish   583 LDGVGVRTLERRSTCRKIALLEGGDQEDVRLHQMELQEVCNKDVLIVAATNRPEALDSALLRPGR 647

  Fly   658 -----------LTAFTSVLHVPNLSKPDHVLAVLEN----TDIFSKGEIQAIGKKMA-------- 699
                       |.|..:||.:...|.|.|....||:    |::||..:::.:.|:.|
Zfish   648 LDQIIYVPPPDLQARLAVLRICTKSVPLHQDVCLEDLAAQTELFSGADLENLCKEAALLALREDG 712

  Fly   700 ------GKRVFIGIKKLLGLIDMARQTEQSQRAI 727
                  .::.|:   |.|.::..:...||.|:.|
Zfish   713 LAVSCVRQKYFL---KALQMLSPSLSAEQLQQNI 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	5/46 (11%)
		SpoVK	242..699	CDD:223540	147/544 (27%)
		AAA	256..397	CDD:278434	55/144 (38%)
		AAA	539..668	CDD:278434	39/181 (22%)
spata5l1	NP_001070056.2	CDC48	13..740	CDD:273521	185/744 (25%)
		AAA	224..357	CDD:278434	55/144 (38%)
		AAA	489..655	CDD:278434	35/167 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900