DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and Iqca

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001355651.1	Gene:	Iqca / 74918	MGIID:	1922168	Length:	838	Species:	Mus musculus

Alignment Length:	703	Identity:	142/703 - (20%)
Similarity:	252/703 - (35%)	Gaps:	207/703 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 KDKKLLG--LAVKSLEAIDPKSLGEGKDTAMRNVR----------------FGRILGNTVVQFEK 187
            |:.||||  |....|.|:..:.:..|.....:.|:                |..: .:.:||.::
Mouse   194 KEMKLLGHRLLDTKLAALQIQKVWRGFHQCKKTVKEREEEMVFLGMKPSPLFNEV-SDAIVQSKQ 257

  Fly   188 AENSSLNLQGKSKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAF-----ASRVFPPELVEQ 247
            ..|....:|.|.: :..:::::|...|...:....:.:......|:.|     .:..||....|:
Mouse   258 VTNLRDEVQLKHE-QDYQEALVNIKEDLKMLEGPDIKEHLQDQIRQWFIECRNLTGTFPDYPNEE 321

  Fly   248 LGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILD------------KYVGESEA 300
            .|     |..|.....|.:.:|...|.|  ...|.|:....:..|            |...|.:.
Mouse   322 DG-----GSALIFSNKTPEQVMGDIIAT--QEEEEKLKKKKKKEDKENKGKKGKKEKKEKKEKKV 379

  Fly   301 NVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLN 365
            :::....:.|:||.::.|:  |.:.:.:|            |||...|..:|:        |:..
Mouse   380 SLKEKAMKDEDEEWKMSPS--LFLQLMEE------------GNSLYKDIWLNK--------DESW 422

  Fly   366 NILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFN-KINDDVD---- 425
            |.       .:|...|.:....|.|::|||       |||:..:..:.::... .:|.:::
Mouse   423 NF-------PQDYDPELIKEEKRKELEMEI-------RVQVDELMRQELKNLKLAVNREMEIPPR 473

  Fly   426 NKEIAALTKNFSGAELEGLVRAAQSSAMNRLIKADAKV-TVDPEAMEK------LKVNRDDFLHS 483
            .|:.....|...|       |..:.....:.:.||..: ::..|.:||      ||||..|::..
Mouse   474 QKKGKKKNKGRKG-------RRGKRGKKEKDLTADRTIESLYQELVEKGLLIQALKVNLSDYIGE 531

  Fly   484 LEHDIKPAFGTAQEILDNMLARGVINWGAPVSNLLE-------DGMLYVQQAKAPESSGLV-SVL 540
            ..:            |...|.:..|.   |:.:||:       .|:|.:..|:..|.:.|| |:|
Mouse   532 YSY------------LGTTLRQVAIE---PMPSLLDVRQLITLYGILPLGSAEVHERAPLVKSLL 581

  Fly   541 VAGAPNSGK--------TALAAQLAKMS------DFPFVKVCSPEDMVGYTESAKCLHIRKIFDD 591
            :||....||        |...|.|..:|      .:|           |.|.....:|:  :|..
Mouse   582 LAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYP-----------GKTGLQMMIHL--VFKV 633

  Fly   592 AYRSMLSCIVVDNVERLLDYGSI-------GPRYSNMTLQALLVLLKKQPPKGRKLLILCTSSRR 649
            |.:...|.:.:.:.|:.. |..:       .|:.....|..||.|||   |..| :||:.|:.|.
Mouse   634 ARQLQPSVVWIQDTEKTF-YKKVPQAEKRFEPKRLKRYLPKLLKLLK---PDDR-ILIVGTTHRP 693

  Fly   650 EVLEEMEMLTAFTSVLHVPNLSKPD----HVL---AVLEN----------------TDIFSKGEI 691
            ...|.......:..::.||   :||    :||   .:|.|                ||.|::|:|
Mouse   694 FDAELQPFCRVYQKIILVP---RPDYASRYVLWKEIILRNGGKLTNSLNISCLSKVTDGFTQGQI 755

  Fly   692 QAIGKKMAGKRVFIGIKKLLGLIDMARQTEQSQRAIKFLSKM--------EEE 736
            ..:            ||.:|....:.:|..:...||:|::.|        |||
Mouse   756 VQV------------IKDVLTERRLRQQAHKPLTAIEFITMMTNMNPVYREEE 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	8/18 (44%)
		SpoVK	242..699	CDD:223540	109/532 (20%)
		AAA	256..397	CDD:278434	30/152 (20%)
		AAA	539..668	CDD:278434	32/149 (21%)
Iqca	NP_001355651.1	SpoVK	<578..797	CDD:223540	57/252 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900