DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and Pex1

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001280735.1	Gene:	Pex1 / 71382	MGIID:	1918632	Length:	1284	Species:	Mus musculus

Alignment Length:	503	Identity:	148/503 - (29%)
Similarity:	224/503 - (44%)	Gaps:	98/503 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 KKLLGLAVKSLEAIDPKSLGEGKDTAMRNVRFGRILGNTVVQFEKAENSSLNLQGKSKGK----- 202
            |..||..:.:...:|.:.:  .|||.....|      :..|..::|.:|||:.|..|..:
Mouse   755 KNKLGCDISNFPDLDLQCI--AKDTEAFVAR------DFTVLVDRAIHSSLSRQHSSSREDLTLT 811

  Fly   203 --------------VVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHV 253
                          .:|...::...|.|...|||| .|...|...........|||...|..:..
Mouse   812 TSDFQKALRGFLPASLRNVNLHKPRDLGWDKIGGL-HEVRQILMDTIQLPAKYPELFANLPIRQR 875

  Fly   254 KGILLYGPPGTGKTLMARQIGTMLNAREPKI----VNGPQILDKYVGESEANVRRLFAEAEEEEK 314
            .||||||||||||||:|..:     |||..:    :.||::|.||:|.||..||.:|..|:..:.
Mouse   876 TGILLYGPPGTGKTLLAGVV-----ARESGMNFISIKGPELLSKYIGASEQAVRDVFIRAQAAKP 935

  Fly   315 RLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMI 379
                    .|:.|||.::|..:||.  .|:||.|.|||||||::|||:.|..:.|:..|:|.|:|
Mouse   936 --------CILFFDEFESIAPRRGH--DNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLI 990

  Fly   380 DEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGL 444
            |.||||||||:..:....|::..|::||.:.:|.:    .:.||||.:.:|::|.:|:||:|:.|
Mouse   991 DPALLRPGRLDKCVYCPPPDQVSRLEILTVLSKSL----ALADDVDLQHVASVTDSFTGADLKAL 1051

  Fly   445 VRAAQSSAM-NRLIKA---DAKVTVDPEAMEKLKVNRDDFL-HSLEHDIKPA---FGTAQEILDN 501
            :..||..|: .||:.:   |...:.|.:    |.::...|| ||...|....   .|..|.:|
Mouse  1052 LYNAQLEALQGRLLPSGLPDGGSSSDSD----LSLSSMVFLNHSSGSDDSAGDGECGLEQSLL-- 1110

  Fly   502 MLARGVINWGAPVSNLLED-----------GMLYVQQAKAPESSGLVSVLVAGAPNSGKTALAAQ 555
                     ...:|.:|.|           |..|..:......|.|.|..:: ||:|....|.|.
Mouse  1111 ---------SLEMSEILPDESKFNMYRLYFGSSYESELGNGTPSDLSSHCLS-APSSVTQDLPAA 1165

  Fly   556 LAK---MSDFPFVKVCSPEDMVGYTESAKCLHIRKIFDDAYRSMLSCI 600
            ..|   .:..|..:..|.|.....|:..:         |..|:.:|.|
Mouse  1166 PGKDPLFTQHPVFRTPSQEGCQDLTQEQR---------DQLRAEISII 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	3/14 (21%)
		SpoVK	242..699	CDD:223540	124/385 (32%)
		AAA	256..397	CDD:278434	65/144 (45%)
		AAA	539..668	CDD:278434	14/65 (22%)
Pex1	NP_001280735.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..373
		AAA	592..742	CDD:214640
		AAA	596..725	CDD:278434
		AAA	878..1010	CDD:214640	65/146 (45%)
		AAA	878..1007	CDD:278434	65/143 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1261..1284
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810