Protein Alignment comt and Trip13

DIOPT Version :10

• Sequence 1: NP_524877.1
• Gene: comt / 47091
• FlyBaseID: FBgn0000346
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_081458.1
• Gene: Trip13 / 69716
• MGIID: 1916966
• Length: 432
• Species: Mus musculus
• Alignment Length: 482
• Identity: 92/482 - (19%)
• Similarity: 179/482 - (37%)
• Gaps: 116/482 - (24%)

  Fly    48 ALEKTVEVPSGYVGFSLVQRKWAMVSINQELEVRPYRFDASSDVI----TCVSFETDFLQKKTVS 108
            ||....|.|:.:|  .::||..:... .::::...||.....:::    ....|:..||.:...|
Mouse    11 ALPCVAESPAVHV--EVLQRSGSTAK-KEDIKSSVYRLLNRHNIVFGDYVWTEFDDPFLSRNVQS 72

  Fly   109 QEPYDSDQMAKEFIMQFAGMALTVGQSLVFNFKDKKLLGLAVKSLEAIDPKSLGEGKDTAMRNVR 173
            ....|::                                     |:|.||:.:.....|
Mouse    73 VSIVDTE-------------------------------------LKAKDPQPIDLSACT------ 94

  Fly   174 FGRILGNTVVQFEKAENSSLNLQGKSKGKVVRQSIINPDWDFGKMGIGGL------DKEFNS-IF 231
                :...:.|..:...||.||..:::..:.....:.|..:|     .||      |.|..| :.
Mouse    95 ----IALHIFQLNEEGPSSENLDEETENIIAASHWVLPAAEF-----HGLWDSLVYDVEVKSHLL 150

  Fly   232 RRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAR--------EPKIVNGP 288
            .....:.:|..:.|:.......:.:||:||||||||.:.:.:...|..|        :...:|..
Mouse   151 DYVMTTVLFSDKNVDSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSH 215

  Fly   289 QILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDT--VV 351
            .:..|:..||...|.::|.:.::   .:.....|..::.||::::...|.:....:...|.  ||
Mouse   216 SLFSKWFSESGKLVTKMFQKIQD---LIDDKEALVFVLIDEVESLTAARNACRAGAEPSDAIRVV 277

  Fly   352 NQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQG-------------- 402
            |.:||:||.:.:.:|::::..:|..:.||.|.:  .|.:::..|..|:...
Mouse   278 NAVLTQIDQIKRHSNVVILTTSNITEKIDVAFV--DRADIKQYIGPPSAAAIFKIYLSCLEELMK 340

  Fly   403 ------RVQILNIHTKRMREFNKINDDVDN-----KEIAALTKNFSGAEL-------EGLVRAAQ 449
                  |.|:|.:....|..|  |.::|..     .||:..::..||..|       ..|...|.
Mouse   341 CQIIYPRQQLLTLRELEMIGF--IENNVSKLSLLLSEISRKSEGLSGRVLRKLPFLAHALYIQAP 403

  Fly   450 SSAMNRLIKADAKVTVDPEAMEKLKVN 476
            |..:...::| ..:.||.:..||.|::
Mouse   404 SVTIEGFLQA-LSLAVDKQFEEKKKLS 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_524877.1	CDC48_N	5..83	CDD:215012	7/34 (21%)
		CDC48_2	111..>158	CDD:215011	3/46 (7%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	43/192 (22%)
		CDC48	<220..>606	CDD:273521	66/306 (22%)
		SpoVK	<526..702	CDD:440232
Trip13	NP_081458.1	McrB	34..>205	CDD:441011	38/223 (17%)
		RecA-like_Pch2-like	121..319	CDD:410916	45/207 (22%)