DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and Trip13

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_081458.1	Gene:	Trip13 / 69716	MGIID:	1916966	Length:	432	Species:	Mus musculus

Alignment Length:	482	Identity:	92/482 - (19%)
Similarity:	179/482 - (37%)	Gaps:	116/482 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ALEKTVEVPSGYVGFSLVQRKWAMVSINQELEVRPYRFDASSDVI----TCVSFETDFLQKKTVS 108
            ||....|.|:.:|  .::||..:... .::::...||.....:::    ....|:..||.:...|
Mouse    11 ALPCVAESPAVHV--EVLQRSGSTAK-KEDIKSSVYRLLNRHNIVFGDYVWTEFDDPFLSRNVQS 72

  Fly   109 QEPYDSDQMAKEFIMQFAGMALTVGQSLVFNFKDKKLLGLAVKSLEAIDPKSLGEGKDTAMRNVR 173
            ....|::                                     |:|.||:.:.....|
Mouse    73 VSIVDTE-------------------------------------LKAKDPQPIDLSACT------ 94

  Fly   174 FGRILGNTVVQFEKAENSSLNLQGKSKGKVVRQSIINPDWDFGKMGIGGL------DKEFNS-IF 231
                :...:.|..:...||.||..:::..:.....:.|..:|     .||      |.|..| :.
Mouse    95 ----IALHIFQLNEEGPSSENLDEETENIIAASHWVLPAAEF-----HGLWDSLVYDVEVKSHLL 150

  Fly   232 RRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAR--------EPKIVNGP 288
            .....:.:|..:.|:.......:.:||:||||||||.:.:.:...|..|        :...:|..
Mouse   151 DYVMTTVLFSDKNVDSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSH 215

  Fly   289 QILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDT--VV 351
            .:..|:..||...|.::|.:.::   .:.....|..::.||::::...|.:....:...|.  ||
Mouse   216 SLFSKWFSESGKLVTKMFQKIQD---LIDDKEALVFVLIDEVESLTAARNACRAGAEPSDAIRVV 277

  Fly   352 NQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQG-------------- 402
            |.:||:||.:.:.:|::::..:|..:.||.|.:  .|.:::..|..|:...
Mouse   278 NAVLTQIDQIKRHSNVVILTTSNITEKIDVAFV--DRADIKQYIGPPSAAAIFKIYLSCLEELMK 340

  Fly   403 ------RVQILNIHTKRMREFNKINDDVDN-----KEIAALTKNFSGAEL-------EGLVRAAQ 449
                  |.|:|.:....|..|  |.::|..     .||:..::..||..|       ..|...|.
Mouse   341 CQIIYPRQQLLTLRELEMIGF--IENNVSKLSLLLSEISRKSEGLSGRVLRKLPFLAHALYIQAP 403

  Fly   450 SSAMNRLIKADAKVTVDPEAMEKLKVN 476
            |..:...::| ..:.||.:..||.|::
Mouse   404 SVTIEGFLQA-LSLAVDKQFEEKKKLS 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012	7/34 (21%)
		CDC48_2	111..>158	CDD:215011	3/46 (7%)
		SpoVK	242..699	CDD:223540	60/277 (22%)
		AAA	256..397	CDD:278434	37/150 (25%)
		AAA	539..668	CDD:278434
Trip13	NP_081458.1	AAA	172..322	CDD:214640	37/154 (24%)
Trip13	NP_081458.1	AAA	175..320	CDD:278434	36/149 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810