DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and Nsf

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_068516.2	Gene:	Nsf / 60355	RGDID:	621594	Length:	744	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	463/734 - (63%)
Similarity:	576/734 - (78%)	Gaps:	3/734 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKATKCPTDELSLTNRAIVNVGDFPEEIKYADISPAPGQHFIFALEKTVEVPSGYVGFSLVQRKW 69
            ::|.:||||||||:|.|:||..|: :..::..:..:|...:||.|.....|..|.:.|||.||||
  Rat     6 MQAARCPTDELSLSNCAVVNEKDY-QSGQHVMVRTSPNHKYIFTLRTHPSVVPGCIAFSLPQRKW 69

  Fly    70 AMVSINQELEVRPYRFDASSDVITCVSFETDFLQKKTVSQEPYDSDQMAKEFIMQFAGMALTVGQ 134
            |.:||.|::||..|.||.:...|..::.|.||||||.:...|||:|:||.|||.||...|.:|||
  Rat    70 AGLSIGQDIEVALYSFDKAKQCIGTMTIEIDFLQKKNIDSNPYDTDKMAAEFIQQFNNQAFSVGQ 134

  Fly   135 SLVFNFKDKKLLGLAVKSLEAIDPKSL-GEGKDTAMRNVRFGRILGNTVVQFEKAENSSLNLQGK 198
            .|||:|.| ||.||.||.:||:||..| ||......:.:..|.::||:.|.|||||||||||.||
  Rat   135 QLVFSFND-KLFGLLVKDIEAMDPSILKGEPASGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGK 198

  Fly   199 SKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPG 263
            :|.|..|||||||||:|.|||||||||||:.||||||||||||||:|||:|||||||||||||||
  Rat   199 AKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPG 263

  Fly   264 TGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFD 328
            .||||:|||||.||||||||:||||:||:|||||||||:|:|||:||||::|||.||||||||||
  Rat   264 CGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFD 328

  Fly   329 EIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQM 393
            |||||||||||:||::|||||||||||:|||||:|||||||||||||.|:|||||||||||||:|
  Rat   329 EIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKM 393

  Fly   394 EISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNRLIK 458
            ||.||:|:||:|||:|||.|||....::.|||.||:|..||||||||||||||||||:||||.||
  Rat   394 EIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIK 458

  Fly   459 ADAKVTVDPEAMEKLKVNRDDFLHSLEHDIKPAFGTAQEILDNMLARGVINWGAPVSNLLEDGML 523
            |..||.||.|..|.|:|.|.|||.|||:||||||||.||...:.:..|:|.||.||:.:|:||.|
  Rat   459 ASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGEL 523

  Fly   524 YVQQAKAPESSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDMVGYTESAKCLHIRKI 588
            .|||.|..:.:.|||||:.|.|:||||||||::|:.|:|||:|:|||:.|:|::|:|||..::||
  Rat   524 LVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKI 588

  Fly   589 FDDAYRSMLSCIVVDNVERLLDYGSIGPRYSNMTLQALLVLLKKQPPKGRKLLILCTSSRREVLE 653
            |||||:|.|||:|||::||||||..||||:||:.||||||||||.||:||||||:.|:||::||:
  Rat   589 FDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQ 653

  Fly   654 EMEMLTAFTSVLHVPNLSKPDHVLAVLENTDIFSKGEIQAIGKKMAGKRVFIGIKKLLGLIDMAR 718
            |||||.||::.:||||::..:.:|..||....|...|...|.:::.||:|:|||||||.||:|:.
  Rat   654 EMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSL 718

  Fly   719 QTEQSQRAIKFLSKMEEEG 737
            |.:...|..|||:.|.|||
  Rat   719 QMDPEYRVRKFLALMREEG 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012	33/77 (43%)
		CDC48_2	111..>158	CDD:215011	28/46 (61%)
		SpoVK	242..699	CDD:223540	312/456 (68%)
		AAA	256..397	CDD:278434	120/140 (86%)
		AAA	539..668	CDD:278434	84/128 (66%)
Nsf	NP_068516.2	CDC48_N	6..83	CDD:215012	33/77 (43%)
		CDC48_2	111..183	CDD:215011	36/72 (50%)
		CDC48	159..>606	CDD:273521	315/446 (71%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	151/175 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341632
Domainoid	1	1.000	247	1.000	Domainoid score	I2084
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4502
Inparanoid	1	1.050	905	1.000	Inparanoid score	I355
OMA	1	1.010	-	-		QHG52406
OrthoDB	1	1.010	-	-		D156590at33208
OrthoFinder	1	1.000	-	-		FOG0003053
OrthoInspector	1	1.000	-	-		otm44990
orthoMCL	1	0.900	-	-		OOG6_101440
Panther	1	1.100	-	-	LDO	PTHR23078
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2410
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910