DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and Fign

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_068362.1	Gene:	Fign / 60344	MGIID:	1890647	Length:	759	Species:	Mus musculus

Alignment Length:	333	Identity:	89/333 - (26%)
Similarity:	144/333 - (43%)	Gaps:	63/333 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 EKAENSSLNLQGKSKGKVVRQSIINP--DWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQL 248
            |:.:|:..:|......:::.|   .|  ||.    .|.|||     :.:......|..|.|....
Mouse   459 EQLKNTDTHLIDLVTNEIITQ---GPPVDWS----DIAGLD-----LVKAVIKEEVLWPVLRSDA 511

  Fly   249 --GCKHV-KGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAE 310
              |...: :.|||:||.||||||:.|.|.:.|.|...||. |..::.|::||:|..:...|..|.
Mouse   512 FSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIA-GSGLVAKWIGEAEKIIHASFLVAR 575

  Fly   311 EEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVV---NQLLTKIDGV-----DQLNNI 367
            ..:    |:    :|...:||.:...:.|..     |..|.   .:.|.::|.|     ||   |
Mouse   576 CRQ----PS----VIFVSDIDMLLSSQVSEE-----HSPVSRMRTEFLMQLDTVLTSAEDQ---I 624

  Fly   368 LVIGMTNRRDMIDEALLR--PGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIA 430
            :||..|::.:.|||:|.|  ..||.:.:..|....|..||:|..|          |..:::||.|
Mouse   625 VVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIVQLLTQH----------NYCLNDKEFA 679

  Fly   431 AL---TKNFSGAELEGLVRAAQSSAMNRLIKADAKVTVDPEAMEKLKVNRDDFLHSLEHDIKPAF 492
            .|   |:.|||.::..|.:.|....::.:...|.. .:.|..:.  .|...||.::. ..|:|:.
Mouse   680 LLVQRTEGFSGLDVAHLCQEAAVGPLHAMPATDLS-AIMPSQLR--PVTYQDFENAF-CKIQPSI 740

  Fly   493 GTAQEILD 500
              :|:.||
Mouse   741 --SQKELD 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011
		SpoVK	242..699	CDD:223540	77/275 (28%)
		AAA	256..397	CDD:278434	47/150 (31%)
		AAA	539..668	CDD:278434
Fign	NP_068362.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..237
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..293
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..429
		26Sp45	389..736	CDD:130309	84/319 (26%)
		AAA	522..652	CDD:278434	47/146 (32%)
		Vps4_C	<723..756	CDD:286426	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900