DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and Spata5

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001156983.1	Gene:	Spata5 / 57815	MGIID:	1927170	Length:	893	Species:	Mus musculus

Alignment Length:	706	Identity:	193/706 - (27%)
Similarity:	311/706 - (44%)	Gaps:	152/706 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 VSQEPYDSDQMAKEFIMQFAGMALTVGQSLVFN---FKDKKLLGLAVKSLEAIDPKSLGEGKDTA 168
            |:|.|.|...:..|   :..|:..:...|...|   ..::|||          .|.|.|...:|.
Mouse   270 VTQSPRDGSGLGLE---ESTGLKCSFDSSKEGNTQPVSEEKLL----------KPASAGTKSNTD 321

  Fly   169 MRNVRFGRILGNTVVQFEK-AENSSLNLQGKSKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFR 232
                .|..|...|.:...| ..||.   :..|:.||.        :|.    ||||:.:..:| |
Mouse   322 ----TFYFISSTTRINLRKICTNSK---EQDSQFKVT--------YDM----IGGLNSQLKAI-R 366

  Fly   233 RAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGE 297
            ......:..|||.:..|....:|:|||||||||||::||.:...:.| ...::|||:|:.|:.||
Mouse   367 EIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGA-YVSVINGPEIISKFYGE 430

  Fly   298 SEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVD 362
            :||.:|::||||....    |:    ||..||:||:|.:|  ....|.|...||..|||.:||:.
Mouse   431 TEARLRQIFAEATLRH----PS----IIFIDELDALCPKR--EGAQSEVEKRVVASLLTLMDGIG 485

  Fly   363 QLNN---ILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDV 424
            ...:   :||:|.|||...:|.||.||||.:.::||.:||.|.|:.||....:|:...      :
Mouse   486 SEGSEGRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPHL------L 544

  Fly   425 DNKEIAALTKN---FSGAELEGLVRAAQSSAMNRLIKADAKVTVDPEAMEKLKVNRDDFLHSLEH 486
            ...|:..|..|   :.||:|:.|...|...|:.|:::....:. |.:....:|:..:|||..: :
Mouse   545 TKAELLRLANNAHGYVGADLKALCNEAGLHALRRVLRKQPNLP-DSKVAGMVKITLNDFLQGM-N 607

  Fly   487 DIKPAFGTAQEI---LDNMLARGVINWGAPVSNL--LEDGMLYVQQA-----KAPESSGLV---- 537
            ||:|:  ..:|:   :.|      ::|    |::  ||:..|.::||     |.|:|...:
Mouse   608 DIRPS--AMREVAIDVPN------VSW----SDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQP 660

  Fly   538 --SVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDM---VGYTESAKCLHIRKIFDDAYRSML 597
              .||:.|.|...||.:|..||..|...|:.:..||.|   ||.:|.|    :|:||..|.....
Mouse   661 PKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERA----VREIFRKARAVAP 721

  Fly   598 SCIVVDNVERL-LDYGSIGPRYSNMTLQALLVLLKKQP--PKGRKLLILCTSSRREVLEEMEMLT 659
            |.|..|.::.| ::.|| .....|:..:.|..||.:..  .:.:.:.:|..::|.:.:::..|..
Mouse   722 SIIFFDELDALAVERGS-SSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRP 785

  Fly   660 A-FTSVLHVPNLSKPD------------HVLAV---------LENTDIFSKGEIQAIGKKMAGKR 702
            . ...:::||   .||            |.:.:         :..||.:|..||.|:.|:.|
Mouse   786 GRIDRIIYVP---LPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAEIIAVCKEAA--- 844

  Fly   703 VFIGIKKLLGLID-------MARQTEQSQRAI---------KFLSKMEEEGGLDMV 742
                   ||.|.:       |.|...|:...:         :|....:|:.||..|
Mouse   845 -------LLALEENIKADCIMKRHFTQALSIVTPRIPESLRRFYEDYQEKSGLHTV 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	9/49 (18%)
		SpoVK	242..699	CDD:223540	150/506 (30%)
		AAA	256..397	CDD:278434	61/143 (43%)
		AAA	539..668	CDD:278434	35/135 (26%)
Spata5	NP_001156983.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		CDC48_N	64..132	CDD:304500
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..227
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..315		13/57 (23%)
		SpoVK	370..882	CDD:223540	158/560 (28%)
		AAA	390..522	CDD:278434	60/142 (42%)
		AAA	664..796	CDD:278434	37/139 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810