DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and fignl1

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001122223.1	Gene:	fignl1 / 569539	ZFINID:	ZDB-GENE-030131-1862	Length:	661	Species:	Danio rerio

Alignment Length:	356	Identity:	97/356 - (27%)
Similarity:	149/356 - (41%)	Gaps:	80/356 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 DKKLLGLAVKSLEAIDPKSLGEGKDTAMRNVRFGRILGNTVVQFEKAENSSLNLQGKSKGKVVRQ 206
            |::|.....|.:|.|..:.:..|...|..::        ..::|.||          :..::|..
Zfish   360 DERLKNFEPKIIELIMSEIMDHGPPVAWDDI--------AGLEFAKA----------TIKEIVVW 406

  Fly   207 SIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMAR 271
            .::.||...|..|                     ||           |||||:|||||||||:.:
Zfish   407 PMLRPDIFTGLRG---------------------PP-----------KGILLFGPPGTGKTLIGK 439

  Fly   272 QIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQ 336
            .|.....|....| :...:..|:|||.|..||.|||.|...:..        :|..||||::..|
Zfish   440 CIACQSGATFFSI-SASSLTSKWVGEGEKMVRALFAIARCHQPA--------VIFIDEIDSLLSQ 495

  Fly   337 RGSVAGNSGVHDT---VVNQLLTKIDG--VDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEIS 396
            |     ..|.||:   :..:.|.::||  ....:.|||:|.|||...||||..|  ||..::.|.
Zfish   496 R-----TDGEHDSSRRIKTEFLVQLDGAATSAEDRILVVGATNRPQEIDEAARR--RLAKRLYIP 553

  Fly   397 LPNEQGRVQILNIHTKRMREFNKINDDVDNKE-IAALTKNFSGAELEGLVRAAQSSAMNRLIKAD 460
            ||..:.|.||:.    .:....|....||..| :...|:.||||::..|.|.|....:..:..:|
Zfish   554 LPEAEARRQIVT----NLMSHEKSQLGVDEMEKVVQGTEGFSGADMTQLCREAALGPIRSISLSD 614

  Fly   461 AKVTVDPEAMEKLKVNRDDFLHSLEHDIKPA 491
            . .|:..|.:..:..:  ||..:|: .::|:
Zfish   615 I-ATIMAEQVRPILYS--DFQEALK-TVRPS 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	5/15 (33%)
		SpoVK	242..699	CDD:223540	81/256 (32%)
		AAA	256..397	CDD:278434	54/145 (37%)
		AAA	539..668	CDD:278434
fignl1	NP_001122223.1	AAA	420..556	CDD:214640	59/162 (36%)
		AAA	424..554	CDD:278434	54/145 (37%)
		Vps4_C	<610..658	CDD:286426	7/36 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900