DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and zgc:136908

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001035017.1	Gene:	zgc:136908 / 563679	ZFINID:	ZDB-GENE-060312-22	Length:	805	Species:	Danio rerio

Alignment Length:	615	Identity:	174/615 - (28%)
Similarity:	283/615 - (46%)	Gaps:	97/615 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LEAIDPKSLGE-----GKDTAMRNVRFGRILGNTVVQFEKAENSSLNLQGKSKGKVVRQSIINPD 212
            |||..|...|:     |   .||.|.|..:..:.......|.::.::.:|:...:...:..:|
Zfish   142 LEAYRPVHKGDIFLVRG---GMRAVEFKVVETDPTPHCIVAPDTIIHCEGEPIKREDEEESLN-- 201

  Fly   213 WDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTML 277
             |.|...|||..|:...| :......:..|.|.:.:|.|..:||||||||||||||:||.:
Zfish   202 -DIGYDDIGGCRKQLAQI-KEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLVARAV---- 260

  Fly   278 NAREPK----IVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRG 338
             |.|..    ::|||:|:.|..||||:|:|:.|.|||:....        ||..||:|||..:|.
Zfish   261 -ANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKRE 316

  Fly   339 SVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGR 403
            ...|.  |...:|:||||.:||:.|..:::|:..|||.:.:|.||.|.||.:.:::|.:|:..||
Zfish   317 KTHGE--VERRIVSQLLTLMDGLKQRAHVVVMAATNRPNSVDAALRRFGRFDREIDIGIPDSTGR 379

  Fly   404 VQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNR---LIKADAKVTV 465
            ::||.||||.|    |:::|||.::|:|.|....||:|..|...|...|:.:   ||..:.. ::
Zfish   380 LEILQIHTKNM----KLSEDVDLEQISAETHGHVGADLAALCSEAALQAIRKKMTLIDLEDD-SI 439

  Fly   466 DPEAMEKLKVNRDDFLHSLEHDIKPAFGTAQEILDNMLARGVINW---GA--PVSNLLEDGMLYV 525
            |.:.:..|.|..|||..:|......|      :.:.::....:||   |.  .|...|::.:.|
Zfish   440 DADLLNSLAVTMDDFKWALSQSNPSA------LRETVVEVPHVNWEDIGGLDEVKRELQELVQY- 497

  Fly   526 QQAKAPE---SSGLV---SVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDMV---GYTESAK 581
             ..:.|:   ..|:.   .||..|.|..|||.||..:|......||.:..||.:.   |.:|:
Zfish   498 -PVEYPDKFLKFGMTPSRGVLFYGPPGCGKTLLAKAIANECQANFVSIKGPELLTMWFGESEA-- 559

  Fly   582 CLHIRKIFDDAYRSMLSCIV----VDNVERLL-----DYGSIGPRYSNMTLQALLVLLKKQPPKG 637
              ::|.:||.| |....||:    :|::.:..     |.|....|..|..|..:..:..|
Zfish   560 --NVRDVFDKA-RQAAPCILFFDELDSIAKARGGGAGDAGGAADRVINQILTEMDGMTNK----- 616

  Fly   638 RKLLILCTSSRREVLEEMEMLTA-FTSVLHVPNLSKPDH---VLAVLENTDIFSKGEIQAIGKKM 698
            :.:.|:..::|.::::...:... ...::::|....|..   :.|.|..:.:....::..:.|..
Zfish   617 KNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDMPSRTAILRANLRKSPVAKDVDLMYLSKIT 681

  Fly   699 AGKRVFIGIKKLLGLIDMARQTEQSQRAIK 728
            .|   |.|          |..||..|||.|
Zfish   682 EG---FSG----------ADLTEICQRACK 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	3/4 (75%)
		SpoVK	242..699	CDD:223540	144/490 (29%)
		AAA	256..397	CDD:278434	61/144 (42%)
		AAA	539..668	CDD:278434	32/141 (23%)
zgc:136908	NP_001035017.1	CDC48	27..766	CDD:273521	174/615 (28%)
		CDC48_N	27..109	CDD:280513
		CDC48_2	133..193	CDD:215011	12/53 (23%)
		AAA	243..372	CDD:278434	60/143 (42%)
		AAA	516..649	CDD:278434	32/142 (23%)
		Vps4_C	<731..762	CDD:286426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810