DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and fignl2

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001201837.1	Gene:	fignl2 / 561837	ZFINID:	ZDB-GENE-090313-189	Length:	684	Species:	Danio rerio

Alignment Length:	458	Identity:	90/458 - (19%)
Similarity:	164/458 - (35%)	Gaps:	147/458 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LQKK----TVSQEPYDSDQMAKEFIMQFAGMALTVGQSLVFNFKDKKLLGLAVKSLEAIDPKSLG 162
            |::|    |:.:|..||.:..|     ::...:..|....:...||...|....|   .||:...
Zfish   283 LKRKAFEMTLDEEDSDSSRYRK-----YSYDPMKTGGDSPYGVTDKAGNGFGTGS---TDPQGFK 339

  Fly   163 EGKDTAMRNVRFGRILGNTVVQFEKAENSSLNLQGKSKGKVV-RQSIINPDWDFGKMG------- 219
            ..|                       .:|..:|:|...||.. .:.:::|  .:|..|
Zfish   340 PSK-----------------------PSSQSSLEGDEVGKYSGLKPLVSP--TYGAAGDYSPPAA 379

  Fly   220 ----IGGLDKEF--NSIFRRAFASRVFPPELVEQL-----------------GCKHVKG------ 255
                .||.::.|  |...:|:...:...|.::|.:                 |..|:|.
Zfish   380 MTGENGGAEQGFSQNRSQKRSDPMKSIEPRMLELVSRELQDCSPAMLWTELAGNCHIKAALEEDL 444

  Fly   256 ----------------ILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANVRR 304
                            |||:||.|.|||.:||.:.:.:.|...:: :...:..|..||:|..:..
Zfish   445 LWPVLRPNPAIHPPKTILLFGPQGGGKTTLARSLSSQIGASFYRL-SCATLASKLKGEAEQLLLT 508

  Fly   305 LFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGV--DQLNNI 367
            ||:.|...:..:        ::..|::|| ::.|           :..||..:::.:  :|.|..
Zfish   509 LFSVATARQPAM--------VLLSEVEAI-EEEG-----------LRQQLQAQLEKIQHNQSNQF 553

  Fly   368 LVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIAAL 432
            ||:..|.|.|:|.::|||  ....:..|.||:...|..:|      ::........:..:|::|:
Zfish   554 LVVCTTRRPDLIKDSLLR--CFSKRYHIGLPDGNTRRHVL------LQALAPQGCSLSERELSAV 610

  Fly   433 TKNFSGAELEGLVRAAQSSAMNRLIKADAKVTVDPEAMEKLKVNRDDFLHSLE--------HDIK 489
            .:...|..:..|::..|.:    |..|.|..:|.              ||||.        .|.:
Zfish   611 LQRSEGFSVWELLQLCQQA----LASASASASVP--------------LHSLPASLSSPTLQDFE 657

  Fly   490 PAF 492
            .||
Zfish   658 NAF 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	8/46 (17%)
		SpoVK	242..699	CDD:223540	62/300 (21%)
		AAA	256..397	CDD:278434	37/142 (26%)
		AAA	539..668	CDD:278434
fignl2	NP_001201837.1	AAA	457..583	CDD:214640	38/148 (26%)
fignl2	NP_001201837.1	AAA	461..581	CDD:278434	37/142 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900