Protein Alignment comt and zgc:153738

DIOPT Version :10

• Sequence 1: NP_524877.1
• Gene: comt / 47091
• FlyBaseID: FBgn0000346
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_001073437.3
• Gene: zgc:153738 / 558115
• ZFINID: ZDB-GENE-061013-622
• Length: 818
• Species: Danio rerio
• Alignment Length: 741
• Identity: 143/741 - (19%)
• Similarity: 252/741 - (34%)
• Gaps: 238/741 - (32%)

  Fly    21 AIVNVGDFPEEIKYADISPAPGQHFIFALEKTVEVPSGYVGFSLVQ----------RKWAMVSIN 75
            ||:|..|..|:       ..|....:..||:|::|         :|          |...|..|:
Zfish   141 AILNQMDVMEK-------SGPPVMRMLTLERTIKV---------IQVAERARQGRLRAKFMREIH 189

  Fly    76 QELEVRPYRFD----ASSDVITCV-SFETDFLQKKTVSQEPYDSDQMAKEFIMQFAGMALTVGQS 135
            ::.| |..|.|    :|.....|: .....|:|:|...:        .:|..|.|.||||
Zfish   190 RDSE-RQKRADIETVSSDQAAVCIQKVWRGFMQRKITKR--------LREEEMIFLGMAL----- 240

  Fly   136 LVFNFKDKKLLGLAVKSLEAIDPKSLGEGKDTAMRNVR-------FGRILGNTVVQFEKAENSSL 193
                  |.||...:...|.|.:.|        |:|..|       :.:.:|:.|.|..:.|.|.:
Zfish   241 ------DPKLSYPSQTELIAQNNK--------ALRRTRQEEHEDDYQKSIGSVVHQLREVEGSEM 291

  Fly   194 NLQGKSKGKVVRQSIIN--------PDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGC 250
            ....|.:   :||..|.        ||:...:.|...|          .||.:. |.||.|:|..
Zfish   292 KETMKDQ---IRQWFIECRDATGSFPDYPEEEDGGSAL----------IFAEKT-PEELAEELAA 342

  Fly   251 KHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKR 315
            |..:..                      .:.||            |:.:...:....:.|:||:.
Zfish   343 KEEEDA----------------------NKNPK------------GKEDTKEKAKKGKIEDEEEE 373

  Fly   316 LG----PNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRR 376
            .|    |::.|     .:::...|....|..|.                 ::..|     .:.|.
Zfish   374 PGLKMLPSACL-----PDLERSHKTYSEVWKNR-----------------NESKN-----FSQRH 411

  Fly   377 DMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIA----ALTKNFS 437
            ::  |.:....|.|:::||       |.|:               |::..:|:|    |:.|..|
Zfish   412 EL--ELIKEDKRKEIEVEI-------RKQV---------------DELMRQELANWKLAVDKEKS 452

  Fly   438 GAELEGLVRAAQSSAMNRLIKADAKVTVD--PEAM-------EKLK----VNRDDFLHSLEHDIK 489
            | :::|..:..::|...:..|.|..:|.|  .|::       |.||    |...|:|....:
Zfish   453 G-KVKGAAKKKKASKSAKRKKKDKDLTADRTTESLFEELVEQELLKKPENVKLKDYLGDYSY--- 513

  Fly   490 PAFGTAQEILDNMLARGVINWGAPVSNLLEDGMLYV-----QQAKAPESSGLVSVLVAGAPNSGK 549
                     |...|.:..|.....:|::.:...||.     .||...:|..:.::|:.|....||
Zfish   514 ---------LGTTLRQSDIEPMPSLSDVRQVVALYAILPLGSQAVHEKSPLVKTILLVGPSGVGK 569

  Fly   550 TALAAQL-----AKMSDFPFVKVCSPEDMVGYTESAKCLHIRKIFDDAYRSMLSCIVVDNVERLL 609
            ..|...:     |.:.|...:.|.  :...|.......||:  :|..|.....|.|.:.:.|::.
Zfish   570 KMLVHAICQETGANLFDLSPLNVA--KKYPGRNGLQMMLHL--VFKVARLMQPSVIWIGDAEKMF 630

  Fly   610 DYGSIGPRYSNMTLQALLVLLKKQPPKGRK-------LLILCTSSRREVLEEMEMLTAFTSVLHV 667
             |..:......:..:.    |||..||..|       :||:.|:|.....:...:...:..::.:
Zfish   631 -YRKVPKEEKELDPKR----LKKDLPKILKSIRGEDCVLIVGTTSDPHSADLKSLCKFYNKIILI 690

  Fly   668 PNLSKPDHVLAVLENTDIFSK--GEI 691
            |   :||:....:...::..|  ||:
Zfish   691 P---RPDYASRYVMWKELIKKNGGEV 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_524877.1	CDC48_N	5..83	CDD:215012	16/71 (23%)
		CDC48_2	111..>158	CDD:215011	12/46 (26%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	27/179 (15%)
		CDC48	<220..>606	CDD:273521	74/416 (18%)
		SpoVK	<526..702	CDD:440232	36/180 (20%)
zgc:153738	NP_001073437.3	IQ	207..223	CDD:197470	3/15 (20%)
		RecA-like_IQCA1	531..690	CDD:410914	32/167 (19%)